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Items: 14


Bioprocessing of baculovirus vectors: a review.

Aucoin MG, Mena JA, Kamen AA.

Curr Gene Ther. 2010 Jun;10(3):174-86. Review.


Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial.

Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, Hauck B, Zelenaia O, Zhu X, Raffini L, Coppieters F, De Baere E, Shindler KS, Volpe NJ, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J.

Lancet. 2009 Nov 7;374(9701):1597-605. doi: 10.1016/S0140-6736(09)61836-5. Epub 2009 Oct 23. Erratum in: Lancet. 2010 Jan 2;375(9708):30.


A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells.

Smith RH, Levy JR, Kotin RM.

Mol Ther. 2009 Nov;17(11):1888-96. doi: 10.1038/mt.2009.128. Epub 2009 Jun 16.


AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells.

Mingozzi F, Meulenberg JJ, Hui DJ, Basner-Tschakarjan E, Hasbrouck NC, Edmonson SA, Hutnick NA, Betts MR, Kastelein JJ, Stroes ES, High KA.

Blood. 2009 Sep 3;114(10):2077-86. doi: 10.1182/blood-2008-07-167510. Epub 2009 Jun 8.


The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus.

Wasilko DJ, Lee SE, Stutzman-Engwall KJ, Reitz BA, Emmons TL, Mathis KJ, Bienkowski MJ, Tomasselli AG, Fischer HD.

Protein Expr Purif. 2009 Jun;65(2):122-32. doi: 10.1016/j.pep.2009.01.002. Epub 2009 Jan 11.


Safety and efficacy of gene transfer for Leber's congenital amaurosis.

Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, Sun J, Jacobs J, Dell'Osso L, Hertle R, Ma JX, Redmond TM, Zhu X, Hauck B, Zelenaia O, Shindler KS, Maguire MG, Wright JF, Volpe NJ, McDonnell JW, Auricchio A, High KA, Bennett J.

N Engl J Med. 2008 May 22;358(21):2240-8. doi: 10.1056/NEJMoa0802315. Epub 2008 Apr 27.


Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer.

Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J.

Mol Ther. 2008 Mar;16(3):458-65. doi: 10.1038/ Epub 2008 Jan 22.


Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system.

Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM.

J Gene Med. 2007 Nov;9(11):938-48.


Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy.

Negrete A, Esteban G, Kotin RM.

Appl Microbiol Biotechnol. 2007 Sep;76(4):761-72. Epub 2007 Aug 7.


Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales.

Negrete A, Kotin RM.

J Virol Methods. 2007 Nov;145(2):155-61. Epub 2007 Jul 2.


Stability of serum-free and purified baculovirus stocks under various storage conditions.

Jorio H, Tran R, Kamen A.

Biotechnol Prog. 2006 Jan-Feb;22(1):319-25.


Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Urabe M, Ding C, Kotin RM.

Hum Gene Ther. 2002 Nov 1;13(16):1935-43.


Long-term stability of baculoviruses stored under various conditions.

Jarvis DL, Garcia A Jr.

Biotechniques. 1994 Mar;16(3):508-13.


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