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Items: 1 to 20 of 42

1.

IL-35-mediated induction of a potent regulatory T cell population.

Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, Finkelstein D, Forbes K, Workman CJ, Brown SA, Rehg JE, Jones ML, Ni HT, Artis D, Turk MJ, Vignali DA.

Nat Immunol. 2010 Dec;11(12):1093-101. doi: 10.1038/ni.1952. Epub 2010 Oct 17.

2.

The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling.

Crabé S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, Mavoungou-Bigouagou U, Lefouili F, Cognet I, Ferlin W, Elson G, Jeannin P, Gauchat JF.

J Immunol. 2009 Dec 15;183(12):7692-702. doi: 10.4049/jimmunol.0901464.

3.

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D; Western Regional Alliance for Pediatric IBD, Silber G, Wrobel I, Quiros A; International IBD Genetics Consortium, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H.

Nat Genet. 2009 Dec;41(12):1335-40. doi: 10.1038/ng.489. Epub 2009 Nov 15.

4.

IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis.

Troy AE, Zaph C, Du Y, Taylor BC, Guild KJ, Hunter CA, Saris CJ, Artis D.

J Immunol. 2009 Aug 1;183(3):2037-44. doi: 10.4049/jimmunol.0802918. Epub 2009 Jul 13.

5.

A protective function for interleukin 17A in T cell-mediated intestinal inflammation.

O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA.

Nat Immunol. 2009 Jun;10(6):603-9. doi: 10.1038/ni.1736.

6.

The interleukin-23 axis in intestinal inflammation.

Ahern PP, Izcue A, Maloy KJ, Powrie F.

Immunol Rev. 2008 Dec;226:147-59. doi: 10.1111/j.1600-065X.2008.00705.x. Review.

PMID:
19161422
7.

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.

Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA.

Immunity. 2008 Dec 19;29(6):947-57. doi: 10.1016/j.immuni.2008.11.003.

8.

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF.

Gastroenterology. 2009 Jan;136(1):257-67. doi: 10.1053/j.gastro.2008.10.018. Epub 2008 Oct 9.

PMID:
18992745
9.

Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t.

Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H.

Eur J Immunol. 2008 May;38(5):1204-14. doi: 10.1002/eji.200838145.

10.

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.

Izcue A, Hue S, Buonocore S, Arancibia-Cárcamo CV, Ahern PP, Iwakura Y, Maloy KJ, Powrie F.

Immunity. 2008 Apr;28(4):559-70. doi: 10.1016/j.immuni.2008.02.019.

11.

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.

Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, Joyce S, Hunter CA.

Int Immunol. 2008 Jun;20(6):739-52. doi: 10.1093/intimm/dxn032. Epub 2008 Mar 28.

PMID:
18375937
12.

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells.

Batten M, Kljavin NM, Li J, Walter MJ, de Sauvage FJ, Ghilardi N.

J Immunol. 2008 Mar 1;180(5):2752-6.

13.

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.

Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, Abbas AR, Modrusan Z, Ghilardi N, de Sauvage FJ, Ouyang W.

Nat Med. 2008 Mar;14(3):282-9. doi: 10.1038/nm1720. Epub 2008 Feb 10.

PMID:
18264109
14.

IL-27 induces a Th1 immune response and susceptibility to experimental arthritis.

Cao Y, Doodes PD, Glant TT, Finnegan A.

J Immunol. 2008 Jan 15;180(2):922-30.

15.

IL-27 inhibits the development of regulatory T cells via STAT3.

Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M.

Int Immunol. 2008 Feb;20(2):223-34. Epub 2007 Dec 21.

PMID:
18156621
16.

The inhibitory cytokine IL-35 contributes to regulatory T-cell function.

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA.

Nature. 2007 Nov 22;450(7169):566-9.

PMID:
18033300
17.

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.

Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O'Shea JJ, Hunter CA.

Nat Immunol. 2007 Dec;8(12):1363-71. Epub 2007 Nov 11.

PMID:
17994025
18.

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.

Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A.

Nat Immunol. 2007 Dec;8(12):1372-9. Epub 2007 Nov 11. Erratum in: Nat Immunol. 2008 Jan;9(1):105.

PMID:
17994023
19.

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL.

Nat Immunol. 2007 Dec;8(12):1380-9. Epub 2007 Nov 11.

PMID:
17994022
20.

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.

Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y.

J Exp Med. 2007 Aug 6;204(8):1775-85. Epub 2007 Jul 9.

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