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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.

Kalid O, Mense M, Fischman S, Shitrit A, Bihler H, Ben-Zeev E, Schutz N, Pedemonte N, Thomas PJ, Bridges RJ, Wetmore DR, Marantz Y, Senderowitz H.

J Comput Aided Mol Des. 2010 Dec;24(12):971-91. doi: 10.1007/s10822-010-9390-0. Epub 2010 Oct 26.


Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.

Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L.

Am J Pathol. 2010 Aug;177(2):563-9. doi: 10.2353/ajpath.2010.090973. Epub 2010 Jul 1.


Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.

Huang Y.

Trends Mol Med. 2010 Jun;16(6):287-94. doi: 10.1016/j.molmed.2010.04.004. Epub 2010 May 27. Review.


ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS.

J Neurosci. 2009 Dec 2;29(48):15317-22. doi: 10.1523/JNEUROSCI.4026-09.2009.


GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.

Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y.

Cell Stem Cell. 2009 Dec 4;5(6):634-45. doi: 10.1016/j.stem.2009.10.015.


Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function.

Zhong N, Ramaswamy G, Weisgraber KH.

J Biol Chem. 2009 Oct 2;284(40):27273-80. doi: 10.1074/jbc.M109.014464. Epub 2009 Aug 7.


Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.

Zhong N, Weisgraber KH.

J Biol Chem. 2009 Mar 6;284(10):6027-31. doi: 10.1074/jbc.R800009200. Epub 2008 Oct 22. Review.


Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.

Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y.

J Neurosci. 2008 Feb 6;28(6):1452-9. doi: 10.1523/JNEUROSCI.3253-07.2008.


Protein quality control in the early secretory pathway.

Anelli T, Sitia R.

EMBO J. 2008 Jan 23;27(2):315-27. doi: 10.1038/sj.emboj.7601974. Review.


Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1343-6. doi: 10.1073/pnas.0709906104. Epub 2008 Jan 22.


Restoration of p53 to limit tumor growth.

Wang W, El-Deiry WS.

Curr Opin Oncol. 2008 Jan;20(1):90-6. Review.


Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.

Huang Y.

Curr Opin Drug Discov Devel. 2006 Sep;9(5):627-41. Review.


Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Mahley RW, Weisgraber KH, Huang Y.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5644-51. Epub 2006 Mar 27. Review.


Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18694-9. Epub 2005 Dec 12.


Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5. Epub 2005 Dec 12.


Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4.

Hatters DM, Peters-Libeu CA, Weisgraber KH.

J Biol Chem. 2005 Jul 15;280(28):26477-82. Epub 2005 May 11.


Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y.

J Biol Chem. 2004 Jun 11;279(24):25511-6. Epub 2004 Mar 30.


Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

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