Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 63


c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.

Thien CB, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, Langdon WY.

J Biol Chem. 2010 Apr 2;285(14):10969-81. doi: 10.1074/jbc.M109.094920. Epub 2010 Feb 4.


Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.

Kim JH, Kim K, Jin HM, Song I, Youn BU, Lee SH, Choi Y, Kim N.

J Biol Chem. 2010 Feb 19;285(8):5224-31. doi: 10.1074/jbc.M109.042812. Epub 2009 Dec 26.


c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.

Purev E, Neff L, Horne WC, Baron R.

Mol Biol Cell. 2009 Sep;20(18):4021-30. doi: 10.1091/mbc.E09-03-0248. Epub 2009 Jul 29.


Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

Nakajima A, Sanjay A, Chiusaroli R, Adapala NS, Neff L, Itzsteink C, Horne WC, Baron R.

J Bone Miner Res. 2009 Jul;24(7):1162-72. doi: 10.1359/jbmr.090205.


The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.

Munugalavadla V, Vemula S, Sims EC, Krishnan S, Chen S, Yan J, Li H, Niziolek PJ, Takemoto C, Robling AG, Yang FC, Kapur R.

Mol Cell Biol. 2008 Dec;28(23):7182-98. doi: 10.1128/MCB.00920-08. Epub 2008 Sep 22.


Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia.

Bozec A, Bakiri L, Hoebertz A, Eferl R, Schilling AF, Komnenovic V, Scheuch H, Priemel M, Stewart CL, Amling M, Wagner EF.

Nature. 2008 Jul 10;454(7201):221-5. doi: 10.1038/nature07019. Epub 2008 Jun 11.


Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation.

Yang M, Birnbaum MJ, MacKay CA, Mason-Savas A, Thompson B, Odgren PR.

J Cell Physiol. 2008 May;215(2):497-505.


Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.

Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J.

J Cell Biol. 2007 Sep 10;178(6):1053-64.


Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action.

Molero JC, Turner N, Thien CB, Langdon WY, James DE, Cooney GJ.

Diabetes. 2006 Dec;55(12):3411-7.


v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation.

Lee SH, Rho J, Jeong D, Sul JY, Kim T, Kim N, Kang JS, Miyamoto T, Suda T, Lee SK, Pignolo RJ, Koczon-Jaremko B, Lorenzo J, Choi Y.

Nat Med. 2006 Dec;12(12):1403-9. Epub 2006 Nov 26.


Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts.

Luxenburg C, Parsons JT, Addadi L, Geiger B.

J Cell Sci. 2006 Dec 1;119(Pt 23):4878-88. Epub 2006 Nov 14.


The molecular understanding of osteoclast differentiation.

Asagiri M, Takayanagi H.

Bone. 2007 Feb;40(2):251-64. Epub 2006 Nov 13. Review.


Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.

Sanjay A, Miyazaki T, Itzstein C, Purev E, Horne WC, Baron R.

FEBS J. 2006 Dec;273(23):5442-56. Epub 2006 Nov 9.


PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation.

Patra AK, Drewes T, Engelmann S, Chuvpilo S, Kishi H, H√ľnig T, Serfling E, Bommhardt UH.

J Immunol. 2006 Oct 1;177(7):4567-76.


The Cbl family proteins: ring leaders in regulation of cell signaling.

Swaminathan G, Tsygankov AY.

J Cell Physiol. 2006 Oct;209(1):21-43. Review.


The molecular dynamics of osteoclast adhesions.

Luxenburg C, Addadi L, Geiger B.

Eur J Cell Biol. 2006 Apr;85(3-4):203-11. Epub 2005 Dec 19.


The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function.

Horne WC, Sanjay A, Bruzzaniti A, Baron R.

Immunol Rev. 2005 Dec;208:106-25. Review.


Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.

Humphrey MB, Lanier LL, Nakamura MC.

Immunol Rev. 2005 Dec;208:50-65. Review.


Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, Langdon WY.

EMBO J. 2005 Nov 2;24(21):3807-19. Epub 2005 Oct 6.

Supplemental Content

Support Center