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Items: 1 to 20 of 58

1.

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.

Han X, Mann E, Gilbert S, Guan Y, Steinbrecher KA, Montrose MH, Cohen MB.

PLoS One. 2011 Jan 31;6(1):e16139. doi: 10.1371/journal.pone.0016139.

2.

Importance and regulation of the colonic mucus barrier in a mouse model of colitis.

Petersson J, Schreiber O, Hansson GC, Gendler SJ, Velcich A, Lundberg JO, Roos S, Holm L, Phillipson M.

Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G327-33. doi: 10.1152/ajpgi.00422.2010.

3.

Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation.

Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, O'Dea C, Baird M, Lembo AJ.

Gastroenterology. 2010 Dec;139(6):1877-1886.e2. doi: 10.1053/j.gastro.2010.08.041.

PMID:
20801122
4.

Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways.

Nava P, Koch S, Laukoetter MG, Lee WY, Kolegraff K, Capaldo CT, Beeman N, Addis C, Gerner-Smidt K, Neumaier I, Skerra A, Li L, Parkos CA, Nusrat A.

Immunity. 2010 Mar 26;32(3):392-402. doi: 10.1016/j.immuni.2010.03.001.

5.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS.

Cancer Res. 2010 Apr 1;70(7):2634-43. doi: 10.1158/0008-5472.CAN-09-3465.

6.

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.

Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K.

J Immunol. 2010 Apr 1;184(7):3743-54. doi: 10.4049/jimmunol.0903164.

7.

Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injury.

Kiela PR, Laubitz D, Larmonier CB, Midura-Kiela MT, Lipko MA, Janikashvili N, Bai A, Thurston R, Ghishan FK.

Gastroenterology. 2009 Sep;137(3):965-75, 975.e1-10. doi: 10.1053/j.gastro.2009.05.043.

8.

CFTR is a negative regulator of NFkappaB mediated innate immune response.

Vij N, Mazur S, Zeitlin PL.

PLoS One. 2009;4(2):e4664. doi: 10.1371/journal.pone.0004664.

9.

Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis.

Garin-Laflam MP, Steinbrecher KA, Rudolph JA, Mao J, Cohen MB.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G740-9. doi: 10.1152/ajpgi.90268.2008.

10.

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.

Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M.

Cancer Cell. 2009 Feb 3;15(2):103-13. doi: 10.1016/j.ccr.2009.01.001. Erratum in: Cancer Cell. 2009 Mar 3;15(3):241.

11.

Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans.

Möndel M, Schroeder BO, Zimmermann K, Huber H, Nuding S, Beisner J, Fellermann K, Stange EF, Wehkamp J.

Mucosal Immunol. 2009 Mar;2(2):166-72. doi: 10.1038/mi.2008.77.

PMID:
19129752
12.

Pilot study on the effect of linaclotide in patients with chronic constipation.

Johnston JM, Kurtz CB, Drossman DA, Lembo AJ, Jeglinski BI, MacDougall JE, Antonelli SM, Currie MG.

Am J Gastroenterol. 2009 Jan;104(1):125-32. doi: 10.1038/ajg.2008.59.

PMID:
19098860
13.
14.

Suppression of experimental colitis in mice by CD11c+ dendritic cells.

Qualls JE, Tuna H, Kaplan AM, Cohen DA.

Inflamm Bowel Dis. 2009 Feb;15(2):236-47. doi: 10.1002/ibd.20733.

PMID:
18839426
15.

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse.

Arrieta MC, Madsen K, Doyle J, Meddings J.

Gut. 2009 Jan;58(1):41-8. doi: 10.1136/gut.2008.150888.

16.

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation.

Nair MG, Guild KJ, Du Y, Zaph C, Yancopoulos GD, Valenzuela DM, Murphy A, Stevens S, Karow M, Artis D.

J Immunol. 2008 Oct 1;181(7):4709-15.

17.

Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis.

Shea-Donohue T, Thomas K, Cody MJ, Aiping Zhao, Detolla LJ, Kopydlowski KM, Fukata M, Lira SA, Vogel SN.

Innate Immun. 2008 Apr;14(2):117-24. doi: 10.1177/1753425908088724.

18.

Diarrhea as a cause of mortality in a mouse model of infectious colitis.

Borenshtein D, Fry RC, Groff EB, Nambiar PR, Carey VJ, Fox JG, Schauer DB.

Genome Biol. 2008;9(8):R122. doi: 10.1186/gb-2008-9-8-r122.

19.

Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis.

Laubitz D, Larmonier CB, Bai A, Midura-Kiela MT, Lipko MA, Thurston RD, Kiela PR, Ghishan FK.

Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G63-G77. doi: 10.1152/ajpgi.90207.2008.

20.

Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice.

Krimi RB, Kotelevets L, Dubuquoy L, Plaisancié P, Walker F, Lehy T, Desreumaux P, Van Seuningen I, Chastre E, Forgue-Lafitte ME, Marie JC.

Inflamm Bowel Dis. 2008 Jul;14(7):931-41. doi: 10.1002/ibd.20420.

PMID:
18300276
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