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Items: 1 to 20 of 49


Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice.

Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T.

Environ Health Perspect. 2010 Nov;118(11):1557-63. doi: 10.1289/ehp.1001928.


Toxicogenetics: population-based testing of drug and chemical safety in mouse models.

Rusyn I, Gatti DM, Wiltshire T, Kleeberger SR, Threadgill DW.

Pharmacogenomics. 2010 Aug;11(8):1127-36. doi: 10.2217/pgs.10.100. Review. Erratum in: Pharmacogenomics. 2010 Sep;11(9):1344. Wilshire, Timothy [corrected to Wiltshire, Timothy].


Use of transcriptomics in understanding mechanisms of drug-induced toxicity.

Cui Y, Paules RS.

Pharmacogenomics. 2010 Apr;11(4):573-85. doi: 10.2217/pgs.10.37. Review.


Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels.

Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B.

Aging Cell. 2009 Jun;8(3):277-87. doi: 10.1111/j.1474-9726.2009.00478.x. Epub 2009 Apr 9.


Replication and narrowing of gene expression quantitative trait loci using inbred mice.

Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I.

Mamm Genome. 2009 Jul;20(7):437-46. doi: 10.1007/s00335-009-9199-0. Epub 2009 Jul 17.


Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Kim S, Collins LB, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I.

Toxicology. 2009 Aug 21;262(3):230-8. doi: 10.1016/j.tox.2009.06.013. Epub 2009 Jun 21.


Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes.

Zambelli F, Pesole G, Pavesi G.

Nucleic Acids Res. 2009 Jul;37(Web Server issue):W247-52. doi: 10.1093/nar/gkp464. Epub 2009 May 31.


Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans.

Cooper GS, Makris SL, Nietert PJ, Jinot J.

Environ Health Perspect. 2009 May;117(5):696-702. doi: 10.1289/ehp.11782. Epub 2009 Jan 9. Review.


Trichloroethylene liver toxicity in mouse and rat: microarray analysis reveals species differences in gene expression.

Sano Y, Nakashima H, Yoshioka N, Etho N, Nomiyama T, Nishiwaki Y, Takebayashi T, Oame K.

Arch Toxicol. 2009 Sep;83(9):835-49. doi: 10.1007/s00204-009-0431-1. Epub 2009 May 16.


Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.

Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I.

Toxicol Sci. 2009 Jul;110(1):235-43. doi: 10.1093/toxsci/kfp096. Epub 2009 May 6.


Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B, Rusyn I.

Mutat Res. 2008 Sep 26;644(1-2):17-23. doi: 10.1016/j.mrfmmm.2008.06.009. Epub 2008 Jul 1.


Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1.

Ramdhan DH, Kamijima M, Yamada N, Ito Y, Yanagiba Y, Nakamura D, Okamura A, Ichihara G, Aoyama T, Gonzalez FJ, Nakajima T.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):300-7. doi: 10.1016/j.taap.2008.04.020. Epub 2008 May 2.


Kinetics of chloral hydrate and its metabolites in male human volunteers.

Merdink JL, Robison LM, Stevens DK, Hu M, Parker JC, Bull RJ.

Toxicology. 2008 Mar 12;245(1-2):130-40. doi: 10.1016/j.tox.2007.12.018. Epub 2007 Dec 28.


A sequence-based variation map of 8.27 million SNPs in inbred mouse strains.

Frazer KA, Eskin E, Kang HM, Bogue MA, Hinds DA, Beilharz EJ, Gupta RV, Montgomery J, Morenzoni MM, Nilsen GB, Pethiyagoda CL, Stuve LL, Johnson FM, Daly MJ, Wade CM, Cox DR.

Nature. 2007 Aug 30;448(7157):1050-3. Epub 2007 Jul 29.


Genome-level analysis of genetic regulation of liver gene expression networks.

Gatti D, Maki A, Chesler EJ, Kirova R, Kosyk O, Lu L, Manly KF, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I.

Hepatology. 2007 Aug;46(2):548-57.


The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.

Dongol B, Shah Y, Kim I, Gonzalez FJ, Hunt MC.

J Lipid Res. 2007 Aug;48(8):1781-91. Epub 2007 May 7.

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