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Items: 1 to 20 of 65

1.

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA.

Cell. 2010 Jun 25;141(7):1146-58. doi: 10.1016/j.cell.2010.05.008. Epub 2010 Jun 10.

2.

Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.

Koike MA, Green KN, Blurton-Jones M, Laferla FM.

Am J Pathol. 2010 Jul;177(1):300-10. doi: 10.2353/ajpath.2010.090750. Epub 2010 May 14.

3.

Autophagy impairment stimulates PS1 expression and gamma-secretase activity.

Ohta K, Mizuno A, Ueda M, Li S, Suzuki Y, Hida Y, Hayakawa-Yano Y, Itoh M, Ohta E, Kobori M, Nakagawa T.

Autophagy. 2010 Apr;6(3):345-52. Epub 2010 Apr 11.

PMID:
20168091
4.

mTOR regulation of autophagy.

Jung CH, Ro SH, Cao J, Otto NM, Kim DH.

FEBS Lett. 2010 Apr 2;584(7):1287-95. doi: 10.1016/j.febslet.2010.01.017. Epub 2010 Jan 18. Review.

5.

Regulation of autophagy by phosphatidylinositol 3-phosphate.

Burman C, Ktistakis NT.

FEBS Lett. 2010 Apr 2;584(7):1302-12. doi: 10.1016/j.febslet.2010.01.011. Epub 2010 Jan 13. Review.

6.

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems.

Korolchuk VI, Menzies FM, Rubinsztein DC.

FEBS Lett. 2010 Apr 2;584(7):1393-8. doi: 10.1016/j.febslet.2009.12.047. Epub 2009 Dec 28. Review.

7.

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.

Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E.

J Neurosci. 2009 Oct 28;29(43):13578-88. doi: 10.1523/JNEUROSCI.4390-09.2009.

8.

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.

Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B.

Nat Cell Biol. 2009 Nov;11(11):1340-6. doi: 10.1038/ncb1978. Epub 2009 Oct 18.

PMID:
19838174
9.

Autophagy, immunity, and microbial adaptations.

Deretic V, Levine B.

Cell Host Microbe. 2009 Jun 18;5(6):527-49. doi: 10.1016/j.chom.2009.05.016. Review.

10.

Regulation of the aging process by autophagy.

Salminen A, Kaarniranta K.

Trends Mol Med. 2009 May;15(5):217-24. doi: 10.1016/j.molmed.2009.03.004. Epub 2009 Apr 18. Review.

PMID:
19380253
11.

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells.

Yan Y, Flinn RJ, Wu H, Schnur RS, Backer JM.

Biochem J. 2009 Feb 1;417(3):747-55. doi: 10.1042/BJ20081865.

12.

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

Itakura E, Kishi C, Inoue K, Mizushima N.

Mol Biol Cell. 2008 Dec;19(12):5360-72. doi: 10.1091/mbc.E08-01-0080. Epub 2008 Oct 8.

13.

Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

Klionsky DJ, Elazar Z, Seglen PO, Rubinsztein DC.

Autophagy. 2008 Oct;4(7):849-50. Epub 2008 Oct 22.

PMID:
18758232
14.

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.

Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC.

Cell Death Differ. 2009 Jan;16(1):46-56. doi: 10.1038/cdd.2008.110. Epub 2008 Jul 18. Review.

15.

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.

Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM.

J Cell Biol. 2008 Jun 30;181(7):1107-16. doi: 10.1083/jcb.200706171.

16.

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T.

J Clin Invest. 2008 Jun;118(6):2190-9. doi: 10.1172/JCI33585.

17.

The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates.

Lindmo K, Brech A, Finley KD, Gaumer S, Contamine D, Rusten TE, Stenmark H.

Autophagy. 2008 May;4(4):500-6. Epub 2008 Mar 3.

PMID:
18326940
18.

Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia.

Bernardi L, Tomaino C, Anfossi M, Gallo M, Geracitano S, Costanzo A, Colao R, Puccio G, Frangipane F, Curcio SA, Mirabelli M, Smirne N, Iapaolo D, Maletta RG, Bruni AC.

Neurobiol Aging. 2009 Nov;30(11):1825-33. doi: 10.1016/j.neurobiolaging.2008.01.005. Epub 2008 Mar 7.

PMID:
18314228
19.

Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse.

Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP.

J Neurosci Res. 2008 May 15;86(7):1615-25. doi: 10.1002/jnr.21601.

PMID:
18189321
20.

Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling.

Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK.

J Neurosci. 2008 Jan 9;28(2):483-90. doi: 10.1523/JNEUROSCI.4067-07.2008.

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