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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

Guo JU, Su Y, Zhong C, Ming GL, Song H.

Cell. 2011 Apr 29;145(3):423-34. doi: 10.1016/j.cell.2011.03.022. Epub 2011 Apr 14.


Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Cortázar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A, Schär P.

Nature. 2011 Feb 17;470(7334):419-23. doi: 10.1038/nature09672. Epub 2011 Jan 30.


Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.

Globisch D, Münzel M, Müller M, Michalakis S, Wagner M, Koch S, Brückl T, Biel M, Carell T.

PLoS One. 2010 Dec 23;5(12):e15367. doi: 10.1371/journal.pone.0015367.


Active DNA demethylation: many roads lead to Rome.

Wu SC, Zhang Y.

Nat Rev Mol Cell Biol. 2010 Sep;11(9):607-20. doi: 10.1038/nrm2950. Epub 2010 Aug 4. Review. Erratum in: Nat Rev Mol Cell Biol. 2010 Oct;11(10):750.


Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.

Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA.

Science. 2010 Jul 2;329(5987):78-82. doi: 10.1126/science.1187945.


Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

Popp C, Dean W, Feng S, Cokus SJ, Andrews S, Pellegrini M, Jacobsen SE, Reik W.

Nature. 2010 Feb 25;463(7284):1101-5. doi: 10.1038/nature08829.


Reprogramming towards pluripotency requires AID-dependent DNA demethylation.

Bhutani N, Brady JJ, Damian M, Sacco A, Corbel SY, Blau HM.

Nature. 2010 Feb 25;463(7284):1042-7. doi: 10.1038/nature08752.


DNA demethylation in hormone-induced transcriptional derepression.

Kim MS, Kondo T, Takada I, Youn MY, Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I, Kitagawa H, Takeyama K, Shibuya H, Ohtake F, Kato S.

Nature. 2009 Oct 15;461(7266):1007-12. doi: 10.1038/nature08456. Erratum in: Nature. 2011 Dec 1;480(7375):132. Retraction in: Kim MS, Kondo T, Takada I, Youn MY, Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I, Kitagawa H, Takeyama K, Shibuya H, Ohtake F, Kato S. Nature. 2012 Jun 14;486(7402):280.


CpG islands--'a rough guide'.

Illingworth RS, Bird AP.

FEBS Lett. 2009 Jun 5;583(11):1713-20. doi: 10.1016/j.febslet.2009.04.012. Epub 2009 Apr 18. Review.


The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.

Kriaucionis S, Heintz N.

Science. 2009 May 15;324(5929):929-30. doi: 10.1126/science.1169786. Epub 2009 Apr 16.


Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.

Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A.

Science. 2009 May 15;324(5929):930-5. doi: 10.1126/science.1170116. Epub 2009 Apr 16.


Active DNA demethylation and DNA repair.

Niehrs C.

Differentiation. 2009 Jan;77(1):1-11. doi: 10.1016/j.diff.2008.09.004. Epub 2008 Oct 25. Review.


TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.

Schmitz KM, Schmitt N, Hoffmann-Rohrer U, Schäfer A, Grummt I, Mayer C.

Mol Cell. 2009 Feb 13;33(3):344-53. doi: 10.1016/j.molcel.2009.01.015.


DNA demethylation by DNA repair.

Gehring M, Reik W, Henikoff S.

Trends Genet. 2009 Feb;25(2):82-90. doi: 10.1016/j.tig.2008.12.001. Epub 2009 Jan 12. Review.


Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer.

Howard JH, Frolov A, Tzeng CW, Stewart A, Midzak A, Majmundar A, Godwin A, Heslin M, Bellacosa A, Arnoletti JP.

Cancer Biol Ther. 2009 Jan;8(1):94-100. Epub 2009 Jan 20.


Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis.

Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H.

Science. 2009 Feb 20;323(5917):1074-7. doi: 10.1126/science.1166859. Epub 2009 Jan 1.


DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR.

Cell. 2008 Dec 26;135(7):1201-12. doi: 10.1016/j.cell.2008.11.042.


The colorful history of active DNA demethylation.

Ooi SK, Bestor TH.

Cell. 2008 Jun 27;133(7):1145-8. doi: 10.1016/j.cell.2008.06.009. Review.


Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, Stadler MB, Bibel M, Schübeler D.

Mol Cell. 2008 Jun 20;30(6):755-66. doi: 10.1016/j.molcel.2008.05.007. Epub 2008 May 29.


GADD45A does not promote DNA demethylation.

Jin SG, Guo C, Pfeifer GP.

PLoS Genet. 2008 Mar 7;4(3):e1000013. doi: 10.1371/journal.pgen.1000013.

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