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Items: 1 to 20 of 241

1.

The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase.

Blair CR, Stone JB, Wells RG.

Biochim Biophys Acta. 2011 Feb;1813(2):332-9. doi: 10.1016/j.bbamcr.2010.12.005. Epub 2010 Dec 15.

2.

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL.

Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018.

3.

Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme.

Rajagopal C, Stone KL, Mains RE, Eipper BA.

J Biol Chem. 2010 Nov 5;285(45):34632-42. doi: 10.1074/jbc.M110.145334. Epub 2010 Sep 3.

4.

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

Ceni C, Kommaddi RP, Thomas R, Vereker E, Liu X, McPherson PS, Ritter B, Barker PA.

J Cell Sci. 2010 Jul 1;123(Pt 13):2299-307. doi: 10.1242/jcs.062612. Epub 2010 Jun 8.

5.
6.

Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

Seki M, Watanabe A, Enomoto S, Kawamura T, Ito H, Kodama T, Hamakubo T, Aburatani H.

FEBS Lett. 2010 Jul 2;584(13):2909-15. doi: 10.1016/j.febslet.2010.05.009. Epub 2010 May 13.

7.

Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.

Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ.

J Biol Chem. 2010 Apr 9;285(15):11378-91. doi: 10.1074/jbc.M109.088815. Epub 2010 Feb 9.

8.

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

Zhao G, Liu Z, Ilagan MX, Kopan R.

J Neurosci. 2010 Feb 3;30(5):1648-56. doi: 10.1523/JNEUROSCI.3826-09.2010.

9.

Alzheimer's disease.

Querfurth HW, LaFerla FM.

N Engl J Med. 2010 Jan 28;362(4):329-44. doi: 10.1056/NEJMra0909142. Review. No abstract available. Erratum in: N Engl J Med. 2011 Feb 10;364(6):588.

PMID:
20107219
10.

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.

Strisovsky K, Sharpe HJ, Freeman M.

Mol Cell. 2009 Dec 25;36(6):1048-59. doi: 10.1016/j.molcel.2009.11.006.

11.

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.

Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J.

Biochim Biophys Acta. 2010 Feb;1803(2):234-45. doi: 10.1016/j.bbamcr.2009.12.001. Epub 2009 Dec 21.

12.

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18367-72. doi: 10.1073/pnas.0907652106. Epub 2009 Oct 16.

13.

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.

Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U.

J Cell Sci. 2009 Oct 15;122(Pt 20):3703-14. doi: 10.1242/jcs.048090. Epub 2009 Sep 22.

14.

Klotho is a substrate for alpha-, beta- and gamma-secretase.

Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, Kaether C.

FEBS Lett. 2009 Oct 6;583(19):3221-4. doi: 10.1016/j.febslet.2009.09.009. Epub 2009 Sep 6.

15.

Glu-333 of nicastrin directly participates in gamma-secretase activity.

Dries DR, Shah S, Han YH, Yu C, Yu S, Shearman MS, Yu G.

J Biol Chem. 2009 Oct 23;284(43):29714-24. doi: 10.1074/jbc.M109.038737. Epub 2009 Sep 3.

16.

MUC1 is a substrate for gamma-secretase.

Julian J, Dharmaraj N, Carson DD.

J Cell Biochem. 2009 Nov 1;108(4):802-15. doi: 10.1002/jcb.22292.

17.

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.

Huysseune S, Kienlen-Campard P, Hébert S, Tasiaux B, Leroy K, Devuyst O, Brion JP, De Strooper B, Octave JN.

FASEB J. 2009 Dec;23(12):4158-67. doi: 10.1096/fj.09-140012. Epub 2009 Aug 17.

PMID:
19687153
18.

Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studies.

Hiltunen M, van Groen T, Jolkkonen J.

J Alzheimers Dis. 2009;18(2):401-12. doi: 10.3233/JAD-2009-1154. Review.

PMID:
19584429
19.

Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.

Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW.

J Neurosci. 2009 Jun 10;29(23):7459-73. doi: 10.1523/JNEUROSCI.4872-08.2009.

20.

Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation.

Inoue E, Deguchi-Tawarada M, Togawa A, Matsui C, Arita K, Katahira-Tayama S, Sato T, Yamauchi E, Oda Y, Takai Y.

J Cell Biol. 2009 May 4;185(3):551-64. doi: 10.1083/jcb.200809151.

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