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Items: 1 to 20 of 71

1.

Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases.

Kinstrie R, Luebbering N, Miranda-Saavedra D, Sibbet G, Han J, Lochhead PA, Cleghon V.

Sci Signal. 2010 Mar 2;3(111):ra16. doi: 10.1126/scisignal.2000579.

2.

Kinase suppressor of Ras transphosphorylates c-Raf-1.

Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. doi: 10.1016/j.bbrc.2009.09.048. Epub 2009 Sep 17.

3.

A dimerization-dependent mechanism drives RAF catalytic activation.

Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M.

Nature. 2009 Sep 24;461(7263):542-5. doi: 10.1038/nature08314. Epub 2009 Sep 2.

PMID:
19727074
4.

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation.

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Physiol Biochem. 2009;24(3-4):219-30. doi: 10.1159/000233248. Epub 2009 Aug 3.

5.

KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs.

Lin J, Harding A, Giurisato E, Shaw AS.

Mol Cell Biol. 2009 Apr;29(8):2082-91. doi: 10.1128/MCB.01634-08. Epub 2009 Feb 2.

6.

ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death.

Cheng Y, Qiu F, Tashiro S, Onodera S, Ikejima T.

Biochem Biophys Res Commun. 2008 Nov 21;376(3):483-8. doi: 10.1016/j.bbrc.2008.09.018. Epub 2008 Sep 15.

PMID:
18796294
7.

Role of NF-kappaB and PI 3-kinase/Akt in TNF-alpha-induced cytotoxicity in microvascular endothelial cells.

Zhou Z, Gengaro P, Wang W, Wang XQ, Li C, Faubel S, Rivard C, Schrier RW.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F932-41. doi: 10.1152/ajprenal.00066.2008. Epub 2008 Jul 16.

8.

Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1.

McKay MM, Morrison DK.

J Biol Chem. 2007 Sep 7;282(36):26225-34. Epub 2007 Jul 5.

9.

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

Scholl FA, Dumesic PA, Barragan DI, Harada K, Bissonauth V, Charron J, Khavari PA.

Dev Cell. 2007 Apr;12(4):615-29.

10.

The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis.

Fusello AM, Mandik-Nayak L, Shih F, Lewis RE, Allen PM, Shaw AS.

J Immunol. 2006 Nov 1;177(9):6152-8.

11.

Emerging roles of pseudokinases.

Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR.

Trends Cell Biol. 2006 Sep;16(9):443-52. Epub 2006 Aug 1. Review.

PMID:
16879967
12.

Review article: Infliximab therapy for inflammatory bowel disease--seven years on.

Rutgeerts P, Van Assche G, Vermeire S.

Aliment Pharmacol Ther. 2006 Feb 15;23(4):451-63. Review.

14.

Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.

Yan F, John SK, Wilson G, Jones DS, Washington MK, Polk DB.

J Clin Invest. 2004 Nov;114(9):1272-80.

15.

The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.

Xing HR, Campodonico L, Kolesnick R.

J Biol Chem. 2004 Jun 18;279(25):26210-4. Epub 2004 Apr 13. Retraction in: J Biol Chem. 2013 Nov 22;288(47):34052.

16.

Exploiting features of adenovirus replication to support mammalian kinase production.

Cotten M, Stegmueller K, Eickhoff J, Hanke M, Herzberger K, Herget T, Choidas A, Daub H, Godl K.

Nucleic Acids Res. 2003 Nov 1;31(21):e128.

17.

Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms.

Corredor J, Yan F, Shen CC, Tong W, John SK, Wilson G, Whitehead R, Polk DB.

Am J Physiol Cell Physiol. 2003 Apr;284(4):C953-61. Epub 2002 Dec 4.

18.

Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway.

Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M, Patrick J, Steeg PS.

J Biol Chem. 2002 Aug 30;277(35):32389-99. Epub 2002 Jun 24.

19.

KSR is a scaffold required for activation of the ERK/MAPK module.

Roy F, Laberge G, Douziech M, Ferland-McCollough D, Therrien M.

Genes Dev. 2002 Feb 15;16(4):427-38.

20.

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.

Müller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK.

Mol Cell. 2001 Nov;8(5):983-93.

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