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Items: 1 to 20 of 45


Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay.

Edgeworth JA, Farmer M, Sicilia A, Tavares P, Beck J, Campbell T, Lowe J, Mead S, Rudge P, Collinge J, Jackson GS.

Lancet. 2011 Feb 5;377(9764):487-93. doi: 10.1016/S0140-6736(10)62308-2.


Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.

Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N.

Nat Med. 2011 Feb;17(2):175-8. doi: 10.1038/nm.2294. Epub 2011 Jan 30.


Superparamagnetic nanoparticle capture of prions for amplification.

Miller MB, Supattapone S.

J Virol. 2011 Mar;85(6):2813-7. doi: 10.1128/JVI.02451-10. Epub 2011 Jan 12.


Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

Wilham JM, Orrú CD, Bessen RA, Atarashi R, Sano K, Race B, Meade-White KD, Taubner LM, Timmes A, Caughey B.

PLoS Pathog. 2010 Dec 2;6(12):e1001217. doi: 10.1371/journal.ppat.1001217.


Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.

Khan MQ, Sweeting B, Mulligan VK, Arslan PE, Cashman NR, Pai EF, Chakrabartty A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19808-13. doi: 10.1073/pnas.1005267107. Epub 2010 Nov 1.


Variant Creutzfeldt-Jakob disease.

Ironside JW.

Haemophilia. 2010 Jul;16 Suppl 5:175-80. doi: 10.1111/j.1365-2516.2010.02317.x. Review.


Prion shedding from olfactory neurons into nasal secretions.

Bessen RA, Shearin H, Martinka S, Boharski R, Lowe D, Wilham JM, Caughey B, Wiley JA.

PLoS Pathog. 2010 Apr 15;6(4):e1000837. doi: 10.1371/journal.ppat.1000837.


A novel method for preclinical detection of PrPSc in blood.

Rubenstein R, Chang B, Gray P, Piltch M, Bulgin MS, Sorensen-Melson S, Miller MW.

J Gen Virol. 2010 Jul;91(Pt 7):1883-92. doi: 10.1099/vir.0.020164-0. Epub 2010 Mar 31.


Immunopurification of pathological prion protein aggregates.

Biasini E, Tapella L, Mantovani S, Stravalaci M, Gobbi M, Harris DA, Chiesa R.

PLoS One. 2009 Nov 12;4(11):e7816. doi: 10.1371/journal.pone.0007816.


Detection of PrPsc in blood from sheep infected with the scrapie and bovine spongiform encephalopathy agents.

Terry LA, Howells L, Hawthorn J, Edwards JC, Moore SJ, Bellworthy SJ, Simmons H, Lizano S, Estey L, Leathers V, Everest SJ.

J Virol. 2009 Dec;83(23):12552-8. doi: 10.1128/JVI.00311-09. Epub 2009 Sep 9.


Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein.

Orrú CD, Wilham JM, Hughson AG, Raymond LD, McNally KL, Bossers A, Ligios C, Caughey B.

Protein Eng Des Sel. 2009 Aug;22(8):515-21. doi: 10.1093/protein/gzp031. Epub 2009 Jul 1.


Hyperefficient PrP Sc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique.

Fujihara A, Atarashi R, Fuse T, Ubagai K, Nakagaki T, Yamaguchi N, Ishibashi D, Katamine S, Nishida N.

FEBS J. 2009 May;276(10):2841-8. doi: 10.1111/j.1742-4658.2009.07007.x.


Surround optical fiber immunoassay (SOFIA): an ultra-sensitive assay for prion protein detection.

Chang B, Gray P, Piltch M, Bulgin MS, Sorensen-Melson S, Miller MW, Davies P, Brown DR, Coughlin DR, Rubenstein R.

J Virol Methods. 2009 Jul;159(1):15-22. doi: 10.1016/j.jviromet.2009.02.019. Epub 2009 Feb 27.


Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.

Caughey B, Baron GS, Chesebro B, Jeffrey M.

Annu Rev Biochem. 2009;78:177-204. doi: 10.1146/annurev.biochem.78.082907.145410. Review.


Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.

Edgeworth JA, Jackson GS, Clarke AR, Weissmann C, Collinge J.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3479-83. doi: 10.1073/pnas.0813342106. Epub 2009 Feb 9.


In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie.

Thorne L, Terry LA.

J Gen Virol. 2008 Dec;89(Pt 12):3177-84. doi: 10.1099/vir.0.2008/004226-0.


Human platelets as a substrate source for the in vitro amplification of the abnormal prion protein (PrP) associated with variant Creutzfeldt-Jakob disease.

Jones M, Peden AH, Yull H, Wight D, Bishop MT, Prowse CV, Turner ML, Ironside JW, MacGregor IR, Head MW.

Transfusion. 2009 Feb;49(2):376-84. doi: 10.1111/j.1537-2995.2008.01954.x. Epub 2008 Oct 29.


Prion diseases are efficiently transmitted by blood transfusion in sheep.

Houston F, McCutcheon S, Goldmann W, Chong A, Foster J, Sisó S, González L, Jeffrey M, Hunter N.

Blood. 2008 Dec 1;112(12):4739-45. doi: 10.1182/blood-2008-04-152520. Epub 2008 Jul 22.


Spontaneous and BSE-prion-seeded amyloid formation of full length recombinant bovine prion protein.

Panza G, Stöhr J, Dumpitak C, Papathanassiou D, Weiss J, Riesner D, Willbold D, Birkmann E.

Biochem Biophys Res Commun. 2008 Sep 5;373(4):493-7. doi: 10.1016/j.bbrc.2008.06.059. Epub 2008 Jun 26.


A highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease.

Birkmann E, Henke F, Funke SA, Bannach O, Riesner D, Willbold D.

Rejuvenation Res. 2008 Apr;11(2):359-63. doi: 10.1089/rej.2008.0697.


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