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Items: 1 to 20 of 68


Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.

Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D.

Peptides. 2010 Dec;31(12):2289-93. doi: 10.1016/j.peptides.2010.09.015. Epub 2010 Oct 1.


Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM.

Structure. 2010 Sep 8;18(9):1083-93. doi: 10.1016/j.str.2010.05.014.


Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity.

Chen Q, Pinon DI, Miller LJ, Dong M.

J Biol Chem. 2010 Aug 6;285(32):24508-18. doi: 10.1074/jbc.M110.135749. Epub 2010 Jun 7.


Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2010 Mar 26;285(13):9919-31. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25.


Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor.

Koth CM, Abdul-Manan N, Lepre CA, Connolly PJ, Yoo S, Mohanty AK, Lippke JA, Zwahlen J, Coll JT, Doran JD, Garcia-Guzman M, Moore JM.

Biochemistry. 2010 Mar 9;49(9):1862-72. doi: 10.1021/bi901848m.


Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.

Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S.

J Biol Chem. 2010 Jan 1;285(1):723-30. doi: 10.1074/jbc.M109.033829. Epub 2009 Oct 27.


Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes.

Chen Q, Pinon DI, Miller LJ, Dong M.

J Biol Chem. 2009 Dec 4;284(49):34135-44. doi: 10.1074/jbc.M109.038109. Epub 2009 Oct 8.


Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

Michino M, Abola E; GPCR Dock 2008 participants, Brooks CL 3rd, Dixon JS, Moult J, Stevens RC.

Nat Rev Drug Discov. 2009 Jun;8(6):455-63. doi: 10.1038/nrd2877. Review.


Juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in small-molecule agonist action.

Dong M, Cox RF, Miller LJ.

J Biol Chem. 2009 Aug 14;284(33):21839-47. doi: 10.1074/jbc.M109.011924. Epub 2009 May 15.


Molecular modeling of the three-dimensional structure of GLP-1R and its interactions with several agonists.

Lin F, Wang R.

J Mol Model. 2009 Jan;15(1):53-65. doi: 10.1007/s00894-008-0372-2. Epub 2008 Oct 22.


Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.

Pioszak AA, Parker NR, Suino-Powell K, Xu HE.

J Biol Chem. 2008 Nov 21;283(47):32900-12. doi: 10.1074/jbc.M805749200. Epub 2008 Sep 17.


The N-terminal parts of VIP and antagonist PG97-269 physically interact with different regions of the human VPAC1 receptor.

Ceraudo E, Tan YV, Nicole P, Couvineau A, Laburthe M.

J Mol Neurosci. 2008 Nov;36(1-3):245-8. doi: 10.1007/s12031-008-9073-7. Epub 2008 Jul 3.


Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.

Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2008 Aug;74(2):413-22. doi: 10.1124/mol.108.047209. Epub 2008 May 8.


Molecular recognition of parathyroid hormone by its G protein-coupled receptor.

Pioszak AA, Xu HE.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5034-9. doi: 10.1073/pnas.0801027105. Epub 2008 Mar 28.


Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors.

Dong M, Gao F, Pinon DI, Miller LJ.

Mol Endocrinol. 2008 Jun;22(6):1489-99. doi: 10.1210/me.2008-0025. Epub 2008 Mar 27.


Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R.

J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20.


Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghänel J, Rahfeld JU, Demuth HU, Stubbs MT.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. Epub 2007 Aug 21.


Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2007 Aug;72(2):280-90. Epub 2007 May 2.


Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

Sun C, Song D, Davis-Taber RA, Barrett LW, Scott VE, Richardson PL, Pereda-Lopez A, Uchic ME, Solomon LR, Lake MR, Walter KA, Hajduk PJ, Olejniczak ET.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7875-80. Epub 2007 Apr 30.

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