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Items: 1 to 20 of 27

1.

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.

Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG.

Biochimie. 2011 Mar;93(3):570-82. doi: 10.1016/j.biochi.2010.11.015. Epub 2010 Dec 7.

2.

A mechanism for functional segregation of mitochondrial and cytosolic genetic codes.

Español Y, Thut D, Schneider A, Ribas de Pouplana L.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19420-5. doi: 10.1073/pnas.0909937106. Epub 2009 Oct 30.

3.

Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.

Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC.

J Biomol Screen. 2009 Jul;14(6):700-7. doi: 10.1177/1087057109335749. Epub 2009 May 21.

4.

Dual targeting of a tRNAAsp requires two different aspartyl-tRNA synthetases in Trypanosoma brucei.

Charrière F, O'Donoghue P, Helgadóttir S, Maréchal-Drouard L, Cristodero M, Horn EK, Söll D, Schneider A.

J Biol Chem. 2009 Jun 12;284(24):16210-7. doi: 10.1074/jbc.M109.005348. Epub 2009 Apr 22.

5.

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections.

Critchley IA, Green LS, Young CL, Bullard JM, Evans RJ, Price M, Jarvis TC, Guiles JW, Janjic N, Ochsner UA.

J Antimicrob Chemother. 2009 May;63(5):954-63. doi: 10.1093/jac/dkp041. Epub 2009 Mar 3.

PMID:
19258353
6.

Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.

Green LS, Bullard JM, Ribble W, Dean F, Ayers DF, Ochsner UA, Janjic N, Jarvis TC.

Antimicrob Agents Chemother. 2009 Jan;53(1):86-94. doi: 10.1128/AAC.00275-08. Epub 2008 Nov 17.

7.

New agents for Clostridium difficile-associated disease.

Guiles J, Critchley I, Sun X.

Expert Opin Investig Drugs. 2008 Nov;17(11):1671-83. doi: 10.1517/13543784.17.11.1671 . Review.

PMID:
18922104
8.

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC.

Antimicrob Agents Chemother. 2008 Oct;52(10):3710-7. doi: 10.1128/AAC.00364-08. Epub 2008 Jul 21.

9.

From one amino acid to another: tRNA-dependent amino acid biosynthesis.

Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Söll D.

Nucleic Acids Res. 2008 Apr;36(6):1813-25. doi: 10.1093/nar/gkn015. Epub 2008 Feb 5. Review.

10.

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.

Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH.

Antimicrob Agents Chemother. 2007 Oct;51(10):3659-71. Epub 2007 Jul 2.

11.

Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents.

Ochsner UA, Sun X, Jarvis T, Critchley I, Janjic N.

Expert Opin Investig Drugs. 2007 May;16(5):573-93. Review.

PMID:
17461733
12.

Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.

Mehlin C, Boni E, Buckner FS, Engel L, Feist T, Gelb MH, Haji L, Kim D, Liu C, Mueller N, Myler PJ, Reddy JT, Sampson JN, Subramanian E, Van Voorhis WC, Worthey E, Zucker F, Hol WG.

Mol Biochem Parasitol. 2006 Aug;148(2):144-60. Epub 2006 Apr 18.

PMID:
16644028
13.

Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei.

Charrière F, Helgadóttir S, Horn EK, Söll D, Schneider A.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6847-52. Epub 2006 Apr 24.

14.

Antibacterial activity of REP8839, a new antibiotic for topical use.

Critchley IA, Young CL, Stone KC, Ochsner UA, Guiles J, Tarasow T, Janjic N.

Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52.

15.

A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei.

Alibu VP, Storm L, Haile S, Clayton C, Horn D.

Mol Biochem Parasitol. 2005 Jan;139(1):75-82.

PMID:
15610821
16.

Non-canonical eukaryotic glutaminyl- and glutamyl-tRNA synthetases form mitochondrial aminoacyl-tRNA in Trypanosoma brucei.

Rinehart J, Horn EK, Wei D, Soll D, Schneider A.

J Biol Chem. 2004 Jan 9;279(2):1161-6. Epub 2003 Oct 16.

17.

Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.

Kroe RR, Regan J, Proto A, Peet GW, Roy T, Landro LD, Fuschetto NG, Pargellis CA, Ingraham RH.

J Med Chem. 2003 Oct 23;46(22):4669-75.

PMID:
14561086
18.

Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ.

Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9.

19.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8.

PMID:
12639554
20.

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF.

Mol Biochem Parasitol. 2003 Feb;126(2):155-63. Review.

PMID:
12615314

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