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Items: 1 to 20 of 56

1.

Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N.

J Cell Physiol. 2011 Mar;226(3):627-37. doi: 10.1002/jcp.22384.

2.

Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins.

Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N.

J Cell Physiol. 2010 Nov;225(2):406-16. doi: 10.1002/jcp.22289.

3.

Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling.

Valanne S, Myllymäki H, Kallio J, Schmid MR, Kleino A, Murumägi A, Airaksinen L, Kotipelto T, Kaustio M, Ulvila J, Esfahani SS, Engström Y, Silvennoinen O, Hultmark D, Parikka M, Rämet M.

J Immunol. 2010 Jun 1;184(11):6188-98. doi: 10.4049/jimmunol.1000261. Epub 2010 Apr 26.

4.

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases.

Pasparakis M.

Nat Rev Immunol. 2009 Nov;9(11):778-88. doi: 10.1038/nri2655. Review.

PMID:
19855404
5.

G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N.

Biochem J. 2009 Dec 14;425(1):169-78. doi: 10.1042/BJ20090908.

6.

Regulation and function of NF-kappaB transcription factors in the immune system.

Vallabhapurapu S, Karin M.

Annu Rev Immunol. 2009;27:693-733. doi: 10.1146/annurev.immunol.021908.132641. Review.

PMID:
19302050
7.

Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.

Ishikado A, Nishio Y, Yamane K, Mukose A, Morino K, Murakami Y, Sekine O, Makino T, Maegawa H, Kashiwagi A.

Atherosclerosis. 2009 Aug;205(2):404-12. doi: 10.1016/j.atherosclerosis.2009.01.010. Epub 2009 Jan 19.

PMID:
19215923
8.

Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential.

Wong ET, Tergaonkar V.

Clin Sci (Lond). 2009 Mar;116(6):451-65. doi: 10.1042/CS20080502. Review.

PMID:
19200055
9.

Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.

Beutler B.

Immunol Rev. 2009 Jan;227(1):248-63. doi: 10.1111/j.1600-065X.2008.00733.x. Review.

10.

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.

Baud V, Karin M.

Nat Rev Drug Discov. 2009 Jan;8(1):33-40. doi: 10.1038/nrd2781. Review.

11.

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.

Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17818-23. doi: 10.1073/pnas.0804446105. Epub 2008 Nov 13.

12.

Harmful molecular mechanisms in sepsis.

Rittirsch D, Flierl MA, Ward PA.

Nat Rev Immunol. 2008 Oct;8(10):776-87. doi: 10.1038/nri2402. Review.

13.

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

Martini JS, Raake P, Vinge LE, DeGeorge BR Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62. doi: 10.1073/pnas.0803153105. Epub 2008 Aug 18. Erratum in: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17206. DeGeorge, Brent Jr [corrected to DeGeorge, Brent R Jr].

14.

Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo.

Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N, Amalfitano A.

J Immunol. 2008 Aug 1;181(3):2134-44.

15.

Role of MCP-1 in endotoxemia and sepsis.

Ramnath RD, Ng SW, Guglielmotti A, Bhatia M.

Int Immunopharmacol. 2008 Jun;8(6):810-8. doi: 10.1016/j.intimp.2008.01.033. Epub 2008 Mar 18.

PMID:
18442784
16.

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.

Loniewski K, Shi Y, Pestka J, Parameswaran N.

Mol Immunol. 2008 Apr;45(8):2312-22. doi: 10.1016/j.molimm.2007.11.012. Epub 2008 Jan 4.

PMID:
18180038
17.

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.

Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M.

Cell. 2007 Sep 7;130(5):918-31.

18.

Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.

Loniewski KJ, Patial S, Parameswaran N.

Mol Immunol. 2007 Jul;44(15):3715-23. Epub 2007 May 15.

PMID:
17507094
19.

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.

O'Neill LA, Bowie AG.

Nat Rev Immunol. 2007 May;7(5):353-64. Review.

PMID:
17457343
20.

Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.

Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL.

J Biol Chem. 2006 Nov 10;281(45):34159-70. Epub 2006 Sep 15.

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