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Items: 1 to 20 of 52

1.

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.

Scherzer-Attali R, Pellarin R, Convertino M, Frydman-Marom A, Egoz-Matia N, Peled S, Levy-Sakin M, Shalev DE, Caflisch A, Gazit E, Segal D.

PLoS One. 2010 Jun 14;5(6):e11101. doi: 10.1371/journal.pone.0011101.

2.

Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils.

Paravastu AK, Leapman RD, Yau WM, Tycko R.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54. doi: 10.1073/pnas.0806270105. Epub 2008 Nov 17.

3.

Trp/Met/Phe hot spots in protein-protein interactions: potential targets in drug design.

Ma B, Nussinov R.

Curr Top Med Chem. 2007;7(10):999-1005. Review.

PMID:
17508933
4.

Atomic structures of amyloid cross-beta spines reveal varied steric zippers.

Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D.

Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29.

PMID:
17468747
5.

Aromatic interactions are not required for amyloid fibril formation by islet amyloid polypeptide but do influence the rate of fibril formation and fibril morphology.

Marek P, Abedini A, Song B, Kanungo M, Johnson ME, Gupta R, Zaman W, Wong SS, Raleigh DP.

Biochemistry. 2007 Mar 20;46(11):3255-61. Epub 2007 Feb 21.

PMID:
17311418
6.

The minimal amyloid-forming fragment of the islet amyloid polypeptide is a glycolipid-binding domain.

Levy M, Garmy N, Gazit E, Fantini J.

FEBS J. 2006 Dec;273(24):5724-35. Erratum in: FEBS J. 2007 Apr;274(7):1878.

7.

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide.

Kim W, Kim Y, Min J, Kim DJ, Chang YT, Hecht MH.

ACS Chem Biol. 2006 Aug 22;1(7):461-9.

PMID:
17168524
8.

Alzheimer's discovery.

Dahm R.

Curr Biol. 2006 Nov 7;16(21):R906-10. No abstract available.

9.

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide.

Kim W, Hecht MH.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15824-9. Epub 2006 Oct 12.

10.

Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase.

Bemporad F, Taddei N, Stefani M, Chiti F.

Protein Sci. 2006 Apr;15(4):862-70.

11.

Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide.

Paravastu AK, Petkova AT, Tycko R.

Biophys J. 2006 Jun 15;90(12):4618-29. Epub 2006 Mar 24.

12.

A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.

PMID:
16541076
13.
14.
15.

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils.

Petkova AT, Yau WM, Tycko R.

Biochemistry. 2006 Jan 17;45(2):498-512.

17.

Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.

Kim W, Hecht MH.

J Biol Chem. 2005 Oct 14;280(41):35069-76. Epub 2005 Aug 3.

18.

Structure of the cross-beta spine of amyloid-like fibrils.

Nelson R, Sawaya MR, Balbirnie M, Madsen AØ, Riekel C, Grothe R, Eisenberg D.

Nature. 2005 Jun 9;435(7043):773-8.

19.

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R.

Science. 2005 Jan 14;307(5707):262-5.

20.

Role of aromatic interactions in amyloid formation by peptides derived from human Amylin.

Tracz SM, Abedini A, Driscoll M, Raleigh DP.

Biochemistry. 2004 Dec 21;43(50):15901-8.

PMID:
15595845

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