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Items: 1 to 20 of 36

1.

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.

Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.

2.

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.

Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K.

Nature. 2011 Mar 31;471(7340):633-6. doi: 10.1038/nature09815.

PMID:
21455180
3.

Linear ubiquitination prevents inflammation and regulates immune signalling.

Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H.

Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.

PMID:
21455173
4.

NF-κB in the regulation of epithelial homeostasis and inflammation.

Wullaert A, Bonnet MC, Pasparakis M.

Cell Res. 2011 Jan;21(1):146-58. doi: 10.1038/cr.2010.175. Epub 2010 Dec 14. Review.

5.

Cytoscape 2.8: new features for data integration and network visualization.

Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T.

Bioinformatics. 2011 Feb 1;27(3):431-2. doi: 10.1093/bioinformatics/btq675. Epub 2010 Dec 12.

6.

Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.

Landgraf K, Bollig F, Trowe MO, Besenbeck B, Ebert C, Kruspe D, Kispert A, Hänel F, Englert C.

Mol Cell Biol. 2010 Dec;30(24):5764-75. doi: 10.1128/MCB.01645-09. Epub 2010 Oct 18.

7.

Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.

Warren SE, Armstrong A, Hamilton MK, Mao DP, Leaf IA, Miao EA, Aderem A.

J Immunol. 2010 Jul 15;185(2):818-21. doi: 10.4049/jimmunol.1000724. Epub 2010 Jun 18.

8.

Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.

He L, Ingram A, Rybak AP, Tang D.

J Clin Invest. 2010 Jun;120(6):2094-108. doi: 10.1172/JCI40778. Epub 2010 May 10.

9.

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.

Kawai T, Akira S.

Nat Immunol. 2010 May;11(5):373-84. doi: 10.1038/ni.1863. Epub 2010 Apr 20. Review.

PMID:
20404851
10.

A key role for ATF3 in regulating mast cell survival and mediator release.

Gilchrist M, Henderson WR Jr, Morotti A, Johnson CD, Nachman A, Schmitz F, Smith KD, Aderem A.

Blood. 2010 Jun 10;115(23):4734-41. doi: 10.1182/blood-2009-03-213512. Epub 2010 Mar 4.

11.

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.

Siggs OM, Berger M, Krebs P, Arnold CN, Eidenschenk C, Huber C, Pirie E, Smart NG, Khovananth K, Xia Y, McInerney G, Karlsson Hedestam GB, Nemazee D, Beutler B.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3046-51. doi: 10.1073/pnas.0915098107. Epub 2010 Jan 28.

12.

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.

Xiao N, Eidenschenk C, Krebs P, Brandl K, Blasius AL, Xia Y, Khovananth K, Smart NG, Beutler B.

J Immunol. 2009 Dec 15;183(12):7975-83. doi: 10.4049/jimmunol.0902718.

13.

The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes.

Savinova OV, Hoffmann A, Ghosh G.

Mol Cell. 2009 Jun 12;34(5):591-602. doi: 10.1016/j.molcel.2009.04.033.

14.

Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals.

Litvak V, Ramsey SA, Rust AG, Zak DE, Kennedy KA, Lampano AE, Nykter M, Shmulevich I, Aderem A.

Nat Immunol. 2009 Apr;10(4):437-43. doi: 10.1038/ni.1721. Epub 2009 Mar 8.

15.

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.

Nat Cell Biol. 2009 Feb;11(2):123-32. doi: 10.1038/ncb1821. Epub 2009 Jan 11.

PMID:
19136968
16.

Systems biology of innate immunity.

Zak DE, Aderem A.

Immunol Rev. 2009 Jan;227(1):264-82. doi: 10.1111/j.1600-065X.2008.00721.x. Review.

17.

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.

Sriskantharajah S, Belich MP, Papoutsopoulou S, Janzen J, Tybulewicz V, Seddon B, Ley SC.

Nat Immunol. 2009 Jan;10(1):38-47. doi: 10.1038/ni.1685. Epub 2008 Dec 7.

PMID:
19060899
18.

InnateDB: facilitating systems-level analyses of the mammalian innate immune response.

Lynn DJ, Winsor GL, Chan C, Richard N, Laird MR, Barsky A, Gardy JL, Roche FM, Chan TH, Shah N, Lo R, Naseer M, Que J, Yau M, Acab M, Tulpan D, Whiteside MD, Chikatamarla A, Mah B, Munzner T, Hokamp K, Hancock RE, Brinkman FS.

Mol Syst Biol. 2008;4:218. doi: 10.1038/msb.2008.55. Epub 2008 Sep 2.

19.

Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.

Ramsey SA, Klemm SL, Zak DE, Kennedy KA, Thorsson V, Li B, Gilchrist M, Gold ES, Johnson CD, Litvak V, Navarro G, Roach JC, Rosenberger CM, Rust AG, Yudkovsky N, Aderem A, Shmulevich I.

PLoS Comput Biol. 2008 Mar 21;4(3):e1000021. doi: 10.1371/journal.pcbi.1000021. Erratum in: PLoS Comput Biol. 2008 Mar;4(3). doi: 10.1371/annotation/e14ad837-e5ff-4bd5-a5f2-f32e784d75a2. PLoS Comput Biol. 2008 Mar;4(3). doi: 10.1371/annotation/1c55be5f-ecd7-49be-91c1-91881be60297.

20.

Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.

Leber JH, Crimmins GT, Raghavan S, Meyer-Morse NP, Cox JS, Portnoy DA.

PLoS Pathog. 2008 Jan;4(1):e6. doi: 10.1371/journal.ppat.0040006.

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