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Items: 1 to 20 of 34

1.

Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells.

Le Goffic R, Bouguyon E, Chevalier C, Vidic J, Da Costa B, Leymarie O, Bourdieu C, Decamps L, Dhorne-Pollet S, Delmas B.

J Immunol. 2010 Oct 15;185(8):4812-23. doi: 10.4049/jimmunol.0903952. Epub 2010 Sep 15.

2.

Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.

Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, Miyazaki T.

J Biol Chem. 2010 Oct 15;285(42):32064-74. doi: 10.1074/jbc.M110.112458. Epub 2010 Aug 10.

3.

PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology.

McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, McCullers JA.

PLoS Pathog. 2010 Jul 22;6(7):e1001014. doi: 10.1371/journal.ppat.1001014.

4.

Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009.

Li Y, Shi J, Zhong G, Deng G, Tian G, Ge J, Zeng X, Song J, Zhao D, Liu L, Jiang Y, Guan Y, Bu Z, Chen H.

J Virol. 2010 Sep;84(17):8389-97. doi: 10.1128/JVI.00413-10. Epub 2010 Jun 10.

5.

The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.

Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, Fodor E.

J Virol. 2010 Sep;84(17):8433-45. doi: 10.1128/JVI.00879-10. Epub 2010 Jun 10.

6.

Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection.

Cilloniz C, Pantin-Jackwood MJ, Ni C, Goodman AG, Peng X, Proll SC, Carter VS, Rosenzweig ER, Szretter KJ, Katz JM, Korth MJ, Swayne DE, Tumpey TM, Katze MG.

J Virol. 2010 Aug;84(15):7613-24. doi: 10.1128/JVI.00553-10. Epub 2010 May 26.

7.

PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models.

Hai R, Schmolke M, Varga ZT, Manicassamy B, Wang TT, Belser JA, Pearce MB, García-Sastre A, Tumpey TM, Palese P.

J Virol. 2010 May;84(9):4442-50. doi: 10.1128/JVI.02717-09. Epub 2010 Feb 24.

8.

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host.

Gao Y, Zhang Y, Shinya K, Deng G, Jiang Y, Li Z, Guan Y, Tian G, Li Y, Shi J, Liu L, Zeng X, Bu Z, Xia X, Kawaoka Y, Chen H.

PLoS Pathog. 2009 Dec;5(12):e1000709. doi: 10.1371/journal.ppat.1000709. Epub 2009 Dec 24.

9.

The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.

Goodman AG, Zeng H, Proll SC, Peng X, Cillóniz C, Carter VS, Korth MJ, Tumpey TM, Katze MG.

J Virol. 2010 Feb;84(4):2027-37. doi: 10.1128/JVI.01595-09. Epub 2009 Nov 25.

10.

The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis.

McAuley JL, Zhang K, McCullers JA.

J Virol. 2010 Jan;84(1):558-64. doi: 10.1128/JVI.01785-09.

11.

Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes.

Cillóniz C, Shinya K, Peng X, Korth MJ, Proll SC, Aicher LD, Carter VS, Chang JH, Kobasa D, Feldmann F, Strong JE, Feldmann H, Kawaoka Y, Katze MG.

PLoS Pathog. 2009 Oct;5(10):e1000604. doi: 10.1371/journal.ppat.1000604. Epub 2009 Oct 2.

12.

A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice.

Fornek JL, Gillim-Ross L, Santos C, Carter V, Ward JM, Cheng LI, Proll S, Katze MG, Subbarao K.

J Virol. 2009 Nov;83(21):11102-15. doi: 10.1128/JVI.00994-09. Epub 2009 Aug 19.

13.

Early control of H5N1 influenza virus replication by the type I interferon response in mice.

Szretter KJ, Gangappa S, Belser JA, Zeng H, Chen H, Matsuoka Y, Sambhara S, Swayne DE, Tumpey TM, Katz JM.

J Virol. 2009 Jun;83(11):5825-34. doi: 10.1128/JVI.02144-08. Epub 2009 Mar 18.

14.

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.

Baskin CR, Bielefeldt-Ohmann H, Tumpey TM, Sabourin PJ, Long JP, García-Sastre A, Tolnay AE, Albrecht R, Pyles JA, Olson PH, Aicher LD, Rosenzweig ER, Murali-Krishna K, Clark EA, Kotur MS, Fornek JL, Proll S, Palermo RE, Sabourin CL, Katze MG.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3455-60. doi: 10.1073/pnas.0813234106. Epub 2009 Feb 13.

15.

H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.

Perrone LA, Plowden JK, García-Sastre A, Katz JM, Tumpey TM.

PLoS Pathog. 2008 Aug 1;4(8):e1000115. doi: 10.1371/journal.ppat.1000115.

16.

Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses.

Chen LM, Davis CT, Zhou H, Cox NJ, Donis RO.

PLoS Pathog. 2008 May 23;4(5):e1000072. doi: 10.1371/journal.ppat.1000072.

17.

NP, PB1, and PB2 viral genes contribute to altered replication of H5N1 avian influenza viruses in chickens.

Wasilenko JL, Lee CW, Sarmento L, Spackman E, Kapczynski DR, Suarez DL, Pantin-Jackwood MJ.

J Virol. 2008 May;82(9):4544-53. doi: 10.1128/JVI.02642-07. Epub 2008 Feb 27.

18.

The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein.

Mazur I, Anhlan D, Mitzner D, Wixler L, Schubert U, Ludwig S.

Cell Microbiol. 2008 May;10(5):1140-52. doi: 10.1111/j.1462-5822.2008.01116.x. Epub 2008 Jan 7.

PMID:
18182088
19.

Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.

McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA.

Cell Host Microbe. 2007 Oct 11;2(4):240-9.

20.

A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence.

Conenello GM, Zamarin D, Perrone LA, Tumpey T, Palese P.

PLoS Pathog. 2007 Oct 5;3(10):1414-21.

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