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Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.

Chen S, Wasserman DH, MacKintosh C, Sakamoto K.

Cell Metab. 2011 Jan 5;13(1):68-79. doi: 10.1016/j.cmet.2010.12.005.


Insulin controls the spatial distribution of GLUT4 on the cell surface through regulation of its postfusion dispersal.

Stenkula KG, Lizunov VA, Cushman SW, Zimmerberg J.

Cell Metab. 2010 Sep 8;12(3):250-9. doi: 10.1016/j.cmet.2010.08.005.


Analysis of TBC1D4 in patients with severe insulin resistance.

Dash S, Langenberg C, Fawcett KA, Semple RK, Romeo S, Sharp S, Sano H, Lienhard GE, Rochford JJ, Howlett T, Massoud AF, Hindmarsh P, Howell SJ, Wilkinson RJ, Lyssenko V, Groop L, Baroni MG, Barroso I, Wareham NJ, O'Rahilly S, Savage DB.

Diabetologia. 2010 Jun;53(6):1239-42. doi: 10.1007/s00125-010-1724-x. Epub 2010 Mar 27. No abstract available.


Whole-genome resequencing reveals loci under selection during chicken domestication.

Rubin CJ, Zody MC, Eriksson J, Meadows JR, Sherwood E, Webster MT, Jiang L, Ingman M, Sharpe T, Ka S, Hallböök F, Besnier F, Carlborg O, Bed'hom B, Tixier-Boichard M, Jensen P, Siegel P, Lindblad-Toh K, Andersson L.

Nature. 2010 Mar 25;464(7288):587-91. doi: 10.1038/nature08832. Epub 2010 Mar 10.


Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferation.

Liang S, Xu Y, Shen G, Liu Q, Zhao X, Xu Z, Xie X, Gong F, Li R, Wei Y.

Electrophoresis. 2009 Dec;30(23):4152-62. doi: 10.1002/elps.200900249.


A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CS, Soos MA, Clark J, Rodin A, Langenberg C, Druet C, Fawcett KA, Tung YC, Wareham NJ, Barroso I, Lienhard GE, O'Rahilly S, Savage DB.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. doi: 10.1073/pnas.0900909106. Epub 2009 May 22.


CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.

Yip MF, Ramm G, Larance M, Hoehn KL, Wagner MC, Guilhaus M, James DE.

Cell Metab. 2008 Nov;8(5):384-98. doi: 10.1016/j.cmet.2008.09.011.


Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schürmann A, Joost HG, Al-Hasani H.

Nat Genet. 2008 Nov;40(11):1354-9. doi: 10.1038/ng.244. Epub 2008 Oct 19.


Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.

Stöckli J, Davey JR, Hohnen-Behrens C, Xu A, James DE, Ramm G.

Mol Endocrinol. 2008 Dec;22(12):2703-15. doi: 10.1210/me.2008-0111. Epub 2008 Sep 18.


Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic.

Sakamoto K, Holman GD.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E29-37. doi: 10.1152/ajpendo.90331.2008. Epub 2008 May 13. Review.


R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.

Meyre D, Farge M, Lecoeur C, Proenca C, Durand E, Allegaert F, Tichet J, Marre M, Balkau B, Weill J, Delplanque J, Froguel P.

Hum Mol Genet. 2008 Jun 15;17(12):1798-802. doi: 10.1093/hmg/ddn070. Epub 2008 Mar 5.


Rab10 in insulin-stimulated GLUT4 translocation.

Sano H, Roach WG, Peck GR, Fukuda M, Lienhard GE.

Biochem J. 2008 Apr 1;411(1):89-95.


Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles.

Jiang L, Fan J, Bai L, Wang Y, Chen Y, Yang L, Chen L, Xu T.

J Biol Chem. 2008 Mar 28;283(13):8508-16. Epub 2007 Dec 6.


The Pfam protein families database.

Finn RD, Tate J, Mistry J, Coggill PC, Sammut SJ, Hotz HR, Ceric G, Forslund K, Eddy SR, Sonnhammer EL, Bateman A.

Nucleic Acids Res. 2008 Jan;36(Database issue):D281-8. Epub 2007 Nov 26.


Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.

Chen S, Murphy J, Toth R, Campbell DG, Morrice NA, Mackintosh C.

Biochem J. 2008 Jan 15;409(2):449-59.


Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

Geraghty KM, Chen S, Harthill JE, Ibrahim AF, Toth R, Morrice NA, Vandermoere F, Moorhead GB, Hardie DG, MacKintosh C.

Biochem J. 2007 Oct 15;407(2):231-41.


Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE.

Cell Metab. 2007 Apr;5(4):293-303.


Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes.

Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP.

Mol Cell Biol. 2007 May;27(9):3456-69. Epub 2007 Mar 5.


Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.

Bai L, Wang Y, Fan J, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T.

Cell Metab. 2007 Jan;5(1):47-57.

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