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DNA damage response and tumorigenesis in Mcm2-deficient mice.

Kunnev D, Rusiniak ME, Kudla A, Freeland A, Cady GK, Pruitt SC.

Oncogene. 2010 Jun 24;29(25):3630-8. doi: 10.1038/onc.2010.125. Epub 2010 May 3.


Aneuploidy and improved growth are coincident but not causal in a yeast cancer model.

Li XC, Schimenti JC, Tye BK.

PLoS Biol. 2009 Jul;7(7):e1000161. doi: 10.1371/journal.pbio.1000161. Epub 2009 Jul 28.


The Mcm2-7 complex has in vitro helicase activity.

Bochman ML, Schwacha A.

Mol Cell. 2008 Jul 25;31(2):287-93. doi: 10.1016/j.molcel.2008.05.020.


Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

Ibarra A, Schwob E, Méndez J.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8956-61. doi: 10.1073/pnas.0803978105. Epub 2008 Jun 25.


Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex.

Lin DI, Aggarwal P, Diehl JA.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8079-84. doi: 10.1073/pnas.0800077105. Epub 2008 Jun 4.


Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

Brambrink T, Foreman R, Welstead GG, Lengner CJ, Wernig M, Suh H, Jaenisch R.

Cell Stem Cell. 2008 Feb 7;2(2):151-9. doi: 10.1016/j.stem.2008.01.004.


Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells.

Crevel G, Hashimoto R, Vass S, Sherkow J, Yamaguchi M, Heck MM, Cotterill S.

PLoS One. 2007 Sep 5;2(9):e833.


Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.

Pruitt SC, Bailey KJ, Freeland A.

Stem Cells. 2007 Dec;25(12):3121-32. Epub 2007 Aug 23.


Genetic screen for chromosome instability in mice: Mcm4 and breast cancer.

Shima N, Buske TR, Schimenti JC.

Cell Cycle. 2007 May 15;6(10):1135-40. Epub 2007 May 5.


A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.

Shima N, Alcaraz A, Liachko I, Buske TR, Andrews CA, Munroe RJ, Hartford SA, Tye BK, Schimenti JC.

Nat Genet. 2007 Jan;39(1):93-8. Epub 2006 Dec 3.


Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.

Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C, Schurra C, Garre' M, Nuciforo PG, Bensimon A, Maestro R, Pelicci PG, d'Adda di Fagagna F.

Nature. 2006 Nov 30;444(7119):638-42.


Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG.

Nature. 2006 Nov 30;444(7119):633-7.


Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing.

Pan H, Deng Y, Pollard JW.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14021-6. Epub 2006 Sep 11.


Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

Moyer SE, Lewis PW, Botchan MR.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10236-10241. doi: 10.1073/pnas.0602400103. Epub 2006 Jun 23.


Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

Woodward AM, Göhler T, Luciani MG, Oehlmann M, Ge X, Gartner A, Jackson DA, Blow JJ.

J Cell Biol. 2006 Jun 5;173(5):673-83.


The MCM complex: its role in DNA replication and implications for cancer therapy.

Lei M.

Curr Cancer Drug Targets. 2005 Aug;5(5):365-80. Review.


CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication.

Liku ME, Nguyen VQ, Rosales AW, Irie K, Li JJ.

Mol Biol Cell. 2005 Oct;16(10):5026-39. Epub 2005 Aug 10.


Preventing re-replication of chromosomal DNA.

Blow JJ, Dutta A.

Nat Rev Mol Cell Biol. 2005 Jun;6(6):476-86. Review.


Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD.

Nature. 2005 Apr 14;434(7035):907-13.


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