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Items: 1 to 20 of 48


BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways.

Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M.

J Cell Biol. 2011 Jan 10;192(1):171-88. doi: 10.1083/jcb.201008060.


COMP-Ang1 stimulates HIF-1α-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment.

Youn SW, Lee SW, Lee J, Jeong HK, Suh JW, Yoon CH, Kang HJ, Kim HZ, Koh GY, Oh BH, Park YB, Kim HS.

Blood. 2011 Apr 21;117(16):4376-86. doi: 10.1182/blood-2010-07-295964. Epub 2011 Jan 3.


Integrin signalling adaptors: not only figurants in the cancer story.

Cabodi S, del Pilar Camacho-Leal M, Di Stefano P, Defilippi P.

Nat Rev Cancer. 2010 Dec;10(12):858-70. doi: 10.1038/nrc2967. Epub 2010 Nov 24. Review.


Pseudokinases-remnants of evolution or key allosteric regulators?

Zeqiraj E, van Aalten DM.

Curr Opin Struct Biol. 2010 Dec;20(6):772-81. doi: 10.1016/ Epub 2010 Nov 10. Review.


Protein kinases: evolution of dynamic regulatory proteins.

Taylor SS, Kornev AP.

Trends Biochem Sci. 2011 Feb;36(2):65-77. doi: 10.1016/j.tibs.2010.09.006. Epub 2010 Oct 23. Review.


Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation.

Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE, Foster LJ, Ish-Horowicz D, Walsh MP, Dedhar S.

PLoS One. 2010 Aug 23;5(8):e12356. doi: 10.1371/journal.pone.0012356.


Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.

Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R.

Development. 2010 Oct;137(19):3233-43. doi: 10.1242/dev.052845.


Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ.

Oncogene. 2010 Jun 10;29(23):3374-85. doi: 10.1038/onc.2010.86. Epub 2010 Mar 22.


The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

Wickström SA, Lange A, Montanez E, Fässler R.

EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24. Review.


The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions.

Fukuda K, Gupta S, Chen K, Wu C, Qin J.

Mol Cell. 2009 Dec 11;36(5):819-30. doi: 10.1016/j.molcel.2009.11.028.


Integrin-linked kinase is an adaptor with essential functions during mouse development.

Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R.

Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.


Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction.

Ding L, Dong L, Chen X, Zhang L, Xu X, Ferro A, Xu B.

Circulation. 2009 Sep 1;120(9):764-73. doi: 10.1161/CIRCULATIONAHA.109.870725. Epub 2009 Aug 17.


ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.

PLoS Biol. 2009 Jun 9;7(6):e1000126. doi: 10.1371/journal.pbio.1000126. Epub 2009 Jun 9.


ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.

Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF.

Structure. 2009 Jan 14;17(1):139-46. doi: 10.1016/j.str.2008.11.005.


Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.

Scheeff ED, Eswaran J, Bunkoczi G, Knapp S, Manning G.

Structure. 2009 Jan 14;17(1):128-38. doi: 10.1016/j.str.2008.10.018.


Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.

Yang Y, Wang X, Hawkins CA, Chen K, Vaynberg J, Mao X, Tu Y, Zuo X, Wang J, Wang YX, Wu C, Tjandra N, Qin J.

J Biol Chem. 2009 Feb 27;284(9):5836-44. doi: 10.1074/jbc.M805319200. Epub 2008 Dec 30.


Scaffold proteins and immune-cell signalling.

Shaw AS, Filbert EL.

Nat Rev Immunol. 2009 Jan;9(1):47-56. doi: 10.1038/nri2473. Review.


The structural basis of integrin-linked kinase-PINCH interactions.

Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20677-82. doi: 10.1073/pnas.0811415106. Epub 2008 Dec 12.


Integrin-linked kinase--essential roles in physiology and cancer biology.

McDonald PC, Fielding AB, Dedhar S.

J Cell Sci. 2008 Oct 1;121(Pt 19):3121-32. doi: 10.1242/jcs.017996. Review.


The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly.

Wang X, Fukuda K, Byeon IJ, Velyvis A, Wu C, Gronenborn A, Qin J.

J Biol Chem. 2008 Jul 25;283(30):21113-9. doi: 10.1074/jbc.M801270200. Epub 2008 May 28.

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