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Items: 1 to 20 of 278

1.

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain.

Chiu-Ugalde J, Theilig F, Behrends T, Drebes J, Sieland C, Subbarayal P, Köhrle J, Hammes A, Schomburg L, Schweizer U.

Biochem J. 2010 Oct 1;431(1):103-11. doi: 10.1042/BJ20100779.

PMID:
20653565
2.

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.

Chen Y, Durakoglugil MS, Xian X, Herz J.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):12011-6. doi: 10.1073/pnas.0914984107. Epub 2010 Jun 14.

3.

Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.

Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J.

PLoS One. 2010 Apr 29;5(4):e10418. doi: 10.1371/journal.pone.0010418.

4.

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J, Adams DJ.

PLoS One. 2010 Apr 7;5(4):e9960. doi: 10.1371/journal.pone.0009960.

5.

LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.

Li Y, Pawlik B, Elcioglu N, Aglan M, Kayserili H, Yigit G, Percin F, Goodman F, Nürnberg G, Cenani A, Urquhart J, Chung BD, Ismail S, Amr K, Aslanger AD, Becker C, Netzer C, Scambler P, Eyaid W, Hamamy H, Clayton-Smith J, Hennekam R, Nürnberg P, Herz J, Temtamy SA, Wollnik B.

Am J Hum Genet. 2010 May 14;86(5):696-706. doi: 10.1016/j.ajhg.2010.03.004. Epub 2010 Apr 8.

6.

Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway.

Muratoglu SC, Mikhailenko I, Newton C, Migliorini M, Strickland DK.

J Biol Chem. 2010 May 7;285(19):14308-17. doi: 10.1074/jbc.M109.046672. Epub 2010 Mar 10.

7.

Reelin signaling antagonizes beta-amyloid at the synapse.

Durakoglugil MS, Chen Y, White CL, Kavalali ET, Herz J.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15938-43. doi: 10.1073/pnas.0908176106. Epub 2009 Sep 2.

8.

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.

Zhou L, Takayama Y, Boucher P, Tallquist MD, Herz J.

PLoS One. 2009 Sep 9;4(9):e6922. doi: 10.1371/journal.pone.0006922.

9.

Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.

Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL.

Sci Signal. 2009 Apr 28;2(68):ra18. doi: 10.1126/scisignal.2000188.

10.

LRP1 shedding in human brain: roles of ADAM10 and ADAM17.

Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G.

Mol Neurodegener. 2009 Apr 16;4:17. doi: 10.1186/1750-1326-4-17.

11.

Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid.

Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland SD, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM.

Arch Neurol. 2009 Apr;66(4):448-57. doi: 10.1001/archneurol.2009.22.

12.

BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms.

Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Tołoczko-Grabarek A, Gilbert M, Edler L, Zapatka M, Eils R, Lubiński J, Scott RJ, Hamann U.

Breast Cancer Res Treat. 2010 Jan;119(1):201-11. doi: 10.1007/s10549-009-0390-5. Epub 2009 Apr 10.

PMID:
19360465
13.

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.

Deane R, Bell RD, Sagare A, Zlokovic BV.

CNS Neurol Disord Drug Targets. 2009 Mar;8(1):16-30. Review.

14.

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.

Song H, Li Y, Lee J, Schwartz AL, Bu G.

Cancer Res. 2009 Feb 1;69(3):879-86. doi: 10.1158/0008-5472.CAN-08-3379. Epub 2009 Jan 27.

15.

Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3.

Chai X, Förster E, Zhao S, Bock HH, Frotscher M.

J Neurosci. 2009 Jan 7;29(1):288-99. doi: 10.1523/JNEUROSCI.2934-08.2009.

16.

Lrp4 modulates extracellular integration of cell signaling pathways in development.

Ohazama A, Johnson EB, Ota MS, Choi HY, Porntaveetus T, Oommen S, Itoh N, Eto K, Gritli-Linde A, Herz J, Sharpe PT.

PLoS One. 2008;3(12):e4092. doi: 10.1371/journal.pone.0004092. Epub 2008 Dec 31. Erratum in: PLoS ONE. 2009;4(1). doi: 10.1371/annotation/f19bff3b-227a-4159-b166-7dc3c19bec43. Choi, Hong J [corrected to Choi, Hong Y].

17.

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease.

Marzolo MP, Bu G.

Semin Cell Dev Biol. 2009 Apr;20(2):191-200. doi: 10.1016/j.semcdb.2008.10.005. Epub 2008 Oct 17. Review.

18.

Gamma-secretase limits the inflammatory response through the processing of LRP1.

Zurhove K, Nakajima C, Herz J, Bock HH, May P.

Sci Signal. 2008 Nov 25;1(47):ra15. doi: 10.1126/scisignal.1164263.

19.

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV.

J Clin Invest. 2008 Dec;118(12):4002-13. doi: 10.1172/JCI36663. Epub 2008 Nov 13.

20.

Structure and function of gamma-secretase.

Tolia A, De Strooper B.

Semin Cell Dev Biol. 2009 Apr;20(2):211-8. doi: 10.1016/j.semcdb.2008.10.007. Epub 2008 Nov 1. Review.

PMID:
19007897

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