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Items: 1 to 20 of 179


Structure of the human mTOR complex I and its implications for rapamycin inhibition.

Yip CK, Murata K, Walz T, Sabatini DM, Kang SA.

Mol Cell. 2010 Jun 11;38(5):768-74. doi: 10.1016/j.molcel.2010.05.017.


Termination of autophagy and reformation of lysosomes regulated by mTOR.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ.

Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.


A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.

Charest PG, Shen Z, Lakoduk A, Sasaki AT, Briggs SP, Firtel RA.

Dev Cell. 2010 May 18;18(5):737-49. doi: 10.1016/j.devcel.2010.03.017.


Extending healthy life span--from yeast to humans.

Fontana L, Partridge L, Longo VD.

Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539. Review.


Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.


Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.

Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D.

Cancer Cell. 2010 Mar 16;17(3):249-61. doi: 10.1016/j.ccr.2010.01.021.


Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.

Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L.

Cell Metab. 2010 Jan;11(1):35-46. doi: 10.1016/j.cmet.2009.11.010.


Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.

Janes MR, Limon JJ, So L, Chen J, Lim RJ, Chavez MA, Vu C, Lilly MB, Mallya S, Ong ST, Konopleva M, Martin MB, Ren P, Liu Y, Rommel C, Fruman DA.

Nat Med. 2010 Feb;16(2):205-13. doi: 10.1038/nm.2091. Epub 2010 Jan 13.


AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Chresta CM, Davies BR, Hickson I, Harding T, Cosulich S, Critchlow SE, Vincent JP, Ellston R, Jones D, Sini P, James D, Howard Z, Dudley P, Hughes G, Smith L, Maguire S, Hummersone M, Malagu K, Menear K, Jenkins R, Jacobsen M, Smith GC, Guichard S, Pass M.

Cancer Res. 2010 Jan 1;70(1):288-98. doi: 10.1158/0008-5472.CAN-09-1751. Epub 2009 Dec 22.


Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.

Brachmann SM, Hofmann I, Schnell C, Fritsch C, Wee S, Lane H, Wang S, Garcia-Echeverria C, Maira SM.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22299-304. doi: 10.1073/pnas.0905152106. Epub 2009 Dec 10.


Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.

Grandison RC, Piper MD, Partridge L.

Nature. 2009 Dec 24;462(7276):1061-4. doi: 10.1038/nature08619. Epub 2009 Dec 2.


mTOR and cancer: many loops in one pathway.

Efeyan A, Sabatini DM.

Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/ Epub 2009 Nov 27.


mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.

Chen C, Liu Y, Liu Y, Zheng P.

Sci Signal. 2009 Nov 24;2(98):ra75. doi: 10.1126/scisignal.2000559.


4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, Kapahi P.

Cell. 2009 Oct 2;139(1):149-60. doi: 10.1016/j.cell.2009.07.034.


Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.


The Vam6 GEF controls TORC1 by activating the EGO complex.

Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C.

Mol Cell. 2009 Sep 11;35(5):563-73. doi: 10.1016/j.molcel.2009.06.033.


mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS.

Cell Stem Cell. 2009 Sep 4;5(3):279-89. doi: 10.1016/j.stem.2009.06.017.


NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas.

Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, Yung WK.

Mol Cancer Ther. 2009 Aug;8(8):2204-10. doi: 10.1158/1535-7163.MCT-09-0160. Epub 2009 Aug 11.


Regulation mechanisms and signaling pathways of autophagy.

He C, Klionsky DJ.

Annu Rev Genet. 2009;43:67-93. doi: 10.1146/annurev-genet-102808-114910. Review.


Atg101, a novel mammalian autophagy protein interacting with Atg13.

Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N.

Autophagy. 2009 Oct;5(7):973-9. Epub 2009 Oct 18.


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