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An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions.

Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA, Kirkley SA, Fialkow LB.

Transfusion. 2010 Dec;50(12):2738-44. doi: 10.1111/j.1537-2995.2010.02748.x.


Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model.

Vlaar AP, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJ, Tool AT, de Korte D, Juffermans NP.

Blood. 2010 Aug 26;116(8):1360-8. doi: 10.1182/blood-2009-10-248732. Epub 2010 May 17.


Preventing platelet-derived microparticle formation--and possible side effects-with prestorage leukofiltration of whole blood.

Sugawara A, Nollet KE, Yajima K, Saito S, Ohto H.

Arch Pathol Lab Med. 2010 May;134(5):771-5. doi: 10.1043/1543-2165-134.5.771.


Dose of prophylactic platelet transfusions and prevention of hemorrhage.

Slichter SJ, Kaufman RM, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle BA, Woodson RD, Ortel TL, Hillyer CD, Skerrett DL, McCrae KR, Sloan SR, Uhl L, George JN, Aquino VM, Manno CS, McFarland JG, Hess JR, Leissinger C, Granger S.

N Engl J Med. 2010 Feb 18;362(7):600-13. doi: 10.1056/NEJMoa0904084.


Current concepts in platelet transfusion.

Mohanty D.

Asian J Transfus Sci. 2009 Jan;3(1):18-21. doi: 10.4103/0973-6247.45257.


The effects of platelet transfusions evaluated using rotational thromboelastometry.

Flisberg P, Rundgren M, Engström M.

Anesth Analg. 2009 May;108(5):1430-2. doi: 10.1213/ane.0b013e31819bccb7.


The platelet as an immune cell-CD40 ligand and transfusion immunomodulation.

Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP.

Immunol Res. 2009 Dec;45(2-3):251-60. doi: 10.1007/s12026-009-8106-9. Epub 2009 Jan 29. Review.


Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer.

Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH.

Arch Intern Med. 2008 Nov 24;168(21):2377-81. doi: 10.1001/archinte.168.21.2377.


Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells.

Chen C, Chai H, Wang X, Jiang J, Jamaluddin MS, Liao D, Zhang Y, Wang H, Bharadwaj U, Zhang S, Li M, Lin P, Yao Q.

Blood. 2008 Oct 15;112(8):3205-16. doi: 10.1182/blood-2008-03-143479. Epub 2008 Jul 24.


Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge.

Elzey BD, Schmidt NW, Crist SA, Kresowik TP, Harty JT, Nieswandt B, Ratliff TL.

Blood. 2008 Apr 1;111(7):3684-91. doi: 10.1182/blood-2007-05-091728. Epub 2008 Feb 6.


The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.

Donners MM, Beckers L, Lievens D, Munnix I, Heemskerk J, Janssen BJ, Wijnands E, Cleutjens J, Zernecke A, Weber C, Ahonen CL, Benbow U, Newby AC, Noelle RJ, Daemen MJ, Lutgens E.

Blood. 2008 May 1;111(9):4596-604. doi: 10.1182/blood-2007-05-088906. Epub 2008 Jan 14.


Platelet transfusion and survival in adults with acute leukemia.

Blumberg N, Heal JM, Liesveld JL, Phillips GL, Rowe JM.

Leukemia. 2008 Mar;22(3):631-5. Epub 2007 Sep 6. No abstract available.


Human platelets can activate peripheral blood B cells and increase production of immunoglobulins.

Cognasse F, Hamzeh-Cognasse H, Lafarge S, Chavarin P, Cogné M, Richard Y, Garraud O.

Exp Hematol. 2007 Sep;35(9):1376-87. Epub 2007 Jul 25.


TRALI--definition, mechanisms, incidence and clinical relevance.

Toy P, Lowell C.

Best Pract Res Clin Anaesthesiol. 2007 Jun;21(2):183-93.


Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion.

Kaufman J, Spinelli SL, Schultz E, Blumberg N, Phipps RP.

J Thromb Haemost. 2007 Apr;5(4):788-96.


An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions.

Blumberg N, Gettings KF, Turner C, Heal JM, Phipps RP.

Transfusion. 2006 Oct;46(10):1813-21.


Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury.

Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC.

Blood. 2006 Oct 1;108(7):2455-62. Epub 2006 Jun 13.


Transfusion-related acute lung injury and the ICU.

Boshkov LK.

Crit Care Clin. 2005 Jul;21(3):479-95. Review.


Platelets express functional Toll-like receptor-4.

Andonegui G, Kerfoot SM, McNagny K, Ebbert KV, Patel KD, Kubes P.

Blood. 2005 Oct 1;106(7):2417-23. Epub 2005 Jun 16.


Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation.

Elzey BD, Grant JF, Sinn HW, Nieswandt B, Waldschmidt TJ, Ratliff TL.

J Leukoc Biol. 2005 Jul;78(1):80-4. Epub 2005 May 17.


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