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Items: 20

1.

Allosteric inhibition of human porphobilinogen synthase.

Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK.

J Biol Chem. 2009 Dec 18;284(51):35807-17. doi: 10.1074/jbc.M109.026294.

2.

Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation.

Kokona B, Rigotti DJ, Wasson AS, Lawrence SH, Jaffe EK, Fairman R.

Biochemistry. 2008 Oct 7;47(40):10649-56. doi: 10.1021/bi801128d. Epub 2008 Sep 17.

3.

Shape shifting leads to small-molecule allosteric drug discovery.

Lawrence SH, Ramirez UD, Tang L, Fazliyez F, Kundrat L, Markham GD, Jaffe EK.

Chem Biol. 2008 Jun;15(6):586-96. doi: 10.1016/j.chembiol.2008.04.012.

4.

Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase.

Selwood T, Tang L, Lawrence SH, Anokhina Y, Jaffe EK.

Biochemistry. 2008 Mar 11;47(10):3245-57. doi: 10.1021/bi702113z. Epub 2008 Feb 14.

PMID:
18271513
5.

ALAD porphyria is a conformational disease.

Jaffe EK, Stith L.

Am J Hum Genet. 2007 Feb;80(2):329-37. Epub 2006 Dec 21.

7.

Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins).

Tang L, Breinig S, Stith L, Mischel A, Tannir J, Kokona B, Fairman R, Jaffe EK.

J Biol Chem. 2006 Mar 10;281(10):6682-90. Epub 2005 Dec 23.

8.

Morpheeins--a new structural paradigm for allosteric regulation.

Jaffe EK.

Trends Biochem Sci. 2005 Sep;30(9):490-7. Review.

PMID:
16023348
9.

Substrate-induced interconversion of protein quaternary structure isoforms.

Tang L, Stith L, Jaffe EK.

J Biol Chem. 2005 Apr 22;280(16):15786-93. Epub 2005 Feb 14.

10.

Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces.

Li Y, Huang Y, Swaminathan CP, Smith-Gill SJ, Mariuzza RA.

Structure. 2005 Feb;13(2):297-307.

11.

The porphobilinogen synthase catalyzed reaction mechanism.

Jaffe EK.

Bioorg Chem. 2004 Oct;32(5):316-25. Review.

PMID:
15381398
12.

Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening.

Halgren TA, Murphy RB, Friesner RA, Beard HS, Frye LL, Pollard WT, Banks JL.

J Med Chem. 2004 Mar 25;47(7):1750-9.

PMID:
15027866
13.

Allosteric proteins and cellular control systems.

MONOD J, CHANGEUX JP, JACOB F.

J Mol Biol. 1963 Apr;6:306-29. No abstract available.

PMID:
13936070
14.

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK.

Nat Struct Biol. 2003 Sep;10(9):757-63. Epub 2003 Aug 3.

PMID:
12897770
15.

Binding of small molecules to an adaptive protein-protein interface.

Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. Epub 2003 Feb 11.

17.

Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism.

Frère F, Schubert WD, Stauffer F, Frankenberg N, Neier R, Jahn D, Heinz DW.

J Mol Biol. 2002 Jul 5;320(2):237-47.

PMID:
12079382
18.

Determinants of allosteric activation of yeast pyruvate kinase and identification of novel effectors using computational screening.

Bond CJ, Jurica MS, Mesecar A, Stoddard BL.

Biochemistry. 2000 Dec 19;39(50):15333-43.

PMID:
11112519
19.

The Protein Data Bank.

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE.

Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

20.

X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.

Erskine PT, Senior N, Awan S, Lambert R, Lewis G, Tickle IJ, Sarwar M, Spencer P, Thomas P, Warren MJ, Shoolingin-Jordan PM, Wood SP, Cooper JB.

Nat Struct Biol. 1997 Dec;4(12):1025-31.

PMID:
9406553

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