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Items: 1 to 20 of 39

1.

Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene.

Nishioka C, Ikezoe T, Yang J, Yokoyama A.

Leukemia. 2010 Sep;24(9):1631-40. doi: 10.1038/leu.2010.145. Epub 2010 Jul 1.

PMID:
20596030
2.

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC.

FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.

3.

Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo.

Chen C, Li G, Liao W, Wu J, Liu L, Ma D, Zhou J, Elbekai RH, Edin ML, Zeldin DC, Wang DW.

J Pharmacol Exp Ther. 2009 Jun;329(3):908-18. doi: 10.1124/jpet.109.152017. Epub 2009 Mar 16.

4.

Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma.

Drakos E, Atsaves V, Li J, Leventaki V, Andreeff M, Medeiros LJ, Rassidakis GZ.

Leukemia. 2009 Apr;23(4):784-90. doi: 10.1038/leu.2008.348. Epub 2009 Feb 19.

PMID:
19225536
5.

c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia.

Lagadinou ED, Ziros PG, Tsopra OA, Dimas K, Kokkinou D, Thanopoulou E, Karakantza M, Pantazis P, Spyridonidis A, Zoumbos NC.

Leukemia. 2008 Oct;22(10):1899-908. doi: 10.1038/leu.2008.192. Epub 2008 Jul 24.

PMID:
18650843
6.

Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.

Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL.

J Natl Cancer Inst. 2008 Jul 16;100(14):1022-36. doi: 10.1093/jnci/djn214. Epub 2008 Jul 8.

7.

Aberrant cytokine signaling in leukemia.

Van Etten RA.

Oncogene. 2007 Oct 15;26(47):6738-49. Review.

8.

Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside.

Martelli AM, Tazzari PL, Evangelisti C, Chiarini F, Blalock WL, Billi AM, Manzoli L, McCubrey JA, Cocco L.

Curr Med Chem. 2007;14(19):2009-23. Review.

PMID:
17691943
9.

Cytochrome p450 epoxygenase promotes human cancer metastasis.

Jiang JG, Ning YG, Chen C, Ma D, Liu ZJ, Yang S, Zhou J, Xiao X, Zhang XA, Edin ML, Card JW, Wang J, Zeldin DC, Wang DW.

Cancer Res. 2007 Jul 15;67(14):6665-74.

10.

Targeting RAS signaling pathways in juvenile myelomonocytic leukemia.

Flotho C, Kratz C, Niemeyer CM.

Curr Drug Targets. 2007 Jun;8(6):715-25. Review.

PMID:
17584027
11.

The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.

Mikesch JH, Steffen B, Berdel WE, Serve H, Müller-Tidow C.

Leukemia. 2007 Aug;21(8):1638-47. Epub 2007 Jun 7. Review.

PMID:
17554387
12.

Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.

Yang S, Lin L, Chen JX, Lee CR, Seubert JM, Wang Y, Wang H, Chao ZR, Tao DD, Gong JP, Lu ZY, Wang DW, Zeldin DC.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H142-51. Epub 2007 Feb 23.

13.

Epoxyeicosatrienoic acids, cell signaling and angiogenesis.

Fleming I.

Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):60-7. Epub 2006 Jul 11. Review.

PMID:
17164133
14.

Cytochrome P450 enzymes: central players in cardiovascular health and disease.

Elbekai RH, El-Kadi AO.

Pharmacol Ther. 2006 Nov;112(2):564-87. Epub 2006 Jul 7. Review.

PMID:
16824612
15.

Emerging role of epoxyeicosatrienoic acids in coronary vascular function.

Larsen BT, Gutterman DD, Hatoum OA.

Eur J Clin Invest. 2006 May;36(5):293-300. Review.

PMID:
16634832
16.

Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.

Lafite P, Dijols S, Buisson D, Macherey AC, Zeldin DC, Dansette PM, Mansuy D.

Bioorg Med Chem Lett. 2006 May 15;16(10):2777-80. Epub 2006 Feb 21.

17.

Deregulated TGF-beta signaling in leukemogenesis.

Lin HK, Bergmann S, Pandolfi PP.

Oncogene. 2005 Aug 29;24(37):5693-700. Review.

PMID:
16123802
18.

The role of CREB as a proto-oncogene in hematopoiesis.

Kinjo K, Sandoval S, Sakamoto KM, Shankar DB.

Cell Cycle. 2005 Sep;4(9):1134-5. Epub 2005 Sep 6. Review.

PMID:
16096372
19.

Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.

Jiang JG, Chen CL, Card JW, Yang S, Chen JX, Fu XN, Ning YG, Xiao X, Zeldin DC, Wang DW.

Cancer Res. 2005 Jun 1;65(11):4707-15.

20.

Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase.

Bacchiocchi R, Baldanzi G, Carbonari D, Capomagi C, Colombo E, van Blitterswijk WJ, Graziani A, Fazioli F.

Blood. 2005 Sep 15;106(6):2175-82. Epub 2005 May 31.

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