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Items: 1 to 20 of 68


Initiation and propagation of neurodegeneration.

Haass C.

Nat Med. 2010 Nov;16(11):1201-4. doi: 10.1038/nm.2223. Epub 2010 Sep 21.


Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.

Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS.

JAMA. 2010 Nov 3;304(17):1903-11. doi: 10.1001/jama.2010.1510.


The genetics of Alzheimer disease: back to the future.

Bertram L, Lill CM, Tanzi RE.

Neuron. 2010 Oct 21;68(2):270-81. doi: 10.1016/j.neuron.2010.10.013. Review.


Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease.

Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D.

PLoS One. 2010 Sep 8;5(9):e12538. doi: 10.1371/journal.pone.0012538.


Fyn-tau-amyloid: a toxic triad.

Haass C, Mandelkow E.

Cell. 2010 Aug 6;142(3):356-8. doi: 10.1016/j.cell.2010.07.032.


Inflammation in neurodegenerative diseases.

Amor S, Puentes F, Baker D, van der Valk P.

Immunology. 2010 Feb;129(2):154-69. doi: 10.1111/j.1365-2567.2009.03225.x. Review.


The propagation of prion-like protein inclusions in neurodegenerative diseases.

Goedert M, Clavaguera F, Tolnay M.

Trends Neurosci. 2010 Jul;33(7):317-25. doi: 10.1016/j.tins.2010.04.003. Epub 2010 May 20. Review.


Biomarkers of oxidative damage and inflammation in Alzheimer's disease.

Galasko D, Montine TJ.

Biomark Med. 2010 Feb;4(1):27-36. doi: 10.2217/bmm.09.89. Review.


Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival.

Antony R, Lukiw WJ, Bazan NG.

J Biol Chem. 2010 Jun 11;285(24):18301-8. doi: 10.1074/jbc.M109.095232. Epub 2010 Apr 2.


PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.

Faghiri Z, Bazan NG.

Exp Eye Res. 2010 Jun;90(6):718-25. doi: 10.1016/j.exer.2010.03.002. Epub 2010 Mar 15.


Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1.

Calandria JM, Marcheselli VL, Mukherjee PK, Uddin J, Winkler JW, Petasis NA, Bazan NG.

J Biol Chem. 2009 Jun 26;284(26):17877-82. doi: 10.1074/jbc.M109.003988. Epub 2009 Apr 29.


Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association.

Fotuhi M, Mohassel P, Yaffe K.

Nat Clin Pract Neurol. 2009 Mar;5(3):140-52. doi: 10.1038/ncpneuro1044. Review.


Structural basis for the activation of PPARgamma by oxidized fatty acids.

Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW.

Nat Struct Mol Biol. 2008 Sep;15(9):924-31.


High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model.

Julien C, Tremblay C, Phivilay A, Berthiaume L, Emond V, Julien P, Calon F.

Neurobiol Aging. 2010 Sep;31(9):1516-31. doi: 10.1016/j.neurobiolaging.2008.08.022. Epub 2008 Oct 15.


An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells.

Lukiw WJ, Zhao Y, Cui JG.

J Biol Chem. 2008 Nov 14;283(46):31315-22. doi: 10.1074/jbc.M805371200. Epub 2008 Sep 18.


Fat and beyond: the diverse biology of PPARgamma.

Tontonoz P, Spiegelman BM.

Annu Rev Biochem. 2008;77:289-312. doi: 10.1146/annurev.biochem.77.061307.091829. Review.


Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD.

J Biol Chem. 2008 Jul 18;283(29):19927-35. doi: 10.1074/jbc.M803625200. Epub 2008 May 19.


Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention.

Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM.

J Neurosci. 2007 Dec 26;27(52):14299-307.

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