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Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.

Austin SA, Santhanam AV, Katusic ZS.

Circ Res. 2010 Dec 10;107(12):1498-502. doi: 10.1161/CIRCRESAHA.110.233080. Epub 2010 Dec 2.


NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration.

Kwak YD, Ma T, Diao S, Zhang X, Chen Y, Hsu J, Lipton SA, Masliah E, Xu H, Liao FF.

Mol Neurodegener. 2010 Nov 10;5:49. doi: 10.1186/1750-1326-5-49.


SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.

Gong B, Chen F, Pan Y, Arrieta-Cruz I, Yoshida Y, Haroutunian V, Pasinetti GM.

Aging Cell. 2010 Dec;9(6):1018-31. doi: 10.1111/j.1474-9726.2010.00632.x. Epub 2010 Oct 29.


The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.

Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H, Zhang YW.

Hum Mol Genet. 2010 Oct 1;19(19):3835-43. doi: 10.1093/hmg/ddq302. Epub 2010 Jul 22.


MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study.

Nelson PT, Wang WX.

J Alzheimers Dis. 2010;21(1):75-9. doi: 10.3233/JAD-2010-091603.


Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases.

Gu Z, Nakamura T, Lipton SA.

Mol Neurobiol. 2010 Jun;41(2-3):55-72. doi: 10.1007/s12035-010-8113-9. Epub 2010 Mar 25. Review.


Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.

Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW Jr, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, Nakamura M, Nunomura A, Perry G.

J Alzheimers Dis. 2010;19(1):363-72. doi: 10.3233/JAD-2010-1239. Review.


Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

Ma T, Zhao Y, Kwak YD, Yang Z, Thompson R, Luo Z, Xu H, Liao FF.

J Neurosci. 2009 Sep 9;29(36):11226-36. doi: 10.1523/JNEUROSCI.6150-08.2009.


Protein S-nitrosylation in health and disease: a current perspective.

Foster MW, Hess DT, Stamler JS.

Trends Mol Med. 2009 Sep;15(9):391-404. doi: 10.1016/j.molmed.2009.06.007. Epub 2009 Aug 31. Review.


Nitric oxide in cell survival: a janus molecule.

Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA.

Antioxid Redox Signal. 2009 Nov;11(11):2717-39. doi: 10.1089/ARS.2009.2721. Review.


Oxidative stress in diabetes and Alzheimer's disease.

Reddy VP, Zhu X, Perry G, Smith MA.

J Alzheimers Dis. 2009;16(4):763-74. doi: 10.3233/JAD-2009-1013. Review.


Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis.

Sultana R, Perluigi M, Butterfield DA.

Acta Neuropathol. 2009 Jul;118(1):131-50. doi: 10.1007/s00401-009-0517-0. Epub 2009 Mar 14. Review.


PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia.

Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, Pasinetti GM.

Arch Neurol. 2009 Mar;66(3):352-61. doi: 10.1001/archneurol.2008.588.


Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

Chen Y, Zhou K, Wang R, Liu Y, Kwak YD, Ma T, Thompson RC, Zhao Y, Smith L, Gasparini L, Luo Z, Xu H, Liao FF.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3907-12. doi: 10.1073/pnas.0807991106. Epub 2009 Feb 23.


The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.

Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M.

J Neurochem. 2009 Feb;108(4):1045-56. doi: 10.1111/j.1471-4159.2008.05858.x.


Cell death: protein misfolding and neurodegenerative diseases.

Nakamura T, Lipton SA.

Apoptosis. 2009 Apr;14(4):455-68. doi: 10.1007/s10495-008-0301-y. Review.


Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G.

J Biol Chem. 2009 Feb 6;284(6):3793-803. doi: 10.1074/jbc.M808920200. Epub 2008 Dec 12.


Cardiovascular risk factors and incident Alzheimer disease: a systematic review of the literature.

Purnell C, Gao S, Callahan CM, Hendrie HC.

Alzheimer Dis Assoc Disord. 2009 Jan-Mar;23(1):1-10. doi: 10.1097/WAD.0b013e318187541c. Review.


Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease.

Chen L, Na R, Gu M, Richardson A, Ran Q.

J Neurochem. 2008 Oct;107(1):197-207. doi: 10.1111/j.1471-4159.2008.05603.x. Epub 2008 Aug 2.


Vascular risk factors and Alzheimer's disease.

Cechetto DF, Hachinski V, Whitehead SN.

Expert Rev Neurother. 2008 May;8(5):743-50. doi: 10.1586/14737175.8.5.743. Review.


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