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Items: 1 to 20 of 33

1.

The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy.

Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, Zong WX.

J Cell Biol. 2010 Nov 15;191(4):827-43. doi: 10.1083/jcb.201006056. Epub 2010 Nov 8.

2.

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.

Dbouk HA, Pang H, Fiser A, Backer JM.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19897-902. doi: 10.1073/pnas.1008739107. Epub 2010 Oct 28.

3.

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Sun M, Hillmann P, Hofmann BT, Hart JR, Vogt PK.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52. doi: 10.1073/pnas.1009652107. Epub 2010 Aug 16.

4.

Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer.

Ilić N, Roberts TM.

Curr Top Microbiol Immunol. 2010;347:55-77. doi: 10.1007/82_2010_63. Review.

PMID:
20517719
5.

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.

Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD, Anderson DH.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5471-6. doi: 10.1073/pnas.0908899107. Epub 2010 Mar 8.

6.

The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells.

Hill KM, Kalifa S, Das JR, Bhatti T, Gay M, Williams D, Taliferro-Smith L, De Marzo AM.

Prostate. 2010 May 15;70(7):755-64. doi: 10.1002/pros.21108.

PMID:
20058239
7.

Integrins in cancer: biological implications and therapeutic opportunities.

Desgrosellier JS, Cheresh DA.

Nat Rev Cancer. 2010 Jan;10(1):9-22. doi: 10.1038/nrc2748. Review.

8.

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells.

Ezratty EJ, Bertaux C, Marcantonio EE, Gundersen GG.

J Cell Biol. 2009 Nov 30;187(5):733-47. doi: 10.1083/jcb.200904054.

9.

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

Schoenwaelder SM, Ono A, Nesbitt WS, Lim J, Jarman K, Jackson SP.

J Biol Chem. 2010 Jan 22;285(4):2886-96. doi: 10.1074/jbc.M109.029132. Epub 2009 Nov 23.

10.

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.

Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13.

11.

p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA, Sellers WR.

Mol Cell Biol. 2009 Oct;29(19):5377-88. doi: 10.1128/MCB.01649-08. Epub 2009 Jul 27.

12.

Targeting PI3K signalling in cancer: opportunities, challenges and limitations.

Engelman JA.

Nat Rev Cancer. 2009 Aug;9(8):550-62. doi: 10.1038/nrc2664. Review.

PMID:
19629070
13.

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

Canobbio I, Stefanini L, Cipolla L, Ciraolo E, Gruppi C, Balduini C, Hirsch E, Torti M.

Blood. 2009 Sep 3;114(10):2193-6. doi: 10.1182/blood-2009-03-208074. Epub 2009 Jun 10.

14.

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E.

Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577.

15.

PTEN-deficient cancers depend on PIK3CB.

Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F, Yao YM, Lengauer C.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62. doi: 10.1073/pnas.0802655105. Epub 2008 Aug 28.

16.

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.

Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ.

Nature. 2008 Aug 7;454(7205):776-9. doi: 10.1038/nature07091. Epub 2008 Jun 25. Erratum in: Nature. 2016 May 12;533(7602):278.

17.

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. doi: 10.1073/pnas.0707761105. Epub 2008 Jun 10.

18.

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.

Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM.

Science. 2007 Dec 14;318(5857):1744-8.

19.

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL.

Science. 2007 Jul 13;317(5835):239-42.

20.

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7809-14. Epub 2007 Apr 30.

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