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Items: 1 to 20 of 39


Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL.

Nature. 2010 Apr 22;464(7292):1149-54. doi: 10.1038/nature08894. Epub 2010 Apr 4.


Direct conversion of fibroblasts to functional neurons by defined factors.

Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M.

Nature. 2010 Feb 25;463(7284):1035-41. doi: 10.1038/nature08797. Epub 2010 Jan 27.


Direct cell reprogramming is a stochastic process amenable to acceleration.

Hanna J, Saha K, Pando B, van Zon J, Lengner CJ, Creyghton MP, van Oudenaarden A, Jaenisch R.

Nature. 2009 Dec 3;462(7273):595-601. doi: 10.1038/nature08592. Epub 2009 Nov 8.


The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A.

Cell. 2009 Aug 7;138(3):449-62. doi: 10.1016/j.cell.2009.05.035.


Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

Dhawan S, Tschen SI, Bhushan A.

Genes Dev. 2009 Apr 15;23(8):906-11. doi: 10.1101/gad.1742609.


Adaptive beta-cell proliferation is severely restricted with advanced age.

Rankin MM, Kushner JA.

Diabetes. 2009 Jun;58(6):1365-72. doi: 10.2337/db08-1198. Epub 2009 Mar 5.


Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.

Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M.

Mol Cell. 2009 Feb 27;33(4):417-27. doi: 10.1016/j.molcel.2009.02.004.


Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.

Tschen SI, Dhawan S, Gurlo T, Bhushan A.

Diabetes. 2009 Jun;58(6):1312-20. doi: 10.2337/db08-1651. Epub 2009 Feb 19.


Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.

Ng RK, Dean W, Dawson C, Lucifero D, Madeja Z, Reik W, Hemberger M.

Nat Cell Biol. 2008 Nov;10(11):1280-90. doi: 10.1038/ncb1786. Epub 2008 Oct 5.


In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA.

Nature. 2008 Oct 2;455(7213):627-32. doi: 10.1038/nature07314. Epub 2008 Aug 27.


MicroChIP--a rapid micro chromatin immunoprecipitation assay for small cell samples and biopsies.

Dahl JA, Collas P.

Nucleic Acids Res. 2008 Feb;36(3):e15. doi: 10.1093/nar/gkm1158. Epub 2008 Jan 17.


PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation.

Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, Hsieh J, Bauer UM.

Genes Dev. 2007 Dec 15;21(24):3369-80.


Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.

Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Vermeulen M, Mann M, Bähler J, Green RD, Kouzarides T.

Nature. 2007 Oct 18;449(7164):928-32. Epub 2007 Sep 26.


Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.

Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, Lüscher B, Amati B.

Nature. 2007 Oct 18;449(7164):933-7. Epub 2007 Sep 26.


Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.

Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A.

J Clin Invest. 2007 Oct;117(10):2869-76.


DNA methylation: the nuts and bolts of repression.

Miranda TB, Jones PA.

J Cell Physiol. 2007 Nov;213(2):384-90. Review.


All beta cells contribute equally to islet growth and maintenance.

Brennand K, Huangfu D, Melton D.

PLoS Biol. 2007 Jul;5(7):e163. Epub 2007 May 29.


Growth and regeneration of adult beta cells does not involve specialized progenitors.

Teta M, Rankin MM, Long SY, Stein GM, Kushner JA.

Dev Cell. 2007 May;12(5):817-26.


Mechanisms of epigenetic inheritance.

Martin C, Zhang Y.

Curr Opin Cell Biol. 2007 Jun;19(3):266-72. Epub 2007 Apr 26. Review.


Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A.

J Clin Invest. 2007 Apr;117(4):961-70.

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