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Items: 1 to 20 of 89


Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.

Kumar D, Abdulovic AL, Viberg J, Nilsson AK, Kunkel TA, Chabes A.

Nucleic Acids Res. 2011 Mar;39(4):1360-71. doi: 10.1093/nar/gkq829. Epub 2010 Oct 20.


Genome-wide model for the normal eukaryotic DNA replication fork.

Larrea AA, Lujan SA, Nick McElhinny SA, Mieczkowski PA, Resnick MA, Gordenin DA, Kunkel TA.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17674-9. doi: 10.1073/pnas.1010178107. Epub 2010 Sep 27.


Genome instability due to ribonucleotide incorporation into DNA.

Nick McElhinny SA, Kumar D, Clark AB, Watt DL, Watts BE, Lundström EB, Johansson E, Chabes A, Kunkel TA.

Nat Chem Biol. 2010 Oct;6(10):774-81. doi: 10.1038/nchembio.424. Epub 2010 Aug 22.


What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats.

Kelkar YD, Strubczewski N, Hile SE, Chiaromonte F, Eckert KA, Makova KD.

Genome Biol Evol. 2010;2:620-35. doi: 10.1093/gbe/evq046. Epub 2010 Jul 28.


A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast.

Yang Y, Gordenin DA, Resnick MA.

DNA Repair (Amst). 2010 Aug 5;9(8):914-21. doi: 10.1016/j.dnarep.2010.06.005. Epub 2010 Jul 21.


Structure and mechanism of human DNA polymerase eta.

Biertümpfel C, Zhao Y, Kondo Y, Ramón-Maiques S, Gregory M, Lee JY, Masutani C, Lehmann AR, Hanaoka F, Yang W.

Nature. 2010 Jun 24;465(7301):1044-8. doi: 10.1038/nature09196. Erratum in: Nature. 2011 Aug 18;476(7360):360.


Structural basis for the suppression of skin cancers by DNA polymerase eta.

Silverstein TD, Johnson RE, Jain R, Prakash L, Prakash S, Aggarwal AK.

Nature. 2010 Jun 24;465(7301):1039-43. doi: 10.1038/nature09104.


Ubiquitin-dependent DNA damage bypass is separable from genome replication.

Daigaku Y, Davies AA, Ulrich HD.

Nature. 2010 Jun 17;465(7300):951-5. doi: 10.1038/nature09097. Epub 2010 May 9.


Loss of DNA polymerase zeta enhances spontaneous tumorigenesis.

Wittschieben JP, Patil V, Glushets V, Robinson LJ, Kusewitt DF, Wood RD.

Cancer Res. 2010 Apr 1;70(7):2770-8. doi: 10.1158/0008-5472.CAN-09-4267. Epub 2010 Mar 9.


Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.

Kumar D, Viberg J, Nilsson AK, Chabes A.

Nucleic Acids Res. 2010 Jul;38(12):3975-83. doi: 10.1093/nar/gkq128. Epub 2010 Mar 9.


Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis.

Livneh Z, Ziv O, Shachar S.

Cell Cycle. 2010 Feb 15;9(4):729-35. Epub 2010 Feb 23. Review.


The mitochondrial DNA polymerase in health and disease.

Copeland WC.

Subcell Biochem. 2010;50:211-22. doi: 10.1007/978-90-481-3471-7_11. Review.


Evolving views of DNA replication (in)fidelity.

Kunkel TA.

Cold Spring Harb Symp Quant Biol. 2009;74:91-101. doi: 10.1101/sqb.2009.74.027. Epub 2009 Nov 10. Review.


Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications.

Lynch HT, Lynch PM, Lanspa SJ, Snyder CL, Lynch JF, Boland CR.

Clin Genet. 2009 Jul;76(1):1-18. doi: 10.1111/j.1399-0004.2009.01230.x. Review.


DNA polymerase proofreading: Multiple roles maintain genome stability.

Reha-Krantz LJ.

Biochim Biophys Acta. 2010 May;1804(5):1049-63. doi: 10.1016/j.bbapap.2009.06.012. Epub 2009 Jun 21. Review.


Coordinating DNA polymerase traffic during high and low fidelity synthesis.

Sutton MD.

Biochim Biophys Acta. 2010 May;1804(5):1167-79. doi: 10.1016/j.bbapap.2009.06.010. Epub 2009 Jun 21. Review.


High fidelity and lesion bypass capability of human DNA polymerase delta.

Schmitt MW, Matsumoto Y, Loeb LA.

Biochimie. 2009 Sep;91(9):1163-72. doi: 10.1016/j.biochi.2009.06.007. Epub 2009 Jun 18.


Y-family DNA polymerases in mammalian cells.

Guo C, Kosarek-Stancel JN, Tang TS, Friedberg EC.

Cell Mol Life Sci. 2009 Jul;66(14):2363-81. doi: 10.1007/s00018-009-0024-4. Epub 2009 Apr 15. Review.


Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance.

Waters LS, Minesinger BK, Wiltrout ME, D'Souza S, Woodruff RV, Walker GC.

Microbiol Mol Biol Rev. 2009 Mar;73(1):134-54. doi: 10.1128/MMBR.00034-08. Review.


Bypass specialists operate together.

Takata K, Wood RD.

EMBO J. 2009 Feb 18;28(4):313-4. doi: 10.1038/emboj.2008.303. Review.

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