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Items: 1 to 20 of 55


In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.

Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, Reif DM, Rotroff DM, Shah I, Richard AM, Dix DJ.

Environ Health Perspect. 2010 Apr;118(4):485-92. doi: 10.1289/ehp.0901392.


Mechanisms of immune-mediated liver injury.

Adams DH, Ju C, Ramaiah SK, Uetrecht J, Jaeschke H.

Toxicol Sci. 2010 Jun;115(2):307-21. doi: 10.1093/toxsci/kfq009. Epub 2010 Jan 13. Review.


Pharmacogenomic discovery using cell-based models.

Welsh M, Mangravite L, Medina MW, Tantisira K, Zhang W, Huang RS, McLeod H, Dolan ME.

Pharmacol Rev. 2009 Dec;61(4):413-29. doi: 10.1124/pr.109.001461. Review.


An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity.

Liu HH, Lu P, Guo Y, Farrell E, Zhang X, Zheng M, Bosano B, Zhang Z, Allard J, Liao G, Fu S, Chen J, Dolim K, Kuroda A, Usuka J, Cheng J, Tao W, Welch K, Liu Y, Pease J, de Keczer SA, Masjedizadeh M, Hu JS, Weller P, Garrow T, Peltz G.

Genome Res. 2010 Jan;20(1):28-35. doi: 10.1101/gr.097212.109. Epub 2009 Nov 18.


Cell based approaches for evaluation of drug-induced liver injury.

Greer ML, Barber J, Eakins J, Kenna JG.

Toxicology. 2010 Feb 9;268(3):125-31. doi: 10.1016/j.tox.2009.08.007. Epub 2009 Aug 13. Review.


The toxicity data landscape for environmental chemicals.

Judson R, Richard A, Dix DJ, Houck K, Martin M, Kavlock R, Dellarco V, Henry T, Holderman T, Sayre P, Tan S, Carpenter T, Smith E.

Environ Health Perspect. 2009 May;117(5):685-95. doi: 10.1289/ehp.0800168. Epub 2008 Dec 22. Review.


Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.

Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I.

Toxicol Sci. 2009 Jul;110(1):235-43. doi: 10.1093/toxsci/kfp096. Epub 2009 May 6.


Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW.

Genome Res. 2009 Sep;19(9):1507-15. doi: 10.1101/gr.090241.108. Epub 2009 May 5.


Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis.

Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Müller A, Tuschl G, Mueller SO, Dooley S.

Hepatology. 2009 Jun;49(6):2031-43. doi: 10.1002/hep.22880.


Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver.

Holt AP, Haughton EL, Lalor PF, Filer A, Buckley CD, Adams DH.

Gastroenterology. 2009 Feb;136(2):705-14. doi: 10.1053/j.gastro.2008.10.020. Epub 2008 Oct 15.


Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity.

Harrill AH, Rusyn I.

Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1379-89. doi: 10.1517/17425255.4.11.1379 . Review.


Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures.

Goyak KM, Johnson MC, Strom SC, Omiecinski CJ.

Toxicol Appl Pharmacol. 2008 Sep 1;231(2):216-24. doi: 10.1016/j.taap.2008.04.024. Epub 2008 May 10.


Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.

Campion SN, Johnson R, Aleksunes LM, Goedken MJ, van Rooijen N, Scheffer GL, Cherrington NJ, Manautou JE.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G294-304. doi: 10.1152/ajpgi.00541.2007. Epub 2008 Jun 12.


Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.

Friedman SL.

Physiol Rev. 2008 Jan;88(1):125-72. doi: 10.1152/physrev.00013.2007. Review.


Toxicity testing in the 21st century: a vision and a strategy.

Gibb S.

Reprod Toxicol. 2008 Jan;25(1):136-8. Epub 2007 Nov 1. Review.


Microscale culture of human liver cells for drug development.

Khetani SR, Bhatia SN.

Nat Biotechnol. 2008 Jan;26(1):120-6. Epub 2007 Nov 18.


In silico and in vitro pharmacogenetic analysis in mice.

Guo Y, Lu P, Farrell E, Zhang X, Weller P, Monshouwer M, Wang J, Liao G, Zhang Z, Hu S, Allard J, Shafer S, Usuka J, Peltz G.

Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17735-40. Epub 2007 Oct 31.


Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.

Hewitt NJ, Lecluyse EL, Ferguson SS.

Xenobiotica. 2007 Oct-Nov;37(10-11):1196-224. Review.


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