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Items: 1 to 20 of 33

1.

Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2.

Spratlin JL, Cohen RB, Eadens M, Gore L, Camidge DR, Diab S, Leong S, O'Bryant C, Chow LQ, Serkova NJ, Meropol NJ, Lewis NL, Chiorean EG, Fox F, Youssoufian H, Rowinsky EK, Eckhardt SG.

J Clin Oncol. 2010 Feb 10;28(5):780-7. doi: 10.1200/JCO.2009.23.7537. Epub 2010 Jan 4.

2.
3.

Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression.

Gao D, Nolan D, McDonnell K, Vahdat L, Benezra R, Altorki N, Mittal V.

Biochim Biophys Acta. 2009 Aug;1796(1):33-40. doi: 10.1016/j.bbcan.2009.05.001. Epub 2009 May 19. Review.

4.

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation.

Chen SH, Murphy DA, Lassoued W, Thurston G, Feldman MD, Lee WM.

Cancer Biol Ther. 2008 Dec;7(12):1994-2003. Epub 2008 Dec 11.

5.

Modes of resistance to anti-angiogenic therapy.

Bergers G, Hanahan D.

Nat Rev Cancer. 2008 Aug;8(8):592-603. doi: 10.1038/nrc2442. Review.

6.

Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.

Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F.

Cancer Cell. 2008 May;13(5):420-31. doi: 10.1016/j.ccr.2008.02.018.

7.

Effect of molecular therapeutics on liver regeneration in a murine model.

Van Buren G 2nd, Yang AD, Dallas NA, Gray MJ, Lim SJ, Xia L, Fan F, Somcio R, Wu Y, Hicklin DJ, Ellis LM.

J Clin Oncol. 2008 Apr 10;26(11):1836-42. doi: 10.1200/JCO.2007.11.6566.

PMID:
18398149
8.

Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.

Fernando NT, Koch M, Rothrock C, Gollogly LK, D'Amore PA, Ryeom S, Yoon SS.

Clin Cancer Res. 2008 Mar 1;14(5):1529-39. doi: 10.1158/1078-0432.CCR-07-4126.

9.

Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells.

Dallas NA, Fan F, Gray MJ, Van Buren G 2nd, Lim SJ, Xia L, Ellis LM.

Cancer Metastasis Rev. 2007 Dec;26(3-4):433-41. Review.

PMID:
17786539
10.

Genes that distinguish physiological and pathological angiogenesis.

Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B.

Cancer Cell. 2007 Jun;11(6):539-54.

11.

Therapeutic options to target angiogenesis in human malignancies.

Herbst RS.

Expert Opin Emerg Drugs. 2006 Nov;11(4):635-50. Review.

PMID:
17064223
12.

Vascular endothelial growth factor localization in the adult.

Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA.

Am J Pathol. 2006 Feb;168(2):639-48.

13.

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.

Casanovas O, Hicklin DJ, Bergers G, Hanahan D.

Cancer Cell. 2005 Oct;8(4):299-309.

14.

Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.

Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS.

Cancer Res. 2005 Jul 1;65(13):5881-9.

15.

Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy.

Ferrara N, Hillan KJ, Novotny W.

Biochem Biophys Res Commun. 2005 Jul 29;333(2):328-35. Review.

PMID:
15961063
16.

Contribution of bone marrow-derived endothelial cells to human tumor vasculature.

Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, Kinzler KW, Lengauer C.

Nat Med. 2005 Mar;11(3):261-2. Epub 2005 Feb 20.

PMID:
15723071
17.

Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development.

McGrath-Morrow SA, Cho C, Cho C, Zhen L, Hicklin DJ, Tuder RM.

Am J Respir Cell Mol Biol. 2005 May;32(5):420-7. Epub 2005 Feb 18.

PMID:
15722510
18.

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.

Hicklin DJ, Ellis LM.

J Clin Oncol. 2005 Feb 10;23(5):1011-27. Epub 2004 Dec 7. Review.

PMID:
15585754
19.

The diversity of endothelial cells: a challenge for therapeutic angiogenesis.

Conway EM, Carmeliet P.

Genome Biol. 2004;5(2):207. Epub 2004 Jan 29. Review.

20.

Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse.

Zhang N, Fang Z, Contag PR, Purchio AF, West DB.

Blood. 2004 Jan 15;103(2):617-26. Epub 2003 Sep 25.

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