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Items: 1 to 20 of 24


Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs.

Kerrigan AM, Brown GD.

Immunol Rev. 2010 Mar;234(1):335-52. doi: 10.1111/j.0105-2896.2009.00882.x. Review.


Functional anatomy of T cell activation and synapse formation.

Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair DA, Waite J, Sacristán C, Victora GD, Zanin-Zhorov A, Dustin ML.

Annu Rev Immunol. 2010;28:79-105. doi: 10.1146/annurev-immunol-030409-101308. Review.


Human dectin-1 deficiency and mucocutaneous fungal infections.

Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, Jacobs L, Jansen T, Verheijen K, Masthoff L, Morré SA, Vriend G, Williams DL, Perfect JR, Joosten LA, Wijmenga C, van der Meer JW, Adema GJ, Kullberg BJ, Brown GD, Netea MG.

N Engl J Med. 2009 Oct 29;361(18):1760-7. doi: 10.1056/NEJMoa0901053.


Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients.

Plantinga TS, van der Velden WJ, Ferwerda B, van Spriel AB, Adema G, Feuth T, Donnelly JP, Brown GD, Kullberg BJ, Blijlevens NM, Netea MG.

Clin Infect Dis. 2009 Sep 1;49(5):724-32. doi: 10.1086/604714.


Beta-glucan recognition by the innate immune system.

Goodridge HS, Wolf AJ, Underhill DM.

Immunol Rev. 2009 Jul;230(1):38-50. doi: 10.1111/j.1600-065X.2009.00793.x. Review.


CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

Kerrigan AM, Dennehy KM, Mourão-Sá D, Faro-Trindade I, Willment JA, Taylor PR, Eble JA, Reis e Sousa C, Brown GD.

J Immunol. 2009 Apr 1;182(7):4150-7. doi: 10.4049/jimmunol.0802808.


CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells.

Hermiston ML, Zikherman J, Zhu JW.

Immunol Rev. 2009 Mar;228(1):288-311. doi: 10.1111/j.1600-065X.2008.00752.x. Review. Erratum in: Immunol Rev. 2009 May;229(1):387.


Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.

Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM.

J Immunol. 2009 Jan 15;182(2):1146-54.


Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.

Zhu JW, Brdicka T, Katsumoto TR, Lin J, Weiss A.

Immunity. 2008 Feb;28(2):183-96. doi: 10.1016/j.immuni.2007.11.024. Epub 2008 Jan 31.


Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.

Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer-Wentrup F, Adema GJ, Kullberg BJ, Schweighoffer E, Tybulewicz V, Mora-Montes HM, Gow NA, Williams DL, Netea MG, Brown GD.

Eur J Immunol. 2008 Feb;38(2):500-6. doi: 10.1002/eji.200737741.


Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching.

Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, Gordon S, Monteiro MA, Papp-Szabo E, Lowman DW, Power TD, Wempe MF, Williams DL.

J Pharmacol Exp Ther. 2008 Apr;325(1):115-23. doi: 10.1124/jpet.107.133124. Epub 2008 Jan 2.


Stepping into the third dimension.

Feng D, Marshburn D, Jen D, Weinberg RJ, Taylor RM 2nd, Burette A.

J Neurosci. 2007 Nov 21;27(47):12757-60. Review.


The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.

Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pöhlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP, Pearce AC.

J Biol Chem. 2007 Apr 27;282(17):12397-409. Epub 2007 Mar 5.


Dectin-1 is required for beta-glucan recognition and control of fungal infection.

Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, Brown GD.

Nat Immunol. 2007 Jan;8(1):31-8. Epub 2006 Dec 10.


Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.

Saijo S, Fujikado N, Furuta T, Chung SH, Kotaki H, Seki K, Sudo K, Akira S, Adachi Y, Ohno N, Kinjo T, Nakamura K, Kawakami K, Iwakura Y.

Nat Immunol. 2007 Jan;8(1):39-46. Epub 2006 Dec 10.


Beta-glucan is a fungal determinant for adhesion-dependent human neutrophil functions.

Lavigne LM, Albina JE, Reichner JS.

J Immunol. 2006 Dec 15;177(12):8667-75.


Myeloid C-type lectins in innate immunity.

Robinson MJ, Sancho D, Slack EC, LeibundGut-Landmann S, Reis e Sousa C.

Nat Immunol. 2006 Dec;7(12):1258-65. Review.


Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.

Underhill DM, Rossnagle E, Lowell CA, Simmons RM.

Blood. 2005 Oct 1;106(7):2543-50. Epub 2005 Jun 14.


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