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Items: 1 to 20 of 57

1.

Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.

Kirouac KN, Ling H.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3210-5. doi: 10.1073/pnas.1013909108.

2.

DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

J Mol Biol. 2011 Feb 11;406(1):18-28. doi: 10.1016/j.jmb.2010.12.016.

3.

Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase η.

Silverstein TD, Jain R, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Structure. 2010 Nov 10;18(11):1463-70. doi: 10.1016/j.str.2010.08.019.

4.

Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus.

Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1013-8. doi: 10.1107/S1744309110029374.

5.

Structure and mechanism of human DNA polymerase eta.

Biertümpfel C, Zhao Y, Kondo Y, Ramón-Maiques S, Gregory M, Lee JY, Masutani C, Lehmann AR, Hanaoka F, Yang W.

Nature. 2010 Jun 24;465(7301):1044-8. doi: 10.1038/nature09196. Erratum in: Nature. 2011 Aug 18;476(7360):360.

6.

Structural basis for the suppression of skin cancers by DNA polymerase eta.

Silverstein TD, Johnson RE, Jain R, Prakash L, Prakash S, Aggarwal AK.

Nature. 2010 Jun 24;465(7301):1039-43. doi: 10.1038/nature09104.

7.

Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site.

Batra VK, Beard WA, Hou EW, Pedersen LC, Prasad R, Wilson SH.

Nat Struct Mol Biol. 2010 Jul;17(7):889-90. doi: 10.1038/nsmb.1852.

8.

Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine .

Beckman J, Wang M, Blaha G, Wang J, Konigsberg WH.

Biochemistry. 2010 May 18;49(19):4116-25. doi: 10.1021/bi100102s.

9.

Replication through an abasic DNA lesion: structural basis for adenine selectivity.

Obeid S, Blatter N, Kranaster R, Schnur A, Diederichs K, Welte W, Marx A.

EMBO J. 2010 May 19;29(10):1738-47. doi: 10.1038/emboj.2010.64.

10.

Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69.

Hogg M, Rudnicki J, Midkiff J, Reha-Krantz L, Doublié S, Wallace SS.

Biochemistry. 2010 Mar 23;49(11):2317-25. doi: 10.1021/bi901488d.

11.

Structural insight into translesion synthesis by DNA Pol II.

Wang F, Yang W.

Cell. 2009 Dec 24;139(7):1279-89. doi: 10.1016/j.cell.2009.11.043.

12.

DNA polymerase beta substrate specificity: side chain modulation of the "A-rule".

Beard WA, Shock DD, Batra VK, Pedersen LC, Wilson SH.

J Biol Chem. 2009 Nov 13;284(46):31680-9. doi: 10.1074/jbc.M109.029843.

13.
14.

Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.

Vasquez-Del Carpio R, Silverstein TD, Lone S, Swan MK, Choudhury JR, Johnson RE, Prakash S, Prakash L, Aggarwal AK.

PLoS One. 2009 Jun 2;4(6):e5766. doi: 10.1371/journal.pone.0005766.

15.

DNA synthesis across an abasic lesion by human DNA polymerase iota.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Structure. 2009 Apr 15;17(4):530-7. doi: 10.1016/j.str.2009.02.015.

16.

Y-family DNA polymerases in mammalian cells.

Guo C, Kosarek-Stancel JN, Tang TS, Friedberg EC.

Cell Mol Life Sci. 2009 Jul;66(14):2363-81. doi: 10.1007/s00018-009-0024-4. Review.

PMID:
19367366
17.

Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance.

Waters LS, Minesinger BK, Wiltrout ME, D'Souza S, Woodruff RV, Walker GC.

Microbiol Mol Biol Rev. 2009 Mar;73(1):134-54. doi: 10.1128/MMBR.00034-08. Review.

18.

DNA polymerases and human disease.

Loeb LA, Monnat RJ Jr.

Nat Rev Genet. 2008 Aug;9(8):594-604. doi: 10.1038/nrg2345. Review.

PMID:
18626473
19.
20.

Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH.

Mol Cell. 2008 May 9;30(3):315-24. doi: 10.1016/j.molcel.2008.02.025.

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