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Items: 1 to 20 of 63


Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC.

Nat Struct Mol Biol. 2010 Nov;17(11):1312-7. doi: 10.1038/nsmb.1938. Epub 2010 Oct 24.


Notch signaling in the immune system.

Radtke F, Fasnacht N, Macdonald HR.

Immunity. 2010 Jan 29;32(1):14-27. doi: 10.1016/j.immuni.2010.01.004. Review.


Thermodynamic and structural insights into CSL-DNA complexes.

Friedmann DR, Kovall RA.

Protein Sci. 2010 Jan;19(1):34-46. doi: 10.1002/pro.280.


Elucidating the role of 8q24 in colorectal cancer.

Harismendy O, Frazer KA.

Nat Genet. 2009 Aug;41(8):868-9. doi: 10.1038/ng0809-868. No abstract available. Erratum in: Nat Genet. 2009 Oct;41(10):1156.


Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS.

Genes Dev. 2009 Jul 15;23(14):1665-76. doi: 10.1101/gad.1793709.


The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.

Pomerantz MM, Ahmadiyeh N, Jia L, Herman P, Verzi MP, Doddapaneni H, Beckwith CA, Chan JA, Hills A, Davis M, Yao K, Kehoe SM, Lenz HJ, Haiman CA, Yan C, Henderson BE, Frenkel B, Barretina J, Bass A, Tabernero J, Baselga J, Regan MM, Manak JR, Shivdasani R, Coetzee GA, Freedman ML.

Nat Genet. 2009 Aug;41(8):882-4. doi: 10.1038/ng.403. Epub 2009 Jun 28.


The canonical Notch signaling pathway: unfolding the activation mechanism.

Kopan R, Ilagan MX.

Cell. 2009 Apr 17;137(2):216-33. doi: 10.1016/j.cell.2009.03.045. Review.


CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia.

González-García S, García-Peydró M, Martín-Gayo E, Ballestar E, Esteller M, Bornstein R, de la Pompa JL, Ferrando AA, Toribio ML.

J Exp Med. 2009 Apr 13;206(4):779-91. doi: 10.1084/jem.20081922. Epub 2009 Apr 6. Erratum in: J Exp Med. 2009 Jul 6;206(7):1633.


JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E.

Cancer Cell. 2009 Apr 7;15(4):341-52. doi: 10.1016/j.ccr.2009.02.016.


Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.

Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H.

J Exp Med. 2008 Nov 24;205(12):2851-61. doi: 10.1084/jem.20081561. Epub 2008 Nov 3.


Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, Pierres M, Manley NR, Duarte A, Macdonald HR, Radtke F.

J Exp Med. 2008 Oct 27;205(11):2515-23. doi: 10.1084/jem.20080829. Epub 2008 Sep 29.


Delta-like 4 is indispensable in thymic environment specific for T cell development.

Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Holländer GA, Shima DT, Habu S.

J Exp Med. 2008 Oct 27;205(11):2507-13. doi: 10.1084/jem.20080134. Epub 2008 Sep 29.


The molecular logic of Notch signaling--a structural and biochemical perspective.

Gordon WR, Arnett KL, Blacklow SC.

J Cell Sci. 2008 Oct 1;121(Pt 19):3109-19. doi: 10.1242/jcs.035683. Review.


Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

Chiang MY, Xu L, Shestova O, Histen G, L'heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS.

J Clin Invest. 2008 Sep;118(9):3181-94. doi: 10.1172/JCI35090.


Notch signaling in leukemia.

Aster JC, Pear WS, Blacklow SC.

Annu Rev Pathol. 2008;3:587-613. Review.


Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from.

Bhandoola A, von Boehmer H, Petrie HT, Zúñiga-Pflücker JC.

Immunity. 2007 Jun;26(6):678-89. Review.


Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing.

Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Talora C, Frati L, Gulino A, Screpanti I.

EMBO J. 2007 Mar 21;26(6):1670-80. Epub 2007 Mar 1.


Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.

Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2103-8. Epub 2007 Feb 6.


NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.

Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. Epub 2006 Nov 17. Erratum in: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4240.


The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

Maillard I, Tu L, Sambandam A, Yashiro-Ohtani Y, Millholland J, Keeshan K, Shestova O, Xu L, Bhandoola A, Pear WS.

J Exp Med. 2006 Oct 2;203(10):2239-45. Epub 2006 Sep 11.

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