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Items: 1 to 20 of 51

1.

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B.

Immunity. 2009 Aug 21;31(2):197-208. doi: 10.1016/j.immuni.2009.05.013. Epub 2009 Aug 13.

2.

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

Guo F, Velu CS, Grimes HL, Zheng Y.

Blood. 2009 Oct 1;114(14):2909-16. doi: 10.1182/blood-2009-04-214676. Epub 2009 Aug 11.

3.

T cell activation.

Smith-Garvin JE, Koretzky GA, Jordan MS.

Annu Rev Immunol. 2009;27:591-619. doi: 10.1146/annurev.immunol.021908.132706. Review.

4.

Homeostasis of naive and memory T cells.

Surh CD, Sprent J.

Immunity. 2008 Dec 19;29(6):848-62. doi: 10.1016/j.immuni.2008.11.002. Review.

5.

Rho GTPase-mediated pathways in mature CD4+ T cells.

Pernis AB.

Autoimmun Rev. 2009 Jan;8(3):199-203. doi: 10.1016/j.autrev.2008.07.044. Epub 2008 Aug 22. Review.

PMID:
18723130
6.

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

Guo F, Cancelas JA, Hildeman D, Williams DA, Zheng Y.

Blood. 2008 Sep 1;112(5):1767-75. doi: 10.1182/blood-2008-01-132068. Epub 2008 Jun 25.

7.

TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.

Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH.

Cell. 2008 May 2;133(3):415-26. doi: 10.1016/j.cell.2008.03.026.

8.

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival.

Junttila MR, Li SP, Westermarck J.

FASEB J. 2008 Apr;22(4):954-65. Epub 2007 Nov 26. Review.

PMID:
18039929
9.

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9. Epub 2007 Sep 18.

10.

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.

Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA, Zheng Y.

Blood. 2007 Dec 1;110(12):3853-61. Epub 2007 Aug 16.

11.

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.

Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA.

J Exp Med. 2007 Jul 9;204(7):1665-75. Epub 2007 Jun 25.

12.

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo.

Bustelo XR, Sauzeau V, Berenjeno IM.

Bioessays. 2007 Apr;29(4):356-70. Review.

13.

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.

Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5091-6. Epub 2007 Mar 12.

14.

Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.

Wang L, Zheng Y.

Trends Cell Biol. 2007 Feb;17(2):58-64. Epub 2006 Dec 11.

PMID:
17161947
15.

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils.

Szczur K, Xu H, Atkinson S, Zheng Y, Filippi MD.

Blood. 2006 Dec 15;108(13):4205-13. Epub 2006 Aug 24.

16.

Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.

Tskvitaria-Fuller I, Seth A, Mistry N, Gu H, Rosen MK, Wülfing C.

J Immunol. 2006 Aug 1;177(3):1708-20.

17.

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.

Czuchra A, Wu X, Meyer H, van Hengel J, Schroeder T, Geffers R, Rottner K, Brakebusch C.

Mol Biol Cell. 2005 Oct;16(10):4473-84. Epub 2005 Jul 12. Erratum in: Mol Biol Cell. 2005 Dec;16(12):5901.

18.
19.

Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

Phee H, Abraham RT, Weiss A.

Nat Immunol. 2005 Jun;6(6):608-17. Epub 2005 May 1.

PMID:
15864311
20.

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.

Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K.

Dev Cell. 2004 Dec;7(6):871-83.

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