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Chromatin remodeling in the aging genome of Drosophila.

Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL.

Aging Cell. 2010 Dec;9(6):971-8. doi: 10.1111/j.1474-9726.2010.00624.x. Epub 2010 Oct 21.


Genome-wide distribution of macroH2A1 histone variants in mouse liver chromatin.

Changolkar LN, Singh G, Cui K, Berletch JB, Zhao K, Disteche CM, Pehrson JR.

Mol Cell Biol. 2010 Dec;30(23):5473-83. doi: 10.1128/MCB.00518-10. Epub 2010 Oct 11.


Epigenetic changes play critical role in age-associated dysfunctions of the liver.

Jin J, Wang GL, Iakova P, Shi X, Haefliger S, Finegold M, Timchenko NA.

Aging Cell. 2010 Oct;9(5):895-910. doi: 10.1111/j.1474-9726.2010.00617.x.


Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.

Kennedy AL, McBryan T, Enders GH, Johnson FB, Zhang R, Adams PD.

Cell Div. 2010 Jun 22;5:16. doi: 10.1186/1747-1028-5-16.


Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.

Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM.

Aging Cell. 2010 Jun;9(3):398-409. doi: 10.1111/j.1474-9726.2010.00567.x. Epub 2010 Mar 13.


Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.

Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, Beyan H, Whittaker P, McCann OT, Finer S, Valdes AM, Leslie RD, Deloukas P, Spector TD.

Genome Res. 2010 Apr;20(4):434-9. doi: 10.1101/gr.103101.109. Epub 2010 Mar 10.


Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, Savage DA, Mueller-Holzner E, Marth C, Kocjan G, Gayther SA, Jones A, Beck S, Wagner W, Laird PW, Jacobs IJ, Widschwendter M.

Genome Res. 2010 Apr;20(4):440-6. doi: 10.1101/gr.103606.109. Epub 2010 Mar 10.


Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences.

Jintaridth P, Mutirangura A.

Physiol Genomics. 2010 Apr 1;41(2):194-200. doi: 10.1152/physiolgenomics.00146.2009. Epub 2010 Feb 9.


DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells.

Bork S, Pfister S, Witt H, Horn P, Korn B, Ho AD, Wagner W.

Aging Cell. 2010 Feb;9(1):54-63. doi: 10.1111/j.1474-9726.2009.00535.x. Epub 2009 Nov 6.


The essential function of HP1 beta: a case of the tail wagging the dog?

Billur M, Bartunik HD, Singh PB.

Trends Biochem Sci. 2010 Feb;35(2):115-23. doi: 10.1016/j.tibs.2009.09.003. Review.


Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence.

Adams PD.

Mol Cell. 2009 Oct 9;36(1):2-14. doi: 10.1016/j.molcel.2009.09.021. Review.


Mechanisms of polycomb gene silencing: knowns and unknowns.

Simon JA, Kingston RE.

Nat Rev Mol Cell Biol. 2009 Oct;10(10):697-708. doi: 10.1038/nrm2763. Epub 2009 Sep 9. Review.


The role of epigenetics in aging and age-related diseases.

Calvanese V, Lara E, Kahn A, Fraga MF.

Ageing Res Rev. 2009 Oct;8(4):268-76. doi: 10.1016/j.arr.2009.03.004. Epub 2009 Apr 1. Review.


A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.

Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13.


DNA damage response and cellular senescence in tissues of aging mice.

Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T.

Aging Cell. 2009 Jun;8(3):311-23. doi: 10.1111/j.1474-9726.2009.00481.x. Epub 2009 Apr 9.


Decline in genomic DNA methylation through aging in a cohort of elderly subjects.

Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, Sparrow D, Vokonas P, Baccarelli A.

Mech Ageing Dev. 2009 Apr;130(4):234-9. doi: 10.1016/j.mad.2008.12.003. Epub 2008 Dec 27.


SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.

Cell. 2008 Nov 28;135(5):907-18. doi: 10.1016/j.cell.2008.10.025.


The heterochromatin protein 1 (HP1) family: put away a bias toward HP1.

Kwon SH, Workman JL.

Mol Cells. 2008 Sep 30;26(3):217-27. Epub 2008 Jul 30. Review.


Living on a break: cellular senescence as a DNA-damage response.

d'Adda di Fagagna F.

Nat Rev Cancer. 2008 Jul;8(7):512-22. doi: 10.1038/nrc2440. Review.


Aging by epigenetics--a consequence of chromatin damage?

Sedivy JM, Banumathy G, Adams PD.

Exp Cell Res. 2008 Jun 10;314(9):1909-17. doi: 10.1016/j.yexcr.2008.02.023. Epub 2008 Mar 12. Review.

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