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Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein.

Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):498-509. doi: 10.1165/rcmb.2010-0347OC. Epub 2010 Dec 17.


TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer.

Yao Z, Fenoglio S, Gao DC, Camiolo M, Stiles B, Lindsted T, Schlederer M, Johns C, Altorki N, Mittal V, Kenner L, Sordella R.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15535-40. doi: 10.1073/pnas.1009472107. Epub 2010 Aug 16.


Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK.

J Biol Chem. 2010 Jul 16;285(29):22103-13. doi: 10.1074/jbc.M110.121467. Epub 2010 May 13.


Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells.

Maguire JA, Mulugeta S, Beers MF.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):404-14. doi: 10.1165/rcmb.2009-0382OC. Epub 2010 May 12.


Inhibition and role of let-7d in idiopathic pulmonary fibrosis.

Pandit KV, Corcoran D, Yousef H, Yarlagadda M, Tzouvelekis A, Gibson KF, Konishi K, Yousem SA, Singh M, Handley D, Richards T, Selman M, Watkins SC, Pardo A, Ben-Yehudah A, Bouros D, Eickelberg O, Ray P, Benos PV, Kaminski N.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):220-9. doi: 10.1164/rccm.200911-1698OC. Epub 2010 Apr 15.


Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.

Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Yokoyama A, Kohno N.

Thorax. 2010 Apr;65(4):334-40. doi: 10.1136/thx.2009.119974.


TGF-beta signaling and the role of inhibitory Smads in non-small cell lung cancer.

Jeon HS, Jen J.

J Thorac Oncol. 2010 Apr;5(4):417-9. doi: 10.1097/JTO.0b013e3181ce3afd. Review.


Tgf-beta signaling pathway in lung adenocarcinoma invasion.

Toonkel RL, Borczuk AC, Powell CA.

J Thorac Oncol. 2010 Feb;5(2):153-7. doi: 10.1097/JTO.0b013e3181c8cc0c. Review.


Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.

Latella G, Vetuschi A, Sferra R, Catitti V, D'Angelo A, Zanninelli G, Flanders KC, Gaudio E.

Liver Int. 2009 Aug;29(7):997-1009. doi: 10.1111/j.1478-3231.2009.02011.x. Epub 2009 Apr 28.


Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis.

Konishi K, Gibson KF, Lindell KO, Richards TJ, Zhang Y, Dhir R, Bisceglia M, Gilbert S, Yousem SA, Song JW, Kim DS, Kaminski N.

Am J Respir Crit Care Med. 2009 Jul 15;180(2):167-75. doi: 10.1164/rccm.200810-1596OC. Epub 2009 Apr 10. Erratum in: Am J Respir Crit Care Med. 2009 Aug 15;180(4):380.


Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis.

Latella G, Vetuschi A, Sferra R, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Flanders KC, Gaudio E.

Eur J Clin Invest. 2009 Feb;39(2):145-56. doi: 10.1111/j.1365-2362.2008.02076.x.


Structure and function of a transcriptional network activated by the MAPK Hog1.

Capaldi AP, Kaplan T, Liu Y, Habib N, Regev A, Friedman N, O'Shea EK.

Nat Genet. 2008 Nov;40(11):1300-6. doi: 10.1038/ng.235. Epub 2008 Oct 19.


UniPROBE: an online database of protein binding microarray data on protein-DNA interactions.

Newburger DE, Bulyk ML.

Nucleic Acids Res. 2009 Jan;37(Database issue):D77-82. doi: 10.1093/nar/gkn660. Epub 2008 Oct 8.


MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.

Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N.

PLoS Med. 2008 Apr 29;5(4):e93. doi: 10.1371/journal.pmed.0050093.


Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis.

Yu H, Königshoff M, Jayachandran A, Handley D, Seeger W, Kaminski N, Eickelberg O.

FASEB J. 2008 Jun;22(6):1778-89. doi: 10.1096/fj.07-083857. Epub 2008 Feb 1.


Cellular and molecular mechanisms of fibrosis.

Wynn TA.

J Pathol. 2008 Jan;214(2):199-210. Review.


TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs.

Alejandre-Alcázar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG, Tibboel D, Seeger W, Eickelberg O, Morty RE.

Dev Dyn. 2008 Jan;237(1):259-69.


SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains.

Minoo P, Hu L, Zhu N, Borok Z, Bellusci S, Groffen J, Kardassis D, Li C.

Nucleic Acids Res. 2008 Jan;36(1):179-88. Epub 2007 Nov 14.


Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells.

Kim JH, Jang YS, Eom KS, Hwang YI, Kang HR, Jang SH, Kim CH, Park YB, Lee MG, Hyun IG, Jung KS, Kim DG.

J Korean Med Sci. 2007 Oct;22(5):898-904.


Differentiation plasticity regulated by TGF-beta family proteins in development and disease.

Derynck R, Akhurst RJ.

Nat Cell Biol. 2007 Sep;9(9):1000-4.


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