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Items: 1 to 20 of 60

1.

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.

Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP.

Nature. 2009 Dec 17;462(7275):935-9. doi: 10.1038/nature08657.

2.

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E.

Nature. 2009 Dec 17;462(7275):886-90. doi: 10.1038/nature08593.

PMID:
20016594
3.

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD.

Nat Cell Biol. 2009 Nov;11(11):1376-82. doi: 10.1038/ncb1982. Epub 2009 Sep 27.

4.

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.

Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R.

Nat Biotechnol. 2009 Sep;27(9):851-7. doi: 10.1038/nbt.1562. Epub 2009 Aug 13.

5.

Chromosomal translocations induced at specified loci in human stem cells.

Brunet E, Simsek D, Tomishima M, DeKelver R, Choi VM, Gregory P, Urnov F, Weinstock DM, Jasin M.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10620-5. doi: 10.1073/pnas.0902076106. Epub 2009 Jun 23.

6.

Histone acetylation: truth of consequences?

Choi JK, Howe LJ.

Biochem Cell Biol. 2009 Feb;87(1):139-50. doi: 10.1139/O08-112. Review.

PMID:
19234530
7.

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.

Cell. 2009 Feb 6;136(3):435-46. doi: 10.1016/j.cell.2008.12.041.

8.

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.

Cell. 2009 Feb 6;136(3):420-34. doi: 10.1016/j.cell.2008.12.042.

9.

The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.

Mattera L, Escaffit F, Pillaire MJ, Selves J, Tyteca S, Hoffmann JS, Gourraud PA, Chevillard-Briet M, Cazaux C, Trouche D.

Oncogene. 2009 Mar 26;28(12):1506-17. doi: 10.1038/onc.2008.499. Epub 2009 Jan 26.

PMID:
19169279
10.

GammaH2AX and cancer.

Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y.

Nat Rev Cancer. 2008 Dec;8(12):957-67. doi: 10.1038/nrc2523. Epub 2008 Nov 13. Review.

11.

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA.

Mol Cell. 2008 Jul 25;31(2):167-77. doi: 10.1016/j.molcel.2008.05.017.

12.

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M.

J Cell Biol. 2008 Apr 21;181(2):227-40. doi: 10.1083/jcb.200709008. Epub 2008 Apr 14.

13.

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J.

J Cell Biol. 2008 Apr 21;181(2):213-26. doi: 10.1083/jcb.200708210. Epub 2008 Apr 14.

14.

Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.

Jha S, Shibata E, Dutta A.

Mol Cell Biol. 2008 Apr;28(8):2690-700. doi: 10.1128/MCB.01983-07. Epub 2008 Feb 19.

15.

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.

Science. 2007 Dec 7;318(5856):1637-40. Epub 2007 Nov 15.

16.

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J.

Cell. 2007 Nov 30;131(5):901-14. Epub 2007 Nov 20.

17.

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.

19.

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.

Sun Y, Xu Y, Roy K, Price BD.

Mol Cell Biol. 2007 Dec;27(24):8502-9. Epub 2007 Oct 8.

20.

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.

Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B.

Nature. 2007 Aug 30;448(7157):1063-7.

PMID:
17728759

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