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Items: 1 to 20 of 47

1.

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.

Manfredi JJ.

Genes Dev. 2010 Aug 1;24(15):1580-9. doi: 10.1101/gad.1941710. Review. Erratum in: Genes Dev. 2010 Sep 15;24(18):2105.

2.

The regulatory crosstalk between kinases and proteases in cancer.

López-Otín C, Hunter T.

Nat Rev Cancer. 2010 Apr;10(4):278-92. doi: 10.1038/nrc2823. Epub 2010 Mar 19. Review.

PMID:
20300104
3.

Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.

El Hour M, Moncada-Pazos A, Blacher S, Masset A, Cal S, Berndt S, Detilleux J, Host L, Obaya AJ, Maillard C, Foidart JM, Ectors F, Noel A, Lopez-Otin C.

Oncogene. 2010 May 20;29(20):3025-32. doi: 10.1038/onc.2010.49. Epub 2010 Mar 8.

4.

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products.

Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM.

Nat Biotechnol. 2010 Mar;28(3):281-8. doi: 10.1038/nbt.1611. Epub 2010 Mar 7.

PMID:
20208520
5.

Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.

Davies MA, Stemke-Hale K, Lin E, Tellez C, Deng W, Gopal YN, Woodman SE, Calderone TC, Ju Z, Lazar AJ, Prieto VG, Aldape K, Mills GB, Gershenwald JE.

Clin Cancer Res. 2009 Dec 15;15(24):7538-7546.

6.

High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers.

Li Z, Zhang W, Shao Y, Zhang C, Wu Q, Yang H, Wan X, Zhang J, Guan M, Wan J, Yu B.

Med Oncol. 2010 Sep;27(3):998-1004. doi: 10.1007/s12032-009-9323-8. Epub 2009 Oct 6.

PMID:
19806480
7.

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR, Cronin JC, Cruz P, Rosenberg SA, Samuels Y.

Nat Genet. 2009 Oct;41(10):1127-32. doi: 10.1038/ng.438. Epub 2009 Aug 30.

8.

Structural and functional alterations of FLT3 in acute myeloid leukemia.

Meshinchi S, Appelbaum FR.

Clin Cancer Res. 2009 Jul 1;15(13):4263-9. doi: 10.1158/1078-0432.CCR-08-1123. Epub 2009 Jun 23. Review.

9.

Cancer statistics, 2009.

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ.

CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49. doi: 10.3322/caac.20006. Epub 2009 May 27.

10.

Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.

Viloria CG, Obaya AJ, Moncada-Pazos A, Llamazares M, Astudillo A, Capellá G, Cal S, López-Otín C.

Cancer Res. 2009 Jun 1;69(11):4926-34. doi: 10.1158/0008-5472.CAN-08-4155. Epub 2009 May 19.

11.

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y.

Nat Genet. 2009 May;41(5):518-20. doi: 10.1038/ng.340. Epub 2009 Mar 29.

12.

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

Solomon DA, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T.

Cancer Res. 2008 Dec 15;68(24):10300-6. doi: 10.1158/0008-5472.CAN-08-3272.

13.

Proteases: multifunctional enzymes in life and disease.

López-Otín C, Bond JS.

J Biol Chem. 2008 Nov 7;283(45):30433-7. doi: 10.1074/jbc.R800035200. Epub 2008 Jul 23. Review. No abstract available.

14.

The secreted metalloprotease ADAMTS20 is required for melanoblast survival.

Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ.

PLoS Genet. 2008 Feb 29;4(2):e1000003. doi: 10.1371/journal.pgen.1000003.

15.

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.

Gutiérrez-Fernández A, Fueyo A, Folgueras AR, Garabaya C, Pennington CJ, Pilgrim S, Edwards DR, Holliday DL, Jones JL, Span PN, Sweep FC, Puente XS, López-Otín C.

Cancer Res. 2008 Apr 15;68(8):2755-63. doi: 10.1158/0008-5472.CAN-07-5154.

16.

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.

Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM.

Science. 2008 Mar 21;319(5870):1676-9. doi: 10.1126/science.1153629. Epub 2008 Mar 6.

17.

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.

Fushimi K, Troeberg L, Nakamura H, Lim NH, Nagase H.

J Biol Chem. 2008 Mar 14;283(11):6706-16. Epub 2007 Dec 22.

18.

The genomic landscapes of human breast and colorectal cancers.

Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B.

Science. 2007 Nov 16;318(5853):1108-13. Epub 2007 Oct 11.

19.

Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.

Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gueders M, Foidart JM, Noel A, Cataldo D.

Biochimie. 2008 Feb;90(2):369-79. Epub 2007 Sep 2. Review.

20.

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway.

Llamazares M, Obaya AJ, Moncada-Pazos A, Heljasvaara R, Espada J, López-Otín C, Cal S.

J Cell Sci. 2007 Oct 15;120(Pt 20):3544-52. Epub 2007 Sep 25.

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