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Items: 1 to 20 of 45

1.

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.

Sun Z, Diaz Z, Fang X, Hart MP, Chesi A, Shorter J, Gitler AD.

PLoS Biol. 2011 Apr;9(4):e1000614. doi: 10.1371/journal.pbio.1000614. Epub 2011 Apr 26.

2.

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.

Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD.

Nature. 2010 Aug 26;466(7310):1069-75. doi: 10.1038/nature09320.

3.

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.

Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ Jr, Sapp P, McKenna-Yasek D, Brown RH Jr, Hayward LJ.

Hum Mol Genet. 2010 Nov 1;19(21):4160-75. doi: 10.1093/hmg/ddq335. Epub 2010 Aug 10.

4.

Novel missense and truncating mutations in FUS/TLS in familial ALS.

Waibel S, Neumann M, Rabe M, Meyer T, Ludolph AC.

Neurology. 2010 Aug 31;75(9):815-7. doi: 10.1212/WNL.0b013e3181f07e26. Epub 2010 Jul 21.

PMID:
20660363
5.

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C.

EMBO J. 2010 Aug 18;29(16):2841-57. doi: 10.1038/emboj.2010.143. Epub 2010 Jul 6.

6.

Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.

Rademakers R, Stewart H, Dejesus-Hernandez M, Krieger C, Graff-Radford N, Fabros M, Briemberg H, Cashman N, Eisen A, Mackenzie IR.

Muscle Nerve. 2010 Aug;42(2):170-6. doi: 10.1002/mus.21665.

7.

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.

Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T.

Ann Neurol. 2010 Jun;67(6):739-48. doi: 10.1002/ana.22051.

8.

Mutations of optineurin in amyotrophic lateral sclerosis.

Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H.

Nature. 2010 May 13;465(7295):223-6. doi: 10.1038/nature08971. Epub 2010 Apr 28.

PMID:
20428114
9.

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

Khurana V, Lindquist S.

Nat Rev Neurosci. 2010 Jun;11(6):436-49. doi: 10.1038/nrn2809. Epub 2010 Apr 28. Review.

PMID:
20424620
10.

From FUS to Fibs: what's new in frontotemporal dementia?

Burrell JR, Hodges JR.

J Alzheimers Dis. 2010;21(2):349-60. doi: 10.3233/JAD-2010-091513. Review.

PMID:
20413882
11.

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

Hewitt C, Kirby J, Highley JR, Hartley JA, Hibberd R, Hollinger HC, Williams TL, Ince PG, McDermott CJ, Shaw PJ.

Arch Neurol. 2010 Apr;67(4):455-61. doi: 10.1001/archneurol.2010.52.

PMID:
20385912
12.

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond.

Ilieva H, Polymenidou M, Cleveland DW.

J Cell Biol. 2009 Dec 14;187(6):761-72. doi: 10.1083/jcb.200908164. Review.

13.

The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases.

Doi H, Koyano S, Suzuki Y, Nukina N, Kuroiwa Y.

Neurosci Res. 2010 Jan;66(1):131-3. doi: 10.1016/j.neures.2009.10.004. Epub 2009 Oct 13.

PMID:
19833157
14.

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.

Pesiridis GS, Lee VM, Trojanowski JQ.

Hum Mol Genet. 2009 Oct 15;18(R2):R156-62. doi: 10.1093/hmg/ddp303. Review.

15.

A new subtype of frontotemporal lobar degeneration with FUS pathology.

Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR.

Brain. 2009 Nov;132(Pt 11):2922-31. doi: 10.1093/brain/awp214. Epub 2009 Aug 11.

16.

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.

Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR.

Acta Neuropathol. 2009 Nov;118(5):605-16. doi: 10.1007/s00401-009-0581-5. Epub 2009 Aug 9.

17.

Rethinking ALS: the FUS about TDP-43.

Lagier-Tourenne C, Cleveland DW.

Cell. 2009 Mar 20;136(6):1001-4. doi: 10.1016/j.cell.2009.03.006. Review.

18.

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.

Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE.

Science. 2009 Feb 27;323(5918):1208-11. doi: 10.1126/science.1165942.

19.

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.

Science. 2009 Feb 27;323(5918):1205-8. doi: 10.1126/science.1166066.

20.

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.

Rothstein JD.

Ann Neurol. 2009 Jan;65 Suppl 1:S3-9. doi: 10.1002/ana.21543. Review.

PMID:
19191304

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