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Items: 1 to 20 of 60

1.

Regulation of amyloid precursor protein processing by the Beclin 1 complex.

Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T.

PLoS One. 2010 Jun 15;5(6):e11102. doi: 10.1371/journal.pone.0011102.

2.

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA.

Cell. 2010 Jun 25;141(7):1146-58. doi: 10.1016/j.cell.2010.05.008. Epub 2010 Jun 10.

3.

An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH.

Science. 2010 Jul 9;329(5988):229-32. doi: 10.1126/science.1190354. Epub 2010 Jun 3.

4.

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

Hawley SA, Ross FA, Chevtzoff C, Green KA, Evans A, Fogarty S, Towler MC, Brown LJ, Ogunbayo OA, Evans AM, Hardie DG.

Cell Metab. 2010 Jun 9;11(6):554-65. doi: 10.1016/j.cmet.2010.04.001.

5.

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.

Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S, de Vries R, Arias E, Harris S, Sulzer D, Cuervo AM.

Nat Neurosci. 2010 May;13(5):567-76. doi: 10.1038/nn.2528. Epub 2010 Apr 11.

6.

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.

PLoS One. 2010 Apr 1;5(4):e9979. doi: 10.1371/journal.pone.0009979. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/05c1b976-7eab-4154-808d-0526e604b8eb.

7.

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Caccamo A, Majumder S, Richardson A, Strong R, Oddo S.

J Biol Chem. 2010 Apr 23;285(17):13107-20. doi: 10.1074/jbc.M110.100420. Epub 2010 Feb 23.

8.

Turning enzymes ON with small molecules.

Zorn JA, Wells JA.

Nat Chem Biol. 2010 Mar;6(3):179-188.

PMID:
20154666
9.

Physiological significance of selective degradation of p62 by autophagy.

Komatsu M, Ichimura Y.

FEBS Lett. 2010 Apr 2;584(7):1374-8. doi: 10.1016/j.febslet.2010.02.017. Epub 2010 Feb 12. Review.

10.

Alzheimer's disease.

Querfurth HW, LaFerla FM.

N Engl J Med. 2010 Jan 28;362(4):329-44. doi: 10.1056/NEJMra0909142. Review. No abstract available. Erratum in: N Engl J Med. 2011 Feb 10;364(6):588.

PMID:
20107219
11.

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation.

Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, Auberger P.

Cancer Res. 2010 Feb 1;70(3):1042-52. doi: 10.1158/0008-5472.CAN-09-3537. Epub 2010 Jan 26.

12.

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P.

J Biol Chem. 2010 Mar 19;285(12):9100-13. doi: 10.1074/jbc.M109.060061. Epub 2010 Jan 14.

13.

Functional consequences of mTOR inhibition.

Sudarsanam S, Johnson DE.

Curr Opin Drug Discov Devel. 2010 Jan;13(1):31-40. Review.

PMID:
20047144
14.

Effects of AMP-activated protein kinase in cerebral ischemia.

Li J, McCullough LD.

J Cereb Blood Flow Metab. 2010 Mar;30(3):480-92. doi: 10.1038/jcbfm.2009.255. Epub 2009 Dec 16. Review.

15.

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG.

Biochem J. 2010 Jan 27;426(1):109-18. doi: 10.1042/BJ20091372.

16.

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.

Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH.

Diabetes. 2010 Mar;59(3):554-63. doi: 10.2337/db09-0482. Epub 2009 Nov 23.

17.

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.

18.

mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.

Chan EY.

Sci Signal. 2009 Aug 18;2(84):pe51. doi: 10.1126/scisignal.284pe51.

PMID:
19690328
19.

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy.

Poels J, Spasić MR, Callaerts P, Norga KK.

Bioessays. 2009 Sep;31(9):944-52. doi: 10.1002/bies.200900003. Review.

PMID:
19644919
20.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA.

Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.

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