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Items: 1 to 20 of 46

1.

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.

O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM.

J Neurosci. 2010 Oct 27;30(43):14411-9. doi: 10.1523/JNEUROSCI.3537-10.2010.

2.

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.

Sandberg A, Luheshi LM, Söllvander S, Pereira de Barros T, Macao B, Knowles TP, Biverstål H, Lendel C, Ekholm-Petterson F, Dubnovitsky A, Lannfelt L, Dobson CM, Härd T.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15595-600. doi: 10.1073/pnas.1001740107. Epub 2010 Aug 16.

3.

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.

Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT.

Nat Chem. 2009 Jul;1(4):326-31. doi: 10.1038/nchem.247.

4.

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease.

Perrin RJ, Fagan AM, Holtzman DM.

Nature. 2009 Oct 15;461(7266):916-22. doi: 10.1038/nature08538. Review.

5.

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, Akioka M, Kikuchi S, Sato M, Ideno S, Noda M, Fukunari A, Muramatsu S, Itokazu Y, Sato K, Takahashi H, Teplow DB, Nabeshima Y, Kakita A, Imahori K, Hoshi M.

J Biol Chem. 2009 Nov 20;284(47):32895-905. doi: 10.1074/jbc.M109.000208. Epub 2009 Sep 15.

6.

Structure-neurotoxicity relationships of amyloid beta-protein oligomers.

Ono K, Condron MM, Teplow DB.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14745-50. doi: 10.1073/pnas.0905127106. Epub 2009 Aug 12.

7.

Amyloid formation by globular proteins under native conditions.

Chiti F, Dobson CM.

Nat Chem Biol. 2009 Jan;5(1):15-22. doi: 10.1038/nchembio.131. Review.

PMID:
19088715
8.

Amyloid beta-protein assembly and Alzheimer disease.

Roychaudhuri R, Yang M, Hoshi MM, Teplow DB.

J Biol Chem. 2009 Feb 20;284(8):4749-53. doi: 10.1074/jbc.R800036200. Epub 2008 Oct 9. Review. No abstract available.

9.

Structural classification of toxic amyloid oligomers.

Glabe CG.

J Biol Chem. 2008 Oct 31;283(44):29639-43. doi: 10.1074/jbc.R800016200. Epub 2008 Aug 22. Review.

10.

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ.

Nat Med. 2008 Aug;14(8):837-42. doi: 10.1038/nm1782. Epub 2008 Jun 22.

11.

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

Chimon S, Shaibat MA, Jones CR, Calero DC, Aizezi B, Ishii Y.

Nat Struct Mol Biol. 2007 Dec;14(12):1157-64.

PMID:
18059284
12.

Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, Teplow DB.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16522-7. Epub 2007 Oct 10.

13.

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.

Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL.

J Neurosci. 2007 Mar 14;27(11):2866-75.

14.

A beta oligomers - a decade of discovery.

Walsh DM, Selkoe DJ.

J Neurochem. 2007 Jun;101(5):1172-84. Epub 2007 Feb 5. Review.

15.

Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.

Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL.

J Neurosci. 2007 Jan 24;27(4):796-807.

16.

Solution state characterization of amyloid beta-derived diffusible ligands.

Hepler RW, Grimm KM, Nahas DD, Breese R, Dodson EC, Acton P, Keller PM, Yeager M, Wang H, Shughrue P, Kinney G, Joyce JG.

Biochemistry. 2006 Dec 26;45(51):15157-67. Epub 2006 Dec 6.

PMID:
17176037
17.

A century-old debate on protein aggregation and neurodegeneration enters the clinic.

Lansbury PT, Lashuel HA.

Nature. 2006 Oct 19;443(7113):774-9. Review.

PMID:
17051203
19.

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

Deshpande A, Mina E, Glabe C, Busciglio J.

J Neurosci. 2006 May 31;26(22):6011-8.

20.

A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.

PMID:
16541076

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