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Items: 1 to 20 of 59

1.

Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.

Science. 2010 Apr 16;328(5976):372-6. doi: 10.1126/science.1186068. Epub 2010 Mar 25. Erratum in: Science. 2010 May 21;328(5981):974.

2.

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM.

J Immunol. 2010 Apr 1;184(7):3433-41. doi: 10.4049/jimmunol.0904028. Epub 2010 Feb 24.

3.

Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

Long M, Park SG, Strickland I, Hayden MS, Ghosh S.

Immunity. 2009 Dec 18;31(6):921-31. doi: 10.1016/j.immuni.2009.09.022.

4.

PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.

Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA.

J Clin Invest. 2009 Dec;119(12):3774-86. doi: 10.1172/JCI39692. Epub 2009 Nov 9.

5.

Mechanisms of foxp3+ T regulatory cell-mediated suppression.

Shevach EM.

Immunity. 2009 May;30(5):636-45. doi: 10.1016/j.immuni.2009.04.010. Review.

6.

PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.

Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G.

Mol Immunol. 2009 Jun;46(10):2071-9. doi: 10.1016/j.molimm.2009.02.030. Epub 2009 Apr 7.

PMID:
19356803
7.

CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.

Blonska M, Lin X.

Immunol Rev. 2009 Mar;228(1):199-211. doi: 10.1111/j.1600-065X.2008.00749.x. Review.

8.

Structural basis of protein kinase C isoform function.

Steinberg SF.

Physiol Rev. 2008 Oct;88(4):1341-78. doi: 10.1152/physrev.00034.2007. Review.

9.

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.

Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T.

Immunity. 2008 Oct 17;29(4):589-601. doi: 10.1016/j.immuni.2008.08.011. Epub 2008 Oct 9.

10.

CTLA-4 control over Foxp3+ regulatory T cell function.

Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S.

Science. 2008 Oct 10;322(5899):271-5. doi: 10.1126/science.1160062.

11.

Differential requirement of PKC-theta in the development and function of natural regulatory T cells.

Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z.

Mol Immunol. 2008 Dec;46(2):213-24. doi: 10.1016/j.molimm.2008.08.275. Epub 2008 Oct 8.

12.

Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.

Beal AM, Anikeeva N, Varma R, Cameron TO, Norris PJ, Dustin ML, Sykulev Y.

J Immunol. 2008 Oct 1;181(7):4815-24.

13.

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.

Skvara H, Dawid M, Kleyn E, Wolff B, Meingassner JG, Knight H, Dumortier T, Kopp T, Fallahi N, Stary G, Burkhart C, Grenet O, Wagner J, Hijazi Y, Morris RE, McGeown C, Rordorf C, Griffiths CE, Stingl G, Jung T.

J Clin Invest. 2008 Sep;118(9):3151-9. doi: 10.1172/JCI35636.

14.

A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection.

Manicassamy S, Yin D, Zhang Z, Molinero LL, Alegre ML, Sun Z.

J Immunol. 2008 Jul 1;181(1):513-20.

15.

Regulatory T cells and immune tolerance.

Sakaguchi S, Yamaguchi T, Nomura T, Ono M.

Cell. 2008 May 30;133(5):775-87. doi: 10.1016/j.cell.2008.05.009. Review.

16.

A blocking anti-CD28-specific antibody induces long-term heart allograft survival by suppression of the PKC theta-JNK signal pathway.

Jang MS, Pan F, Erickson LM, Fisniku O, Crews G, Wynn C, Hong IC, Tamura K, Kobayashi M, Jiang H.

Transplantation. 2008 Apr 15;85(7):1051-5. doi: 10.1097/TP.0b013e31816846f6.

PMID:
18408588
17.

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells.

Ding Y, Shen S, Lino AC, Curotto de Lafaille MA, Lafaille JJ.

Nat Med. 2008 Feb;14(2):162-9. doi: 10.1038/nm1707. Epub 2008 Feb 3.

PMID:
18246080
18.

Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells.

Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale RD.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20296-301. Epub 2007 Dec 12.

19.

Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility.

Yam PT, Wilson CA, Ji L, Hebert B, Barnhart EL, Dye NA, Wiseman PW, Danuser G, Theriot JA.

J Cell Biol. 2007 Sep 24;178(7):1207-21.

20.

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

Sims TN, Soos TJ, Xenias HS, Dubin-Thaler B, Hofman JM, Waite JC, Cameron TO, Thomas VK, Varma R, Wiggins CH, Sheetz MP, Littman DR, Dustin ML.

Cell. 2007 May 18;129(4):773-85.

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