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Items: 1 to 20 of 63


The alternating-access mechanism of MFS transporters arises from inverted-topology repeats.

Radestock S, Forrest LR.

J Mol Biol. 2011 Apr 15;407(5):698-715. doi: 10.1016/j.jmb.2011.02.008. Epub 2011 Feb 18.


Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport.

Jiang X, Nie Y, Kaback HR.

Biochemistry. 2011 Mar 15;50(10):1634-40. doi: 10.1021/bi101988s. Epub 2011 Feb 8.


The alternating access transport mechanism in LacY.

Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y.

J Membr Biol. 2011 Jan;239(1-2):85-93. doi: 10.1007/s00232-010-9327-5. Epub 2010 Dec 16. Review.


Structure of a fucose transporter in an outward-open conformation.

Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N.

Nature. 2010 Oct 7;467(7316):734-8. doi: 10.1038/nature09406. Epub 2010 Sep 26.


Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane.

Nie Y, Kaback HR.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9903-8. doi: 10.1073/pnas.1004515107. Epub 2010 May 10.


Probing of the rates of alternating access in LacY with Trp fluorescence.

Smirnova I, Kasho V, Sugihara J, Kaback HR.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21561-6. doi: 10.1073/pnas.0911434106. Epub 2009 Dec 3.


Residues gating the periplasmic pathway of LacY.

Zhou Y, Nie Y, Kaback HR.

J Mol Biol. 2009 Nov 27;394(2):219-25. doi: 10.1016/j.jmb.2009.09.043. Epub 2009 Sep 23.


Electrophysiological characterization of LacY.

Garcia-Celma JJ, Smirnova IN, Kaback HR, Fendler K.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7373-8. doi: 10.1073/pnas.0902471106. Epub 2009 Apr 21.


Structural characterization of the osmosensor ProP.

Sayeed WM, Baenziger JE.

Biochim Biophys Acta. 2009 May;1788(5):1108-15. doi: 10.1016/j.bbamem.2009.01.010. Epub 2009 Feb 6.


Clogging the periplasmic pathway in LacY.

Nie Y, Zhou Y, Kaback HR.

Biochemistry. 2009 Feb 3;48(4):738-43. doi: 10.1021/bi801976r.


The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway.

Nie Y, Sabetfard FE, Kaback HR.

J Mol Biol. 2008 Jun 13;379(4):695-703. doi: 10.1016/j.jmb.2008.04.015. Epub 2008 Apr 11.


Opening and closing of the periplasmic gate in lactose permease.

Zhou Y, Guan L, Freites JA, Kaback HR.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3774-8. doi: 10.1073/pnas.0800825105. Epub 2008 Mar 4.


Sugar binding induces an outward facing conformation of LacY.

Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback HR.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16504-9. Epub 2007 Oct 9.


Site-directed alkylation of LacY: effect of the proton electrochemical gradient.

Nie Y, Ermolova N, Kaback HR.

J Mol Biol. 2007 Nov 23;374(2):356-64. Epub 2007 Sep 11.


Structural determination of wild-type lactose permease.

Guan L, Mirza O, Verner G, Iwata S, Kaback HR.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15294-8. Epub 2007 Sep 19.


Single-molecule FRET reveals sugar-induced conformational dynamics in LacY.

Majumdar DS, Smirnova I, Kasho V, Nir E, Kong X, Weiss S, Kaback HR.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12640-5. Epub 2007 May 14.


Site-directed alkylation and the alternating access model for LacY.

Kaback HR, Dunten R, Frillingos S, Venkatesan P, Kwaw I, Zhang W, Ermolova N.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):491-4. Epub 2006 Dec 15.


Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli.

Nie Y, Smirnova I, Kasho V, Kaback HR.

J Biol Chem. 2006 Nov 24;281(47):35779-84. Epub 2006 Sep 26.


Lessons from lactose permease.

Guan L, Kaback HR.

Annu Rev Biophys Biomol Struct. 2006;35:67-91. Review.


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