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Items: 1 to 20 of 59


Calcium/NFAT signalling promotes early nephrogenesis.

Burn SF, Webb A, Berry RL, Davies JA, Ferrer-Vaquer A, Hadjantonakis AK, Hastie ND, Hohenstein P.

Dev Biol. 2011 Apr 15;352(2):288-98. doi: 10.1016/j.ydbio.2011.01.033.


A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.

Ewan K, Pajak B, Stubbs M, Todd H, Barbeau O, Quevedo C, Botfield H, Young R, Ruddle R, Samuel L, Battersby A, Raynaud F, Allen N, Wilson S, Latinkic B, Workman P, McDonald E, Blagg J, Aherne W, Dale T.

Cancer Res. 2010 Jul 15;70(14):5963-73. doi: 10.1158/0008-5472.CAN-10-1028.


Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.

Chen W, Chen M, Barak LS.

Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G293-300. doi: 10.1152/ajpgi.00005.2010. Review.


Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.

Nature. 2009 Oct 1;461(7264):614-20. doi: 10.1038/nature08356.


The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.

Mo R, Chew TL, Maher MT, Bellipanni G, Weinberg ES, Gottardi CJ.

J Biol Chem. 2009 Oct 9;284(41):28222-31. doi: 10.1074/jbc.M109.045039.


Nuclear signalling by tumour-associated antigen EpCAM.

Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, Kieu C, Papior P, Baeuerle PA, Munz M, Gires O.

Nat Cell Biol. 2009 Feb;11(2):162-71. doi: 10.1038/ncb1824.


Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L.

Nat Chem Biol. 2009 Feb;5(2):100-7. doi: 10.1038/nchembio.137.


Crystal structure of a full-length beta-catenin.

Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W.

Structure. 2008 Mar;16(3):478-87. doi: 10.1016/j.str.2007.12.021.


Whole-mount in situ hybridization and detection of RNAs in vertebrate embryos and isolated organs.

Pizard A, Haramis A, Carrasco AE, Franco P, López S, Paganelli A.

Curr Protoc Mol Biol. 2004 May;Chapter 14:Unit 14.9. doi: 10.1002/0471142727.mb1409s66.


The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors.

Medyouf H, Ghysdael J.

Cell Cycle. 2008 Feb 1;7(3):297-303. Review.


Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target.

Timofeeva OA, Gaponenko V, Lockett SJ, Tarasov SG, Jiang S, Michejda CJ, Perantoni AO, Tarasova NI.

ACS Chem Biol. 2007 Dec 21;2(12):799-809.


beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors.

Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch J.

Development. 2007 Sep;134(17):3177-90.


Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth.

Remsberg JR, Lou H, Tarasov SG, Dean M, Tarasova NI.

J Med Chem. 2007 Sep 6;50(18):4534-8.


Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.

Park JS, Valerius MT, McMahon AP.

Development. 2007 Jul;134(13):2533-9.


Canonical WNT signaling during kidney development.

Iglesias DM, Hueber PA, Chu L, Campbell R, Patenaude AM, Dziarmaga AJ, Quinlan J, Mohamed O, Dufort D, Goodyer PR.

Am J Physiol Renal Physiol. 2007 Aug;293(2):F494-500.


Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.

Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS.

BMC Biol. 2007 Apr 10;5:15.


Transgenic Wnt/TCF pathway reporters: all you need is Lef?

Barolo S.

Oncogene. 2006 Dec 4;25(57):7505-11. Review.


Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures.

Alcalay NI, Brantley JG, Sharma M, Gooch JL, Vanden Heuvel GB.

Dev Dyn. 2007 Jan;236(1):184-91.


The cellular basis of kidney development.

Dressler GR.

Annu Rev Cell Dev Biol. 2006;22:509-29. Review.


Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling.

Gao Y, Wang HY.

J Biol Chem. 2006 Jul 7;281(27):18394-400.

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