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Items: 1 to 20 of 69

1.

Direct-reversible binding of small molecules to G protein βγ subunits.

Seneviratne AM, Burroughs M, Giralt E, Smrcka AV.

Biochim Biophys Acta. 2011 Sep;1814(9):1210-8. doi: 10.1016/j.bbapap.2011.05.010. Epub 2011 May 18.

2.

Conformational flexibility and binding interactions of the G protein βγ heterodimer.

Park MS, Smrcka AV, Stern HA.

Proteins. 2011 Feb;79(2):518-27. doi: 10.1002/prot.22899.

3.

Functional selectivity and biased receptor signaling.

Kenakin T.

J Pharmacol Exp Ther. 2011 Feb;336(2):296-302. doi: 10.1124/jpet.110.173948. Epub 2010 Oct 28.

4.

Rational design of a selective covalent modifier of G protein βγ subunits.

Dessal AL, Prades R, Giralt E, Smrcka AV.

Mol Pharmacol. 2011 Jan;79(1):24-33. doi: 10.1124/mol.110.068155. Epub 2010 Sep 29.

5.

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.

Casey LM, Pistner AR, Belmonte SL, Migdalovich D, Stolpnik O, Nwakanma FE, Vorobiof G, Dunaevsky O, Matavel A, Lopes CM, Smrcka AV, Blaxall BC.

Circ Res. 2010 Aug 20;107(4):532-9. doi: 10.1161/CIRCRESAHA.110.217075. Epub 2010 Jun 24.

6.

Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J.

J Med Chem. 2010 Feb 25;53(4):1867-70. doi: 10.1021/jm9017515.

7.

Gbetagamma signaling promotes breast cancer cell migration and invasion.

Kirui JK, Xie Y, Wolff DW, Jiang H, Abel PW, Tu Y.

J Pharmacol Exp Ther. 2010 May;333(2):393-403. doi: 10.1124/jpet.109.164814. Epub 2010 Jan 28.

8.

G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.

Ahmed SM, Daulat AM, Meunier A, Angers S.

J Biol Chem. 2010 Feb 26;285(9):6538-51. doi: 10.1074/jbc.M109.069948. Epub 2010 Jan 4.

9.

NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.

Smrcka AV, Kichik N, Tarragó T, Burroughs M, Park MS, Itoga NK, Stern HA, Willardson BM, Giralt E.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):639-44. doi: 10.1073/pnas.0909503107. Epub 2009 Dec 16.

10.

Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.

Bianchi E, Norcini M, Smrcka A, Ghelardini C.

J Neurochem. 2009 Oct;111(1):171-80. doi: 10.1111/j.1471-4159.2009.06308.x. Epub 2009 Jul 27.

11.

The structure and function of G-protein-coupled receptors.

Rosenbaum DM, Rasmussen SG, Kobilka BK.

Nature. 2009 May 21;459(7245):356-63. doi: 10.1038/nature08144. Review.

12.

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.

Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin MF, Tu Y.

Oncogene. 2009 Apr 23;28(16):1853-63. doi: 10.1038/onc.2009.30. Epub 2009 Mar 23.

13.
14.

The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.

Dupré DJ, Robitaille M, Rebois RV, Hébert TE.

Annu Rev Pharmacol Toxicol. 2009;49:31-56. doi: 10.1146/annurev-pharmtox-061008-103038. Review.

15.

G protein betagamma subunits as targets for small molecule therapeutic development.

Smrcka AV, Lehmann DM, Dessal AL.

Comb Chem High Throughput Screen. 2008 Jun;11(5):382-95. Review.

16.

G protein βγ subunits: central mediators of G protein-coupled receptor signaling.

Smrcka AV.

Cell Mol Life Sci. 2008 Jul;65(14):2191-214. doi: 10.1007/s00018-008-8006-5. Review.

17.

Structural diversity of G protein-coupled receptors and significance for drug discovery.

Lagerström MC, Schiöth HB.

Nat Rev Drug Discov. 2008 Apr;7(4):339-57. doi: 10.1038/nrd2518. Review. Erratum in: Nat Rev Drug Discov. 2008 Jun;7(6):542.

PMID:
18382464
18.

Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.

Ueda H, Nagae R, Kozawa M, Morishita R, Kimura S, Nagase T, Ohara O, Yoshida S, Asano T.

J Biol Chem. 2008 Jan 25;283(4):1946-53. Epub 2007 Nov 28.

19.

Heterotrimeric G protein activation by G-protein-coupled receptors.

Oldham WM, Hamm HE.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):60-71. Review.

PMID:
18043707
20.

Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation.

Lehmann DM, Seneviratne AM, Smrcka AV.

Mol Pharmacol. 2008 Feb;73(2):410-8. Epub 2007 Nov 15.

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