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Items: 1 to 20 of 43

1.

Identifying therapeutic targets in a combined EGFR-TGFβR signalling cascade using a multiscale agent-based cancer model.

Wang Z, Bordas V, Sagotsky J, Deisboeck TS.

Math Med Biol. 2012 Mar;29(1):95-108. doi: 10.1093/imammb/dqq023. Epub 2010 Dec 8.

2.

Systems biology and physiome projects.

Popel AS, Hunter PJ.

Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct;1(2):153-8. doi: 10.1002/wsbm.67. No abstract available.

3.

Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.

McDermott U, Settleman J.

J Clin Oncol. 2009 Nov 20;27(33):5650-9. doi: 10.1200/JCO.2009.22.9054. Epub 2009 Oct 26. Review.

PMID:
19858389
4.

Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model.

Wang Z, Birch CM, Sagotsky J, Deisboeck TS.

Bioinformatics. 2009 Sep 15;25(18):2389-96. doi: 10.1093/bioinformatics/btp416. Epub 2009 Jul 4.

5.

Advancing cancer systems biology: introducing the Center for the Development of a Virtual Tumor, CViT.

Deisboeck TS, Zhang L, Martin S.

Cancer Inform. 2007;5:1-8. Epub 2007 Mar 30.

6.

Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions.

Morabito A, Piccirillo MC, Falasconi F, De Feo G, Del Giudice A, Bryce J, Di Maio M, De Maio E, Normanno N, Perrone F.

Oncologist. 2009 Apr;14(4):378-90. doi: 10.1634/theoncologist.2008-0261. Epub 2009 Apr 6. Review.

7.

Equation-free multiscale computation: algorithms and applications.

Kevrekidis IG, Samaey G.

Annu Rev Phys Chem. 2009;60:321-44. doi: 10.1146/annurev.physchem.59.032607.093610. Review.

PMID:
19335220
8.

Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis.

Ramis-Conde I, Chaplain MA, Anderson AR, Drasdo D.

Phys Biol. 2009 Mar 25;6(1):016008. doi: 10.1088/1478-3975/6/1/016008.

PMID:
19321920
9.

The virtual cell--a candidate co-ordinator for 'middle-out' modelling of biological systems.

Walker DC, Southgate J.

Brief Bioinform. 2009 Jul;10(4):450-61. doi: 10.1093/bib/bbp010. Epub 2009 Mar 17. Review.

PMID:
19293250
10.

Evolution of cell motility in an individual-based model of tumour growth.

Gerlee P, Anderson AR.

J Theor Biol. 2009 Jul 7;259(1):67-83. doi: 10.1016/j.jtbi.2009.03.005. Epub 2009 Mar 12.

11.

Dual inhibition of the epidermal growth factor receptor pathway with cetuximab and erlotinib: a phase I study in patients with advanced solid malignancies.

Guarino MJ, Schneider CJ, Hosford MA, Brahmer JR, Rudin CM, Finckenstein FG, Philip-Norton RE, Lu H, Weber MR, Ettinger DS.

Oncologist. 2009 Feb;14(2):119-24. doi: 10.1634/theoncologist.2008-0124. Epub 2009 Jan 31.

12.

Multiscale agent-based cancer modeling.

Zhang L, Wang Z, Sagotsky JA, Deisboeck TS.

J Math Biol. 2009 Apr;58(4-5):545-59. doi: 10.1007/s00285-008-0211-1. Epub 2008 Sep 12.

PMID:
18787828
13.

Models from experiments: combinatorial drug perturbations of cancer cells.

Nelander S, Wang W, Nilsson B, She QB, Pratilas C, Rosen N, Gennemark P, Sander C.

Mol Syst Biol. 2008;4:216. doi: 10.1038/msb.2008.53. Epub 2008 Sep 2.

14.

Mathematical modelling of tumour acidity.

Smallbone K, Gatenby RA, Maini PK.

J Theor Biol. 2008 Nov 7;255(1):106-12. doi: 10.1016/j.jtbi.2008.08.002. Epub 2008 Aug 7.

PMID:
18725231
15.

Cross-scale sensitivity analysis of a non-small cell lung cancer model: linking molecular signaling properties to cellular behavior.

Wang Z, Birch CM, Deisboeck TS.

Biosystems. 2008 Jun;92(3):249-58. doi: 10.1016/j.biosystems.2008.03.002. Epub 2008 Mar 21.

16.

Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach.

Ramis-Conde I, Drasdo D, Anderson AR, Chaplain MA.

Biophys J. 2008 Jul;95(1):155-65. doi: 10.1529/biophysj.107.114678. Epub 2008 Mar 13.

17.

Simulating non-small cell lung cancer with a multiscale agent-based model.

Wang Z, Zhang L, Sagotsky J, Deisboeck TS.

Theor Biol Med Model. 2007 Dec 21;4:50.

18.

Proteins, drug targets and the mechanisms they control: the simple truth about complex networks.

Araujo RP, Liotta LA, Petricoin EF.

Nat Rev Drug Discov. 2007 Nov;6(11):871-80. Review.

PMID:
17932492
19.

Emerging drugs for non-small-cell lung cancer.

Felip E, Santarpia M, Rosell R.

Expert Opin Emerg Drugs. 2007 Sep;12(3):449-60. Review.

PMID:
17874972
20.

Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth.

Sanga S, Frieboes HB, Zheng X, Gatenby R, Bearer EL, Cristini V.

Neuroimage. 2007;37 Suppl 1:S120-34. Epub 2007 Jun 7. Review.

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