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Items: 1 to 20 of 103


Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel.

Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, Schulten K.

Biophys J. 2010 May 19;98(10):2189-98. doi: 10.1016/j.bpj.2010.02.056.


A gating charge transfer center in voltage sensors.

Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R.

Science. 2010 Apr 2;328(5974):67-73. doi: 10.1126/science.1185954.


The activated state of a sodium channel voltage sensor in a membrane environment.

Chakrapani S, Sompornpisut P, Intharathep P, Roux B, Perozo E.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5435-40. doi: 10.1073/pnas.0914109107. Epub 2010 Mar 5.


Double gaps along Shaker S4 demonstrate omega currents at three different closed states.

Gamal El-Din TM, Heldstab H, Lehmann C, Greeff NG.

Channels (Austin). 2010 Mar-Apr;4(2):93-100. Epub 2010 Mar 17.


Sequential formation of ion pairs during activation of a sodium channel voltage sensor.

DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22498-503. doi: 10.1073/pnas.0912307106. Epub 2009 Dec 10.


Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels.

Lee SY, Banerjee A, MacKinnon R.

PLoS Biol. 2009 Mar 3;7(3):e47. doi: 10.1371/journal.pbio.1000047.


K+-dependent paradoxical membrane depolarization and Na+ overload, major and reversible contributors to weakness by ion channel leaks.

Jurkat-Rott K, Weber MA, Fauler M, Guo XH, Holzherr BD, Paczulla A, Nordsborg N, Joechle W, Lehmann-Horn F.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4036-41. doi: 10.1073/pnas.0811277106. Epub 2009 Feb 18.


Periodic paralysis.

Fontaine B.

Adv Genet. 2008;63:3-23. doi: 10.1016/S0065-2660(08)01001-8. Review.


Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis.

Sokolov S, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19980-5. doi: 10.1073/pnas.0810562105. Epub 2008 Dec 3.


Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation.

DeCaen PG, Yarov-Yarovoy V, Zhao Y, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15142-7. doi: 10.1073/pnas.0806486105. Epub 2008 Sep 22.


Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion.

Broomand A, Elinder F.

Neuron. 2008 Sep 11;59(5):770-7. doi: 10.1016/j.neuron.2008.07.008.


ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

Schmalhofer WA, Calhoun J, Burrows R, Bailey T, Kohler MG, Weinglass AB, Kaczorowski GJ, Garcia ML, Koltzenburg M, Priest BT.

Mol Pharmacol. 2008 Nov;74(5):1476-84. doi: 10.1124/mol.108.047670. Epub 2008 Aug 26.


Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.

Shafrir Y, Durell SR, Guy HR.

Biophys J. 2008 Oct;95(8):3650-62. doi: 10.1529/biophysj.108.135327. Epub 2008 Jul 18.


Models of voltage-dependent conformational changes in NaChBac channels.

Shafrir Y, Durell SR, Guy HR.

Biophys J. 2008 Oct;95(8):3663-76. doi: 10.1529/biophysj.108.135335. Epub 2008 Jul 18.


Slow inactivation: slow but not dull.

Ruff RL.

Neurology. 2008 Mar 4;70(10):746-7. doi: 10.1212/01.wnl.0000304253.88642.8d. No abstract available.


Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.

Sokolov S, Kraus RL, Scheuer T, Catterall WA.

Mol Pharmacol. 2008 Mar;73(3):1020-8. Epub 2007 Dec 21.


Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.

Long SB, Tao X, Campbell EB, MacKinnon R.

Nature. 2007 Nov 15;450(7168):376-82.


From genes to pain: Na v 1.7 and human pain disorders.

Dib-Hajj SD, Cummins TR, Black JA, Waxman SG.

Trends Neurosci. 2007 Nov;30(11):555-63. Epub 2007 Oct 22. Review.


Tarantula toxins interact with voltage sensors within lipid membranes.

Milescu M, Vobecky J, Roh SH, Kim SH, Jung HJ, Kim JI, Swartz KJ.

J Gen Physiol. 2007 Nov;130(5):497-511. Epub 2007 Oct 15.

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