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Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase.

Mankouri J, Tedbury PR, Gretton S, Hughes ME, Griffin SD, Dallas ML, Green KA, Hardie DG, Peers C, Harris M.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11549-54. doi: 10.1073/pnas.0912426107. Epub 2010 Jun 7.


Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo.

Ramnanan CJ, Edgerton DS, Rivera N, Irimia-Dominguez J, Farmer B, Neal DW, Lautz M, Donahue EP, Meyer CM, Roach PJ, Cherrington AD.

Diabetes. 2010 Jun;59(6):1302-11. doi: 10.2337/db09-1625. Epub 2010 Feb 25.


Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

Edgerton DS, Ramnanan CJ, Grueter CA, Johnson KM, Lautz M, Neal DW, Williams PE, Cherrington AD.

Diabetes. 2009 Dec;58(12):2766-75. doi: 10.2337/db09-0328. Epub 2009 Sep 15.


Hepatic energy state is regulated by glucagon receptor signaling in mice.

Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH.

J Clin Invest. 2009 Aug;119(8):2412-22.


AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.

Vernia S, Solaz-Fuster MC, Gimeno-Alcañiz JV, Rubio T, García-Haro L, Foretz M, de Córdoba SR, Sanz P.

J Biol Chem. 2009 Mar 27;284(13):8247-55. doi: 10.1074/jbc.M808492200. Epub 2009 Jan 26.


Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.

Ros S, García-Rocha M, Domínguez J, Ferrer JC, Guinovart JJ.

J Biol Chem. 2009 Mar 6;284(10):6370-8. doi: 10.1074/jbc.M808576200. Epub 2009 Jan 5.


A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog.

Rivera N, Everett-Grueter CA, Edgerton DS, Rodewald T, Neal DW, Nishimura E, Larsen MO, Jacobsen LO, Kristensen K, Brand CL, Cherrington AD.

J Pharmacol Exp Ther. 2007 May;321(2):743-52. Epub 2007 Feb 16.


Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.

Hurley RL, Barré LK, Wood SD, Anderson KA, Kemp BE, Means AR, Witters LA.

J Biol Chem. 2006 Dec 1;281(48):36662-72. Epub 2006 Oct 5.


Glucose-6-phosphate dehydrogenase regulation during hypometabolism.

Ramnanan CJ, Storey KB.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):7-16. Epub 2005 Oct 18.


The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.

Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M.

Nature. 2005 Oct 20;437(7062):1109-11. Epub 2005 Sep 7.


5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin.

Camacho RC, Lacy DB, James FD, Donahue EP, Wasserman DH.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1039-43. Epub 2005 Jul 26.


Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog.

Edgerton DS, Cardin S, Neal D, Farmer B, Lautz M, Pan C, Cherrington AD.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E510-22. Epub 2003 Nov 25.


Hypoglycemia in diabetes.

Cryer PE, Davis SN, Shamoon H.

Diabetes Care. 2003 Jun;26(6):1902-12. Review.


Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog.

Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, Donahue EP, Flakoll P, Cherrington AD.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E695-707. Epub 2002 Dec 27.


Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism.

Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD.

Diabetes. 2001 Aug;50(8):1872-82.


Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog.

Dobbins RL, Davis SN, Neal DW, Cobelli C, Cherrington AD.

Am J Physiol. 1994 Mar;266(3 Pt 1):E467-78.


Redundant parasympathetic and sympathoadrenal mediation of increased glucagon secretion during insulin-induced hypoglycemia in conscious rats.

Havel PJ, Parry SJ, Stern JS, Akpan JO, Gingerich RL, Taborsky GJ Jr, Curry DL.

Metabolism. 1994 Jul;43(7):860-6.


Compartmental modeling of glucagon kinetics in the conscious dog.

Dobbins RL, Davis SN, Neal DW, Cobelli C, Jaspan J, Cherrington AD.

Metabolism. 1995 Apr;44(4):452-9.


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